Infertility Services (ART, IUI/ICI, IVF, donor gametes, preservation)
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Governs coverage and medical necessity criteria for infertility treatments including artificial insemination (IUI/ICI), in vitro fertilization (IVF) and related services for members of Blue Cross Blue Shield - Rhode Island under the Standard Infertility Services Benefit; notes differences for self-funded expanded plans.
No material clinical or coverage changes in this revision.
Coverage and Medical Necessity Criteria
Eligibility Criteria — Members Assigned Female at Birth (AFAB)
Covered when ALL of the following groups (1, 2 and 3) are satisfied:
AFAB eligibility
- Duration or AI cycles or specific diagnoses: One of: (a) documented inability to conceive after 1 year of unprotected intercourse with exposure to sperm (or 6 months if age ≥35); OR (b) inability to conceive after 3 consecutive artificial insemination (AI) cycles (ICI or IUI) performed by a qualified specialist; OR (c) documented infertility due to tubal factor, pelvic adhesive disease, or endometriosis.
For members who miscarried, prior time attempting to conceive counts toward the required duration.
- Health status: Member attempting to conceive must be presumably healthy without a history of prior sterilization (or reversal).
- Menopause exclusion: Postmenopausal state must not be the cause of infertility, unless the member is under age 43 with premature ovarian failure.
Eligibility Criteria — Members Assigned Male at Birth (AMAB)
Coverage for male-factor treatments is available when documented parameters and stated indications are met:
Medical necessity criteria by service
Covered when ALL of the following are met for the listed service types:
If requested after 4 cycles, additional documentation per 'After 4 In Vitro Fertilization (IVF) Cycles' is required.
If requested after 4 cycles, see 'After 4 In Vitro Fertilization (IVF) Cycles'.
If requested after 4 cycles, see 'After 4 In Vitro Fertilization (IVF) Cycles'.
After 4 In Vitro Fertilization (IVF) Cycles
After four completed IVF cycles without pregnancy and delivery, ALL of the following must be provided for further transfer procedures to be considered:
All three items must be supplied for review and approval of additional transfer procedures.
Selected medical necessity and evidence stances
Selected policy-level coverage and evidence stances:
From policy text regarding donor sperm and procurement.
Based on evidence summaries in the policy.
Evidence-based statements and indicated medically necessary procedures
Evidence-based statements and procedures the policy considers medically necessary in specified indications:
Co-culture not supported by controlled evidence.
Evidence insufficient for benefit.
Iatrogenic Infertility — Cryopreservation and Storage
Cryopreservation, storage and thawing services are medically necessary when ALL of the iatrogenic infertility criteria are met:
When iatrogenic infertility criteria are not met these codes are not covered.
Cryopreservation, Storage and Thawing
Covered when the medical necessity criteria of iatrogenic infertility are met:
Claims for multiyear storage or storage beyond 12 months are not covered; coverage is limited to one year (12 months) per benefit year.
Diagnostic Evaluation of Infertility
Diagnostic evaluation services that are covered (these are considered diagnostic and not part of the infertility benefit):
These services are covered under applicable diagnostic benefits and are not counted as part of the infertility cycle benefit.
Diagnostic Evaluation of Infertility - Covered Services
Covered diagnostic services for evaluation of infertility include:
Codes include 89300, 89310, 89320, 89321, 89322, 89325, 89329, and 89261.
Diagnostic Evaluation — covered services
Covered diagnostic evaluations (as listed):
The policy enumerates codes but does not attach separate medical-necessity decision logic to these diagnostic codes.
Diagnostic Evaluation - Covered Codes
Covered when billed using the listed procedure and laboratory codes:
See coding section for the full code list (examples include 89300–89331, 58350, 58750).
Diagnostic Evaluation - Covered Codes
Covered diagnostic infertility evaluation services (listed codes):
These services are billed under diagnostic benefits and not as part of the infertility treatment case-rate.
The policy excludes payment for the cost of donor sperm procurement, processing, and storage. While related implantation services provided as part of infertility treatment may be submitted to BCBSRI for reimbursement, charges associated with obtaining donor sperm (the procurement/processing/storage fees) are not covered.
