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    v1.0.30
    OpenPayerBilling CodesReproductive Medicine ProceduresCPT cpt-89346-oocyte-storage-annual
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    CPT 89346: Storage of One or More Oocytes, Per Year

    CPT code 89346 describes laboratory storage of one or more oocytes (egg cells) for a specified time and is reported once per year of storage; this service is a laboratory reproductive cell cryostorage procedure typically classified as an assisted reproductive technology (ART) support service and is commonly performed in specialty fertility clinics or laboratory facilities where long-term tissue and gamete preservation is managed.

    For related coverage guidance, see recent payer policy updates: Prenatal (Fetal) Diagnostic Testing, Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency.

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    Clinical & Coding Specifications

    Clinical Context

    A 33-year-old woman undergoing in vitro fertilization (IVF) elects for elective long-term cryostorage of retrieved oocytes prior to embryo creation. After ovarian stimulation and transvaginal oocyte retrieval performed in an outpatient ambulatory surgery center, the embryology laboratory receives multiple mature oocytes. The lab analyst documents identification, vitrification, and placement of the oocytes into cryogenic storage tanks. The storage service is billed annually for custody and maintenance of the eggs. Typical workflow: oocyte retrieval procedure → laboratory processing (assessment, vitrification) → inventorying and labeling → placement into long-term liquid nitrogen storage → periodic monitoring and annual billing using the storage-per-year code. Typical site of service: hospital-affiliated or freestanding ambulatory surgery center with on-site embryology laboratory or dedicated fertility clinic laboratory. Typical patient scenario: fertility preservation for planned cancer therapy, social/elective fertility preservation, or delayed family building after ovarian stimulation and egg retrieval, requiring annual storage of one or more oocytes billed per year using 89346.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    58970Laparoscopy, surgical; with oophorectomy or oophoropexy (only if applicable)Not typically required for oocyte storage but may relate when surgical ovarian procedures are performed prior to or instead of transvaginal retrieval
    58974Oocyte retrieval, any method (eg, transvaginal aspiration)The procedural step that yields oocytes for subsequent storage billed under 89346 annually
    89258Oocyte identification with or without zona pellucida removal for diagnostic purposesLaboratory processing steps that may precede vitrification and storage
    89250Embryo culture, less than 72 hours (per embryo)Related laboratory services when oocytes are fertilized and embryos cultured rather than stored as oocytes
    89258Semen processing (note: code repeated for related analytic lab services)Ancillary laboratory services commonly performed in ART workflows
    89355Cryopreservation; sperm (procedures for other gametes)Related cryostorage procedures for sperm; analogous processes and billing considerations

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    103K00000X
    207R00000X
    363A00000X
    170100000X
    1744P3200X
    2086S0120X
    261QM0801X
    163WN1003X

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    C56.9Malignant neoplasm of unspecified ovary
    C79.82Secondary malignant neoplasm of genital organs
    D46.9Myelodysplastic syndrome, unspecified
    E28.2Polycystic ovarian syndrome
    E28.8Other ovarian dysfunction
    N80.9Endometriosis, unspecified
    N91.1Secondary amenorrhea
    N91.2Amenorrhea, unspecified
    N92.0Excessive and frequent menstruation with regular cycle
    N92.1Excessive and frequent menstruation with irregular cycle

    Showing 1–10 of 20

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Prenatal (Fetal) Diagnostic TestingBlue Cross Blue Shield - Rhode Island2027-01-01
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Polygenic Risk ScoreBlue Cross Blue Shield - Rhode Island2026-12-01
    Gene Expression Profiling for Cutaneous MelanomaBlue Cross Blue Shield - Rhode Island2026-12-01
    Genetic Testing for Diagnosis and Management of Mental Health ConditionsBlue Cross Blue Shield - Rhode Island2026-11-01
    Molecular Testing in the Management of Pulmonary NodulesBlue Cross Blue Shield - Rhode Island2026-11-01
    Genetic Testing for Hereditary Cancer (for North Carolina Only)Colorado Rocky Mountain Health Plans2026-10-01
    Expanded Molecular Testing of Cancers to Select Targeted TherapiesBlue Cross Blue Shield - North Dakota2026-10-01

    Related Codes

    CPT-89250-SHORT-TERM-OOCYTE-EMBRYO-CULTURE-ART

    CPT 89250: Oocyte or Embryo Culture <4 Days

    CPT-89251-OOCYTE-EMBRYO-SHORT-TERM-COCULTURE-ART

    CPT 89251: Oocyte/Embryo Culture with Coculture (<4 days)

    CPT-89253-ASSISTED-EMBRYO-HATCHING-PARTIAL-ZONA-DISSECTION

    CPT 89253: Assisted Embryo Hatching, Partial Zona Dissection

    CPT-89254-FOLLICULAR-FLUID-OOCYTE-IDENTIFICATION-LAB

    CPT 89254: Oocyte Identification from Follicular Fluid

    CPT-89255-EMBRYO-PREPARATION-FOR-TRANSFER-ART

    CPT 89255: Embryo Preparation for Transfer (ART)

    CPT-89257-SPERM-IDENTIFICATION-FROM-ASPIRATION

    CPT 89257: Identification of Sperm from Non-Seminal Aspirates

    CPT-89258-EMBRYO-CRYOPRESERVATION-IVF

    CPT 89258: Embryo Cryopreservation During IVF Cycle

    CPT-89259-SPERM-CRYOPRESERVATION-AND-PRESERVATION

    CPT 89259: Sperm Cryopreservation, Laboratory Processing

    CPT-89260-LABORATORY-SPERM-PREPARATION-SPERM-WASH-SWIM-UP

    CPT 89260: Sperm Isolation for Sperm Wash and Swim‑Up Preparation

    CPT-89261-SPERM-PREPARATION-AND-SEMEN-ANALYSIS

    CPT 89261: Complex Sperm Preparation and Semen Analysis

    Showing 1–10 of 36

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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