CPT code 38206 denotes the collection of hematopoietic progenitor cells (HPCs) from a patient’s peripheral blood using an apheresis procedure. This autologous HPC collection is a critical preparatory step for hematopoietic stem cell transplantation and cellular therapies. Nationally, the code is used across hospitals, outpatient apheresis units, and specialized infusion centers where trained teams and dedicated apheresis equipment perform the procedure.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical and billing context for CPT code 38206, an overview of common payer coverage patterns, and operational benchmarks relevant to the procedure. The publication summarizes typical sites of service, service components reflected by the code, and common modifiers used with this service where applicable.

This report provides clinicians, practice managers, and revenue cycle professionals with the clinical rationale for the code, payer considerations, and the types of documentation and care settings associated with autologous HPC apheresis. Data gaps in the input are noted where specific payer policy details or associated taxonomies and diagnoses were not provided.