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    v1.0.30
    OpenPayerBilling CodesTransplantation and Post-Transplantation Cellular Infusion Procedures on the Hemic and Lymphatic SystemsCPT cpt-38241-autologous-hematopoietic-progenitor-cell-reinfusion
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    CPT 38241: Autologous Hematopoietic Progenitor Cell Reinfusion

    Medicare pays $153 on average nationally for this procedure.

    CPT code 38241 describes reinfusion of a patient’s own hematopoietic progenitor cells (autologous HPCs) previously harvested from the patient; the service is a cellular therapy infusion procedure typically performed in an inpatient or outpatient infusion center or bone marrow transplant unit and is classified as autologous hematopoietic progenitor cell reinfusion.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 25–50-year-old adult undergoing autologous hematopoietic progenitor cell (HPC) infusion, where the provider reintroduces hematopoietic progenitor cells harvested previously from the same patient into the patient’s bloodstream. Common indications include hematologic malignancies (for example, relapsed lymphoma or multiple myeloma) following myeloablative or reduced-intensity conditioning, or recovery of bone marrow function after high-dose chemotherapy. The clinical workflow includes: pre-procedure evaluation (confirm cell product identity, infectious disease testing, crossmatch if indicated, and review of conditioning regimen timing), vascular access assessment (existing central venous catheter or placement), intravenous infusion of the HPC product under monitored conditions with vital sign and transfusion-reaction surveillance, post-infusion observation for immediate reactions, and coordination with the transplant team for inpatient monitoring of engraftment and supportive care. Typical site of service is an inpatient transplant unit or an ambulatory transplant infusion center depending on conditioning and institutional protocol. The service type is an autologous hematopoietic progenitor cell infusion derived from the patient’s own previously harvested cells.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38240Hematopoietic progenitor cell (HPC); allogeneic transplantation per donorWorks as the allogeneic counterpart to 38241; used when donor-derived cells are infused instead of autologous cells
    38242Hematopoietic progenitor cell (HPC); collection from a donor for transplantationPerformed before infusion when cells are collected from a donor; relevant in the broader transplant workflow
    36556Collection of blood specimen from a central venous catheter, percutaneous, without subcutaneous portMay be used for product sampling or pre-infusion testing related to vascular access
    36561Insertion of tunneled centrally inserted central venous catheter, with cuffOften performed prior to HPC infusion to provide long-term vascular access for infusion and supportive care
    86816Crossmatch test, each unit; compatibility testing for transplantationUsed for compatibility testing or infectious disease/product testing associated with cellular therapy
    36569Replacement, removal and reinsertion of central venous catheter, without subcutaneous portPerformed if existing vascular access is inadequate and must be revised before infusion

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    2084P0800X
    363L00000X
    207L00000X
    2084P0805X
    211D00000X
    207ZB0001X
    364SX0200X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C81.90Hodgkin lymphoma, unspecified, unspecified site
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C84.90Mature T/NK-cell lymphomas, unspecified, unspecified site
    C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
    C90.00Multiple myeloma not having achieved remission
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C91.02Acute lymphoblastic leukemia, in relapse
    C92.00Acute myeloblastic leukemia, not having achieved remission
    C92.10Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
    C95.90Leukemia, unspecified not having achieved remission

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-38240-DONOR-HEMATOPOIETIC-PROGENITOR-CELL-INFUSION

    CPT 38240: Allogeneic Hematopoietic Progenitor Cell Transplantation

    CPT-38242-ADOPTIVE-LYMPHOCYTE-TRANSFER

    CPT 38242: Allogeneic Lymphocyte Infusion for Recurrent Infection

    CPT-38243-DONOR-DERIVED-HEMATOPOIETIC-PROGENITOR-CELL-INFUSION

    CPT 38243: Infusion of Donor-Derived Hematopoietic Progenitor Cells

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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