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CPT 58322: Intrauterine Insemination (Insertion of Prepared Sperm)

CPT code 58322 identifies intrauterine insemination (IUI), a reproductive medicine procedure in which prepared live sperm are placed directly into the uterus via the cervical canal. This code captures a commonly used fertility intervention that affects coverage, access, and billing practices nationwide because of its frequency in outpatient reproductive care and its variable coverage across payers. Major payers included in national coverage discussions are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise briefing on the clinical context for IUI, typical sites of service, and why correct coding matters for claims processing and patient access. The publication summarizes payer coverage patterns and benchmarks where available, highlights common billing considerations and allowed modifiers, and outlines policy and reimbursement topics that influence utilization. Data not available in the input will be noted where relevant. This resource is intended to inform coding professionals, practice managers, and policy analysts about the role of CPT code 58322 in reproductive health billing and policy.

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Billing Code Overview

CPT code 58322 describes a procedure in which the provider inserts prepared live sperm into the uterus through the cervical canal. This service is an intrauterine insemination (IUI) procedure.

Service type: Reproductive medicine procedure (intrauterine insemination)
Typical site of service: Ambulatory clinic or outpatient reproductive endocrinology/infertility center where minor invasive procedures are performed

Find policies, billing codes, payers, states, and providers

CPT 58322: Intrauterine Insemination (Insertion of Prepared Sperm)

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Get alerted when payer policies referencing 58322 are released or updated.

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Billing Code Overview

CPT code 58322 describes a procedure in which the provider inserts prepared live sperm into the uterus through the cervical canal. This service is an intrauterine insemination (IUI) procedure.

Service type: Reproductive medicine procedure (intrauterine insemination)
Typical site of service: Ambulatory clinic or outpatient reproductive endocrinology/infertility center where minor invasive procedures are performed

Clinical & Coding Specifications

Clinical Context

A 34-year-old woman with a 2-year history of infertility presents to a reproductive endocrinology clinic for intrauterine insemination (IUI). She has regular menstrual cycles and normal ovulatory function after ovulation induction with clomiphene citrate. Her partner provided a semen sample that was processed by the andrology laboratory to isolate motile, prepared sperm. On the day of ovulation, the patient presents to the outpatient clinic early in the morning. A transvaginal ultrasound confirms a dominant follicle; the provider performs the procedure by inserting prepared live sperm through the cervical canal into the uterine cavity using a sterile catheter. The procedure is performed in an ambulatory clinic procedure room; the patient is monitored briefly afterward for cramping or vasovagal symptoms and discharged the same day with routine post-procedure guidance. Typical payors covering this service include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, BUCA, and Medicare depending on plan coverage and state mandates.

Coding Specifications

Modifier	Description	When to Use
`25`	Significant, separately identifiable evaluation and management (E/M) service by the same physician on the day of a procedure	Use when a separate E/M visit is documented on the same day as the IUI for issues beyond routine procedural consent and counseling.
`52`	Reduced services	Use if the IUI procedure is partially reduced or not completed as originally planned.
`53`	Discontinued procedure	Use when the IUI is started but terminated due to a circumstance that jeopardizes patient safety before completion.
`59`	Distinct procedural service	Use to indicate a distinct procedure performed on the same day that is not normally reported together with IUI.
`76`	Repeat procedure by same physician (note: `76` not in provided list; use `77` alternative not provided)	Data not available in the input.
`62`	Two surgeons	Use when two qualified physicians perform parts of the procedure and both are reporting.
`52`	Reduced services	Use when the insemination is modified (e.g., fewer catheter passes) — (duplicate entry avoided in billing; document reason).
`79`	Unrelated procedure or service by the same physician during the postoperative period	Use when an unrelated procedure is performed the same day during global period.
`22`	Increased procedural services	Use when the IUI requires significantly greater work or time than typical, documented with rationale.
`59`	Distinct procedural service	Use to separate another procedure performed the same day that is not bundled with IUI — ensure documentation supports distinct service.

