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    OpenPayerBilling CodesIntroduction Procedures on the Corpus UteriCPT cpt-58321-intracervical-insemination-prepared-sperm
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    CPT 58321: Intra-cervical Insemination, Insertion of Prepared Sperm

    Medicare pays $86 on average nationally for this procedure.

    CPT code 58321 describes intra-cervical insemination in which the provider inserts prepared live sperm into the cervical canal; this is an in-office fertility procedure performed as a sperm insemination service, typically delivered in an outpatient clinic or physician’s office setting where reproductive services are provided.

    For related coverage guidance, see recent payer policy updates: Abortion Services, Prolonged Services for Labor Management, Prolonged Services for Labor Management.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old woman with a history of unexplained infertility presents to a reproductive endocrinology clinic after 12 months of unsuccessful conception while attempting timed intercourse. Her partner provides a semen sample that is processed in the laboratory to concentrate motile sperm (wash and preparation). The patient is scheduled for intrauterine insemination via the cervical canal where the prepared live sperm will be placed at or just beyond the cervical os using a catheter. The clinical workflow includes pre-procedure counseling, confirmation of no active infection, ovulation timing (natural cycle or with ovulation induction medications such as clomiphene or letrozole), semen collection and processing in the andrology lab, and the insemination procedure performed in an outpatient clinic exam room or a procedure room. Post-procedure instructions are given and a follow-up pregnancy test is arranged in approximately 2 weeks.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    58321Insertion of prepared live sperm into cervical canal (intrauterine insemination via cervix)Primary procedure: direct placement of prepared sperm into the cervical canal as described.
    51701Insertion of temporary indwelling bladder catheter; simple (e.g., straight Foley)May be performed if urinary catheterization is needed for bladder drainage prior to insemination in specific clinical situations.
    58300Removal of intrauterine devicePerformed if an intrauterine device is present and must be removed prior to insemination.
    89250Embryo transfer, intrauterineDifferent assisted reproductive procedure; used in workflows when IVF/embryo transfer is performed instead of insemination.
    89252Semen analysis, completePerformed before or during treatment cycle to evaluate sperm count, motility, and morphology prior to preparing sample for insemination.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207V00000X
    363L00000X
    367A00000X
    2471B0102X
    261QR0405X
    320800000X
    252Y00000X
    173C00000X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    N46.9Male infertility, unspecified
    N72Inflammatory disease of cervix uteri
    N76.0Acute vaginitis
    N76.1Subacute and chronic vaginitis
    N76.2Acute vulvitis
    N88.0Leukoplakia of cervix uteri
    N88.1Old laceration of cervix uteri
    N91.0Primary amenorrhea
    N91.1Secondary amenorrhea
    N91.2Amenorrhea, unspecified

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Obstetrics/Gynecology1 / 2

    10 rows

    PolicyPayerEffective Date
    Abortion ServicesNew Mexico Health Care Authority2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Obstetrical Home Care ProgramsAmbetter Georgia2026-11-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesBlue Cross Blue Shield - Massachusetts2026-10-01
    Cervical Cancer ScreeningOscar Health2026-10-01
    Prenatal Testing for Fetal AneuploidyOscar Health2026-10-01
    Diagnosis of VaginitisOscar Health2026-10-01

    Related Codes

    CPT-58300-IUD-INSERTION-CONTRACEPTIVE-DEVICE-PLACEMENT

    CPT 58300: Insertion of Contraceptive Intrauterine Device

    CPT-58301-IUD-REMOVAL

    CPT 58301: Removal of Intrauterine Contraceptive Device

    CPT-58322-INTRAUTERINE-INSEMINATION-IUI-INSERTION-OF-PREPARED-SPERM

    CPT 58322: Intrauterine Insemination with Prepared Sperm

    CPT-58323-SPERM-PREPARATION-FOR-INSEMINATION

    CPT 58323: Sperm Preparation for Insemination

    CPT-58340-UTERINE-FALLOPIAN-TUBE-CONTRAST-OR-SALINE-CATHETERIZATION

    CPT 58340: Uterine and Fallopian Tube Catheterization with Contrast

    CPT-58345-TRANSCERVICAL-TUBAL-CATHETERIZATION-INFERTILITY

    CPT 58345: Fallopian Tube Catheterization with Hysterosalpingogram

    CPT-58346-HEYMAN-CAPSULE-UTERINE-BRACHYTHERAPY-INSERTION

    CPT 58346: Insertion of Heyman Capsules for Uterine Brachytherapy

    CPT-58350-CHROMOTUBATION-FALLOPIAN-TUBE-PATENCY-ASSESSMENT

    CPT 58350: Chromotubation (Fallopian Tube Patency Test)

    CPT-58353-THERMAL-ENDOMETRIAL-ABLATION-WITHOUT-HYSTEROSCOPY

    CPT 58353: Thermal Endometrial Ablation Without Hysteroscopic Guidance

    CPT-58356-ENDOMETRIAL-CRYOABLATION-UTERINE-BLEEDING

    CPT 58356: Endometrial Cryodestruction with Ultrasound Guidance

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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