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    v1.0.31
    OpenPayerBilling CodesBone Marrow or Stem Cell Services/ProceduresCPT cpt-38207-hematopoietic-progenitor-cell-preservation-storage
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    CPT 38207: Management of Hematopoietic Progenitor Cell Preservation

    CPT code 38207 describes the provider service managing preservation and storage of harvested hematopoietic progenitor cells (HPCs) for future transplantation; this service involves overseeing cell processing, assurance of preservation according to protocols, and arranging storage logistics. Service type: HPC preservation and storage management. Typical site of service: hospital or specialized cellular therapy laboratory/processing facility.

    For related coverage guidance, see recent payer policy updates: Bendamustine Products Coverage Criteria, T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Brentuximab Vedotin (Adcetris®) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult or pediatric candidate for autologous or allogeneic hematopoietic progenitor cell (HPC) transplantation, such as a patient with hematologic malignancy (e.g., acute leukemia, lymphoma, or multiple myeloma) who has undergone mobilization and apheresis to collect peripheral blood stem cells or a patient who had bone marrow harvest. After collection, a transplantation physician, affiliated transplant coordinator, or cellular therapy specialist manages processing, cryopreservation, storage, and documentation of the harvested HPC product. The clinical workflow includes receipt of the collected product from the apheresis or operating room team, verification of donor/patient identifiers, assessment of product volume and cell counts, addition of cryoprotectant (commonly dimethyl sulfoxide), controlled-rate freezing per institutional protocol, labeling and chain-of-custody documentation, placement into long-term cryogenic storage, and ongoing inventory and release management for future infusion. The service is typically performed in an inpatient or outpatient hospital-based transfusion/cell-processing laboratory, a dedicated cellular therapy processing facility, or a hospital blood bank with cryopreservation capabilities. Billing occurs when the provider assumes responsibility for preservation and storage oversight according to protocols in anticipation of future transplantation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38206Collection of hematopoietic progenitor cells; per collection, for autologous or allogeneic peripheral blood stem cell collection via apheresisPerformed before preservation; provides the product that is then preserved and stored under 38207.
    38208Immunologic or cell therapy processing not otherwise classified; manipulation of hematopoietic progenitor cells for specified processing (e.g., CD34 selection)May be performed prior to cryopreservation if cell selection or manipulation is required before storage.
    36415Collection of venous blood by venipunctureAncillary blood sampling for crossmatch, infectious disease testing, and cell counts before or after collection and preservation.
    86850Crossmatch; blood, compatibility testingPre-release testing often required before infusion of preserved HPCs; related to product release and storage documentation.
    38214Transplantation of hematopoietic progenitor cells (HPC), allogeneic, bone marrow or blood-derived, per donor; harvesting is includedRelated upstream procedure when bone marrow harvest is the source; preservation follows harvest and is reported under 38207.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    2080P0207X
    163W00000X
    207L00000X
    163WM0102X
    225C00000X
    305S00000X
    1744G0900X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C25.9Malignant neoplasm of pancreas, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C56.9Malignant neoplasm of unspecified ovary
    C71.9Malignant neoplasm of brain, unspecified
    C81.90Hodgkin lymphoma, unspecified, unspecified site
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C84.60Anaplastic large cell lymphoma, ALK-positive, unspecified site
    C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
    C90.00Multiple myeloma not having achieved remission
    C90.01Multiple myeloma in remission

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Bendamustine Products Coverage Criteriablue cross blue shield - tennessee2027-01-30
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Brentuximab Vedotin (Adcetris®) Coverage Criteriablue cross blue shield - tennessee2026-12-31
    Pemetrexed Coverageblue cross blue shield - tennessee2026-12-31
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    VonvendiCigna2026-11-15
    Hematology - AphexdaCigna2026-11-15
    Extracorporeal PhotopheresisCigna2026-11-15
    Yartemlea (narsoplimab-wuug) Coverage for TA-TMANeighborhood Health Plan of Rhode Island2026-11-01

    Related Codes

    CPT-38204-DONOR-SEARCH-HPC-ACQUISITION-MANAGEMENT

    CPT 38204: Donor Search and Hematopoietic Progenitor Cell Acquisition

    CPT-38205-APHERESIS-HPC-PERIPHERAL-BLOOD-HARVEST

    CPT 38205: Apheresis Hematopoietic Progenitor Cell Harvest

    CPT-38206-AUTOLOGOUS-HPC-APHERESIS-COLLECTION

    CPT 38206: Autologous Hematopoietic Progenitor Cell Apheresis

    CPT-38208-THAW-PREPARATION-HEMATOPOIETIC-PROGENITOR-CELLS

    CPT 38208: Thawing of Previously Frozen Hematopoietic Progenitor Cells

    CPT-38209-HPC-THAWING-AND-WASHING-FOR-TRANSPLANTATION

    CPT 38209: Thaw and Wash Hematopoietic Progenitor Cells for Transplant

    CPT-38210-T-CELL-DEPLETED-HEMATOPOIETIC-PROGENITOR-CELL-PREPARATION

    CPT 38210: T-Cell–Reduced Hematopoietic Progenitor Cell Preparation

    CPT-38211-HEMATOPOIETIC-PROGENITOR-CELL-TUMOR-REDUCTION-PROCESSING

    CPT 38211: Hematopoietic Progenitor Cell Enrichment and Tumor Depletion

    CPT-38212-HPC-RED-CELL-DEPLETION-PREPARATION

    CPT 38212: HPC Red Cell Depletion for Transplant Preparation

    CPT-38213-HPC-SOLUTION-PREPARATION-PLATELET-REDUCTION

    CPT 38213: Hematopoietic Progenitor Cell Preparation to Reduce Platelets

    CPT-38214-HPC-MINIMAL-PLASMA-VOLUME-PREPARATION

    CPT 38214: Preparation of HPCs to Minimal Plasma Volume

    Showing 1–10 of 20

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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