Taxonomy Code	Specialty	Notes
`207V00000X`	Reproductive Endocrinology and Infertility (REI)	Specialists who most commonly perform IUI.
`207L00000X`	Obstetrics & Gynecology	Gynecologists in fertility clinics or private practice perform IUI.
`163W00000X`	Clinical Laboratory	Andrology/lab personnel process and prepare sperm sample; usually billed separately by the lab.
`208D00000X`	Family Medicine	In some settings family physicians with fertility training may perform IUI.
`208000000X`	Internal Medicine	Rarely performs IUI; included for completeness in multi-specialty practices.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`N97.9`	Female infertility, unspecified	Common indication for IUI when infertility is primary clinical concern.
`N97.1`	Female infertility associated with anovulation	IUI may be used in patients with ovulatory dysfunction often combined with ovulation induction.
`N46`	Male infertility	Male factor may indicate need for semen preparation and IUI when sperm parameters are adequate for insemination.
`N97.0`	Female infertility due to tubal factor	IUI may be considered in select cases when tubal issues are partial and other factors favorable.
`E28.2`	Polycystic ovarian syndrome (PCOS)	PCOS-related anovulation is a frequent indication for ovulation induction followed by IUI.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`58322`	Insertion of prepared live sperm into the uterus through the cervical canal (intrauterine insemination)	Primary procedure code describing the IUI service.
`89250`	Semen preparation techniques including prewash and postwash total motile sperm count	Performed by the andrology lab prior to `58322` to prepare sperm for insemination and document inseminant quality.
`76830`	Ultrasound, transvaginal or perineal (non-obstetric), real-time with image documentation	Often performed prior to `58322` to monitor follicular development and time insemination.
`99212`	Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexity	Common E/M code used for pre-procedure counseling or same-day visit when minor decision-making is documented (use `25` modifier if billed same day).
`99000`	Handling and/or conveyance of specimen for transfer from the physician to a laboratory	Used when a semen specimen is transferred to the lab for preparation prior to `58322`.

CPT 58300: Contraceptive Intrauterine Device (IUD) Placement

CPT-58301-IUD-REMOVAL

CPT 58301: Removal of Contraceptive Intrauterine Device (IUD)

CPT-58321-INTRACERVICAL-INSEMINATION-PREPARED-SPERM

CPT 58321: Intra-cervical Insemination with Prepared Sperm

CPT-58323-SPERM-PREPARATION-FOR-INSEMINATION

CPT 58323: Sperm Preparation for Insemination

CPT-58340-UTERINE-FALLOPIAN-TUBE-CONTRAST-OR-SALINE-CATHETERIZATION

CPT 58340: Uterine and Fallopian Tube Catheterization with Saline or Contrast

CPT-58345-TRANSCERVICAL-TUBAL-CATHETERIZATION-INFERTILITY

CPT 58345: Transcervical Tubal Catheterization for Infertility

CPT-58346-HEYMAN-CAPSULE-UTERINE-BRACHYTHERAPY-INSERTION

CPT 58346: Heyman Capsule Insertion for Uterine Brachytherapy

CPT-58350-CHROMOTUBATION-FALLOPIAN-TUBE-PATENCY-ASSESSMENT

CPT 58350: Chromotubation for Fallopian Tube Patency Assessment

CPT-58353-THERMAL-ENDOMETRIAL-ABLATION-WITHOUT-HYSTEROSCOPY

CPT 58353: Thermal Endometrial Ablation Without Hysteroscopy

CPT-58356-ENDOMETRIAL-CRYOABLATION-UTERINE-BLEEDING

CPT 58356: Endometrial Cryoablation for Abnormal Uterine Bleeding

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`25`	Significant, separately identifiable evaluation and management (E/M) service by the same physician on the day of a procedure	Use when a separate E/M visit is documented on the same day as the IUI for issues beyond routine procedural consent and counseling.
`52`	Reduced services	Use if the IUI procedure is partially reduced or not completed as originally planned.
`53`	Discontinued procedure	Use when the IUI is started but terminated due to a circumstance that jeopardizes patient safety before completion.
`59`	Distinct procedural service	Use to indicate a distinct procedure performed on the same day that is not normally reported together with IUI.
`76`	Repeat procedure by same physician (note: `76` not in provided list; use `77` alternative not provided)	Data not available in the input.
`62`	Two surgeons	Use when two qualified physicians perform parts of the procedure and both are reporting.
`52`	Reduced services	Use when the insemination is modified (e.g., fewer catheter passes) — (duplicate entry avoided in billing; document reason).
`79`	Unrelated procedure or service by the same physician during the postoperative period	Use when an unrelated procedure is performed the same day during global period.
`22`	Increased procedural services	Use when the IUI requires significantly greater work or time than typical, documented with rationale.
`59`	Distinct procedural service	Use to separate another procedure performed the same day that is not bundled with IUI — ensure documentation supports distinct service.

