Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.30
    OpenPayerBilling CodesTransplantation and Post-Transplantation Cellular Infusion Procedures on the Hemic and Lymphatic SystemsCPT cpt-38240-donor-hematopoietic-progenitor-cell-infusion
    Ask Trek AI about this page

    CPT 38240: Allogeneic Hematopoietic Progenitor Cell Transplantation

    Medicare pays $207 on average nationally for this procedure.

    CPT code 38240 describes the allogeneic hematopoietic progenitor cell transplantation procedure in which a provider introduces into a recipient’s bloodstream hematopoietic progenitor cells harvested from another donor; this is a cellular therapy infusion typically performed as a therapeutic transplant procedure in an inpatient hospital or specialty transplant center setting and involves infusion of donor-derived hematopoietic cells for hematologic reconstitution.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

    Customize your policy alerts

    Sign up for cpt 38240 policy alerts

    Get alerted when payer policies referencing 38240 are released or updated.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • Facility ComparisonBeds, revenue & payer mix
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old recipient with relapsed acute myeloid leukemia receives an allogeneic hematopoietic progenitor cell transplant following conditioning chemotherapy. Donor cells were collected from a matched related donor and transported to the transplant center. On the day of infusion, the recipient is evaluated in the hematopoietic stem cell transplant unit, venous access is confirmed (central venous catheter), transfusion consent reviewed, premedications (acetaminophen, diphenhydramine, and corticosteroid as indicated) administered, and vital signs documented. The provider infuses donor-derived hematopoietic progenitor cells into the recipient intravenously under continuous monitoring for acute infusion reactions, with supportive orders standing for management of hypotension, allergic reaction, or cytokine release. Post-infusion monitoring continues for several hours with documentation of cell dose, donor identification, product lot number, and any adverse events. Typical site of service is an inpatient hospital transplant unit or an ambulatory infusion/transplant center depending on institutional protocol. Service type is an allogeneic hematopoietic progenitor cell infusion (transplant) procedure coded as 38240.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38205Peripheral blood hematopoietic progenitor cell (HPC), apheresis; allogeneic transplant collection from donorDonor collection procedure that precedes 38240 when peripheral blood stem cells are used.
    38206Peripheral blood hematopoietic progenitor cell (HPC), apheresis; autologous transplant collection from donorDonor collection for autologous products; related when autologous grafts are infused instead of allogeneic.
    38241Transplantation of hematopoietic progenitor cells, allogeneic; cellular subset selection (eg, CD34 selection)Laboratory or processing procedure performed on the graft prior to infusion to modify cellular composition.
    36415Collection of venous blood by venipunctureCommon ancillary service for pre-infusion testing and crossmatch specimens.
    36430Transfusion or infusion of blood productsRelated infusion codes for supportive blood product administration that may occur before, during, or after 38240.
    36556Insertion of tunneled centrally inserted central venous catheter, with subcutaneous port or pump, without subcutaneous portVascular access procedures required for administration of HPCs in many transplant recipients.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    2084P0800X
    207RC0000X
    163W00000X
    163WX0003X
    122400000X
    2085N0904X
    332B00000X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-38241-AUTOLOGOUS-HEMATOPOIETIC-PROGENITOR-CELL-REINFUSION

    CPT 38241: Autologous Hematopoietic Progenitor Cell Reinfusion

    CPT-38242-ADOPTIVE-LYMPHOCYTE-TRANSFER

    CPT 38242: Allogeneic Lymphocyte Infusion for Recurrent Infection

    CPT-38243-DONOR-DERIVED-HEMATOPOIETIC-PROGENITOR-CELL-INFUSION

    CPT 38243: Infusion of Donor-Derived Hematopoietic Progenitor Cells

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.