Genetic testing prior authorization and code list
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This document lists services requiring prior authorization for Federal Employees Health Benefits (FEHB) members and includes an extensive list of genetic testing CPT/HCPCS/PLA codes; it applies to providers serving FEHB (FEP) members. It identifies penalties for failure to obtain required precertification/prior approval for certain programs.
No material clinical or coverage changes in this revision.
Coverage Criteria - Services Requiring Prior Authorization
The policy specifically lists Outpatient residential treatment center care and identifies the associated revenue code range as 086X. Services billed with revenue codes in the 086X range are therefore captured by this policy and subject to the policy’s authorization and coverage requirements.
The policy identifies breast reduction and augmentation procedures not related to treatment of cancer by listing applicable CPT codes, including 15777 and 19316 among others. These procedures are noted separately in the policy and are treated as non–cancer‑related breast reduction/augmentation services for coverage and authorization purposes.
Coding - CPT/HCPCS/Revenue/NDC Groups and Lists
| 0042T | MRI/CT/PET related |
| 0332T | MRI/CT/PET related |
| 0398T | MRI/CT/PET related |
| 0501T | MRI/CT/PET related |
| 086X | Revenue code range for outpatient residential treatment center care for any condition |
| C9161 | High-cost drugs provided in the medical setting (listed examples) |
| C9257 | High-cost drugs provided in the medical setting (listed examples) |
| JO222 | High-cost drugs provided in the medical setting (listed examples) |
| J0223 | High-cost drugs provided in the medical setting (listed examples) |
| J0224 | High-cost drugs provided in the medical setting (listed examples) |
| J0178 | High-cost drugs provided in the medical setting (listed examples) |
| J0179 | High-cost drugs provided in the medical setting (listed examples) |
| J0225 | High-cost drugs provided in the medical setting (listed examples) |
| J0885 | High-cost drugs provided in the medical setting (listed examples) |
| J1300 | High-cost drugs provided in the medical setting (listed examples) |
| E0265 | Specialty durable medical equipment (rental or purchase) |
| E0266 | Specialty durable medical equipment (rental or purchase) |
| E0270 | Specialty durable medical equipment (rental or purchase) |
| K0010 | Specialty durable medical equipment (rental or purchase) |
| K0011 | Specialty durable medical equipment (rental or purchase) |
| K0838 | Specialty durable medical equipment (rental or purchase) |
| K0899 | Specialty durable medical equipment (rental or purchase) |
| 38240 | Blood or marrow stem cell transplants |
| 38241 | Blood or marrow stem cell transplants |
| S2142 | Blood or marrow stem cell transplants |
| S2150 | Blood or marrow stem cell transplants |
| 38205 | Donor code (not subject to penalty when prior approval not obtained) |
| 38206 | Donor code (not subject to penalty when prior approval not obtained) |
| 38207 | Donor code (not subject to penalty when prior approval not obtained) |
| 38230 | Donor code (not subject to penalty when prior approval not obtained) |
| 38232 | Donor code (not subject to penalty when prior approval not obtained) |
| S2140 | Donor code (not subject to penalty when prior approval not obtained) |
Provider Actions - Prior Authorization, Documentation, and Penalties
Genetic testing prior authorization required
Genetic testing codes listed require prior authorization before services are rendered. Submit prior authorization for any of the listed CPT/HCPCS/Proprietary codes to avoid denial or penalty.
- Prior authorization required for all listed genetic testing codes.
- Include clinical documentation supporting medical necessity with the request.
Prior approval required for selected therapies and gender-affirming surgery
Prior approval is required for selected high-cost therapies and for gender-affirming surgeries. Requests must list all anticipated procedures and estimated dates when applicable.
- Proton Beam Therapy: prior approval required except for members aged 21 and younger or for specified neoplasm indications.
- Stereotactic Radiosurgery / Stereotactic Body Radiation Therapy: prior approval required except for specified indications (brain, eye choroid/ciliary body, certain benign cranial neoplasms, functional/neuralgic/AVM conditions).
- Gender-affirming Surgery: prior approval request must include all planned surgical procedures and estimated procedure dates; examples of relevant codes include 11920–11922, 17380, 19303, 19318, 19350, 53430, 54400–54405, 54660, 55175–55180, 55899, 55970–55980, 56625, 57110, 58150–58573, 58661, 58720, 58999, C1813, C2622.
Penalties for failure to obtain required precertification/prior approval
Failure to obtain required precertification or prior approval will result in provider financial penalties as specified by the plan.
- Inpatient admissions: obtain admission precertification and any required continued-stay reviews; maternity and urgent/emergent admission rules apply as noted in policy.
- Prior approval is required for many services (see therapy, transplant, genetic testing, and high-cost drug sections); lack of prior approval may trigger the $100 penalty for other services.
Transplant prior authorization and designated center requirements
Prior approval (preauthorization) and documentation requirements for transplant services.
- Schedule transplant only after obtaining prior approval; verify whether the transplant must be performed at a designated Blue Distinction Center.
- Include supporting documentation with the prior approval request per transplant program requirements.
- Donor codes listed are exempt from penalty if prior approval is not obtained, but transplant program rules and coverage limits still apply.
Background and Scope
This portion of the policy identifies specific services that are subject to prior authorization and medical necessity review. Examples called out include Outpatient residential treatment center care (revenue code range 086X) and non‑cancer‑related breast reduction/augmentation procedures (listed CPT codes such as 15777, 19316, etc.). Providers should recognize that services billed under these codes or revenue ranges are governed by the policy’s prior authorization and coverage rules and must follow the documented authorization procedures.
Definitions and Precertification Rules
OpenPayer is powered by Trek Health's payer performance platform. Trek continuously ingests, validates, and normalizes Transparency in Coverage data alongside payer policies and other commercial payer data to create a structured payer intelligence foundation. OpenPayer uses this foundation to deliver personalized search results, dynamically generated policy pages, and tailored policy monitoring based on each user's payers, specialties, billing codes, and areas of interest. The same intelligence powers broader payer performance workflows, including reimbursement benchmarking, contract evaluation, payer negotiations, and financial decision-making.