Taxonomy Code	Specialty	Notes
`207V00000X`	Reproductive Endocrinology and Infertility (REI)	Specialists who most commonly perform IUI.
`207L00000X`	Obstetrics & Gynecology	Gynecologists in fertility clinics or private practice perform IUI.
`163W00000X`	Clinical Laboratory	Andrology/lab personnel process and prepare sperm sample; usually billed separately by the lab.
`208D00000X`	Family Medicine	In some settings family physicians with fertility training may perform IUI.
`208000000X`	Internal Medicine	Rarely performs IUI; included for completeness in multi-specialty practices.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`N97.9`	Female infertility, unspecified	Common indication for IUI when infertility is primary clinical concern.
`N97.1`	Female infertility associated with anovulation	IUI may be used in patients with ovulatory dysfunction often combined with ovulation induction.
`N46`	Male infertility	Male factor may indicate need for semen preparation and IUI when sperm parameters are adequate for insemination.
`N97.0`	Female infertility due to tubal factor	IUI may be considered in select cases when tubal issues are partial and other factors favorable.
`E28.2`	Polycystic ovarian syndrome (PCOS)	PCOS-related anovulation is a frequent indication for ovulation induction followed by IUI.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`58322`	Insertion of prepared live sperm into the uterus through the cervical canal (intrauterine insemination)	Primary procedure code describing the IUI service.
`89250`	Semen preparation techniques including prewash and postwash total motile sperm count	Performed by the andrology lab prior to `58322` to prepare sperm for insemination and document inseminant quality.
`76830`	Ultrasound, transvaginal or perineal (non-obstetric), real-time with image documentation	Often performed prior to `58322` to monitor follicular development and time insemination.
`99212`	Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexity	Common E/M code used for pre-procedure counseling or same-day visit when minor decision-making is documented (use `25` modifier if billed same day).
`99000`	Handling and/or conveyance of specimen for transfer from the physician to a laboratory	Used when a semen specimen is transferred to the lab for preparation prior to `58322`.

CPT 58300: Contraceptive Intrauterine Device (IUD) Placement

CPT-58301-IUD-REMOVAL

CPT 58301: Removal of Contraceptive Intrauterine Device (IUD)

CPT-58321-INTRACERVICAL-INSEMINATION-PREPARED-SPERM

CPT 58321: Intra-cervical Insemination with Prepared Sperm

CPT-58323-SPERM-PREPARATION-FOR-INSEMINATION

CPT 58323: Sperm Preparation for Insemination

CPT-58340-UTERINE-FALLOPIAN-TUBE-CONTRAST-OR-SALINE-CATHETERIZATION

CPT 58340: Uterine and Fallopian Tube Catheterization with Saline or Contrast

CPT-58345-TRANSCERVICAL-TUBAL-CATHETERIZATION-INFERTILITY

CPT 58345: Transcervical Tubal Catheterization for Infertility

CPT-58346-HEYMAN-CAPSULE-UTERINE-BRACHYTHERAPY-INSERTION

CPT 58346: Heyman Capsule Insertion for Uterine Brachytherapy

CPT-58350-CHROMOTUBATION-FALLOPIAN-TUBE-PATENCY-ASSESSMENT

CPT 58350: Chromotubation for Fallopian Tube Patency Assessment

CPT-58353-THERMAL-ENDOMETRIAL-ABLATION-WITHOUT-HYSTEROSCOPY

CPT 58353: Thermal Endometrial Ablation Without Hysteroscopy

CPT-58356-ENDOMETRIAL-CRYOABLATION-UTERINE-BLEEDING

CPT 58356: Endometrial Cryoablation for Abnormal Uterine Bleeding

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 58322: Intrauterine Insemination (Insertion of Prepared Sperm)

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Billing Code Overview

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CPT 58322: Intrauterine Insemination (Insertion of Prepared Sperm)

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

CPT 58322: Intrauterine Insemination (Insertion of Prepared Sperm)

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Billing Code Overview

CPT 58322: Intrauterine Insemination (Insertion of Prepared Sperm)

Sign up for cpt 58322 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 58322 represent and where is this service usually performed?

When should modifier 25 be applied to an IUI claim?

Are related lab or ultrasound services billed together with 58322 or separately?

Which payors typically cover CPT 58322 and does coverage vary?

What ICD-10 diagnosis codes are commonly used with CPT 58322?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 58322 represent and where is this service usually performed?

When should modifier 25 be applied to an IUI claim?

Are related lab or ultrasound services billed together with 58322 or separately?

Which payors typically cover CPT 58322 and does coverage vary?

What ICD-10 diagnosis codes are commonly used with CPT 58322?

References