Summary & Overview
CPT 0201U: Navigator YT Sequencing for YT Blood Group Antigen Typing
CPT code 0201U is a Proprietary Laboratory Analyses (PLA) code for the Navigator YT Sequencing test from Grifols Immunohematology Center that identifies YT blood group antigens through targeted gene sequence analysis. The test supports clinical decision-making in transfusion medicine, transplantation, and perinatal care by reducing the risk of antigen incompatibility–related reactions. Nationally, such specialized PLA codes matter because they represent single-source laboratory tests with potential implications for clinical workflows, coding practices, and payer coverage policies.
Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of clinical context and the role of YT antigen testing, a summary of payer coverage considerations, and what to expect in terms of billing classification and service setting. The publication also outlines common modifiers associated with laboratory molecular testing and notes where input data is not available. The content is intended to inform billing staff, laboratory administrators, and policy analysts about the clinical purpose of CPT code 0201U, typical sites of service, and the payer landscape relevant to this PLA-coded sequencing assay.
Billing Code Overview
CPT code 0201U is a Proprietary Laboratory Analyses (PLA) code for the Navigator YT Sequencing test from Grifols Immunohematology Center. The test analyzes specific gene sequences to determine YT blood group antigens, information that can help clinicians minimize adverse blood–type incompatibility reactions in blood transfusions, organ transplants, and in pregnancy and newborn care.
Service type: Genetic sequencing / molecular diagnostic test for blood group antigen typing
Typical site of service: Clinical laboratory or hospital laboratory
Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.
Clinical & Coding Specifications
Clinical Context
A 32-year-old pregnant woman with a prior history of transfusion and an inconclusive serologic Yt blood group typing is referred for molecular genotyping. The obstetrician orders the Navigator YT Sequencing test from Grifols Immunohematology Center to determine YT antigen status from a maternal blood specimen to assess fetal/newborn hemolytic risk and to guide selection of compatible blood products if transfusion is needed. Blood is drawn in a phlebotomy setting and sent to the reference laboratory; results are reported to the ordering provider and transfusion medicine service. This test is also used pre-transplant and pre-transfusion when serologic results are discrepant or when patient has been recently transfused and phenotype is indeterminate.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | Modifier not used/placeholder (manufacturer-specific PLA guidance) | Rarely used; present in input list but not typically appended to PLA codes for professional/technical split billing |
11 | Office or other outpatient service/standard billing | Use when test performed and billed under routine circumstances without unusual procedural services |
26 | Professional component | Use when only the professional interpretation component is billed separately from technical lab work |
TC | Technical component | Use when only the laboratory technical component (performing the test) is billed |
52 | Reduced services | Use when test performed at a reduced scope or limited by specimen quality |
53 | Discontinued procedure | Use if specimen collection or processing was started but testing not completed for clinical reasons |
78 | Unplanned return to the operating/procedure room | Not commonly applicable to lab testing; included when related to a procedural episode with return to OR |
80 | Assistant surgeon | Not applicable to lab testing; rarely used in associated surgical workflows |
QK | CLIA waived test performed at point of care by non-lab personnel — not applicable | Included for completeness from input list; not typically used for this PLA |
QX | Ordering physician qualifier — diagnostic laboratory services | Use when delineation of services performed by a qualified laboratory practitioner is required in certain payer contexts |
QY | Billing of diagnostic tests by independent laboratory | Use when independent reference lab bills for the diagnostic test |
SH | Service provided in a non-patient facility | Use if specimen collected and test performed in a non-patient care setting per payer rules |
SJ | Service provided in a portable x-ray — not applicable | Included from input list though not relevant to this lab assay |
TG | For reporting of specimen picked up — transport related | Use when specimen transport or courier services require separate reporting per payer |
| Taxonomy Code | Specialty | Notes |
|---|---|---|
| 208000000X | Clinical Laboratory | Performs and interprets molecular immunohematology testing |
| 207Q00000X | Pathology and Laboratory Medicine | Oversight and interpretation of specialized blood group genotyping |
| 208800000X | Transfusion Medicine | Clinical application of results for transfusion and compatibility decisions |
| 207L00000X | Medical Genetics | Oversight when genotyping has broader genetic counseling implications |
Related Diagnoses
| ICD-10 Code | Description | Clinical Relevance |
|---|---|---|
O36.80 | Maternal care for other specified fetal problems, unspecified trimester | Used when maternal evaluation is needed for potential fetal hemolytic disease or blood group incompatibility |
D68.49 | Other hemorrhagic conditions (includes alloimmune hemolytic anemia of fetus and newborn) | Relevant for assessing immune-mediated hemolysis risk related to maternal antibodies against YT antigens |
Z31.83 | Encounter for genetic counseling | Relevant when molecular blood group results have implications for future pregnancy planning |
Z51.89 | Encounter for other specified aftercare (including transfusion planning) | Used when results inform transfusion strategy for the patient |
Z51.0 | Encounter for antineoplastic radiation therapy — not typically related but included only if oncology transfusion planning is needed | Rarely applicable; included when complex transfusion support required during cancer care |
Related CPT Codes
| CPT Code | Description | Relationship to This Procedure |
|---|---|---|
0201U | Navigator YT Sequencing test (Proprietary Laboratory Analyses) | Primary PLA code for YT blood group genotyping performed by Grifols Immunohematology Center |
81265 | HLA-B locus analysis (sequence analysis) | Example molecular typing often ordered in transfusion and transplant workups alongside blood group genotyping |
81266 | HLA-C locus analysis (sequence analysis) | Additional molecular compatibility testing commonly part of pre-transplant evaluation |
87899 | Unlisted molecular pathology procedure | Used rarely when an associated molecular test lacks a specific CPT and is performed in conjunction with PLA testing |
36415 | Collection of venous blood by venipuncture | Specimen collection CPT commonly performed prior to sending sample to reference lab |