The policy states that home artificial insemination (AI) — including member-performed intracervical insemination (ICI) or home intrauterine insemination (IUI) — is not a covered service. Covered AI cycles are those performed under the plan benefit (for example, the documented three clinical AI cycles described elsewhere); self-administered home AI cycles are excluded.
The policy treats normal menopause as a nonmedical condition for eligibility purposes. Members who have undergone normal menopause do not meet the plan's eligibility criteria for infertility services; an elevated FSH and amenorrhea after age 42 are considered normal menopause under this policy, whereas menopause occurring prior to age 42 is not considered normal menopause.
Charges billed by an egg donation facilitation agency are not covered. The policy specifies that fees associated with locating or contracting with an egg donor — including donor transportation costs that some agencies cover — are not reimbursable. Once a donor is identified, clinical services such as egg retrieval and implantation-related procedures may be submitted for reimbursement, but facilitation/agency fees and donor travel are excluded.
Fees charged by egg donation facilitation agencies — including costs related to donor identification, donor stipends, and donor transportation — are explicitly not covered. The policy distinguishes these facilitation/agency charges from clinical services (e.g., egg retrieval) that, once performed, may be billed to BCBSRI.
Infertility services requested for a member who previously underwent voluntary sterilization are generally excluded from coverage. Such requests will undergo clinician review; coverage may only be considered when review documents that the prior sterilization is unrelated to the current inability to conceive. Otherwise the contractual exclusion applies and services will be administratively denied.
Cryopreservation, storage, and thawing of embryos, sperm, or reproductive tissues are not covered unless the member meets the medical necessity criteria for iatrogenic infertility. The codes for cryopreservation and associated storage/thawing are designated medically necessary only when iatrogenic infertility criteria are satisfied; for all other members these services are excluded.
The policy identifies reversal of voluntary sterilization as a noncovered service. Additionally, services related to surrogate parenting are excluded when the surrogate is not a plan member; fees associated with donor facilitation or surrogate arrangements (when the surrogate is not covered) are not payable by the plan.
Home artificial insemination cycles performed by the member (ICI or IUI at home) are explicitly listed as not covered. Clinical AI cycles performed under the benefit (documented and provider-administered ICI/IUI) differ from home AI and are addressed elsewhere in the policy.
All services related to surrogate parents are excluded from coverage when the surrogate is not a member of this plan. The policy defines surrogacy and clarifies that gestational or traditional surrogate services will not be paid if the surrogate herself is not covered under the member's plan.
As noted elsewhere, services related to surrogate parenting are not covered when the surrogate is not a plan member. This reiterates the exclusion for surrogate-associated services in cases where the surrogate does not have plan coverage.
The coding section enumerates procedure and case-rate codes that require prior authorization for IVF cycles; there are no separate, additional exclusions listed in this part of the coding section beyond the listed PA requirements.
For members who do not meet the medical necessity criteria for iatrogenic infertility, cryopreservation, storage, and thawing codes are not covered. The policy conditions coverage of these services on documented medical necessity that reproductive capacity will be impaired by planned medical treatment.
The policy limits storage coverage to one benefit year: multiyear storage or storage beyond 12 months is not covered. Even when iatrogenic infertility criteria are met, claims for storage longer than 12 months (multiyear storage) will be denied; coverage is available up to one year (12 months) per benefit year.
This restates that multiyear storage or any storage period exceeding 12 months is not covered; coverage of storage is limited to a maximum of 12 months per benefit year and multiyear storage claims will be denied.
The diagnostic evaluation sections (as presented in these chunks) primarily list covered diagnostic procedure and laboratory codes; they do not contain explicit exclusion language in the excerpted diagnostic code listings.
The diagnostic code listings provided here enumerate covered semen analyses and related tests; within these chunks no explicit exclusions are stated beyond those detailed elsewhere in the policy.
These diagnostic evaluation excerpts focus on covered semen analysis and related procedures; no explicit exclusionary language is present in this portion of the document.
This excerpt reiterates covered diagnostic procedure and lab codes for infertility evaluation; the text shown does not include explicit exclusions and largely repeats the covered code list.
The listed diagnostic code blocks present covered semen analyses, sperm functional tests, and tubal procedures; the content is a repetitive listing of covered codes and does not explicitly provide exclusionary statements within these chunks.
MESA and TESE are designated as not covered when the chance of live birth is less than 5%. Requests for these sperm-retrieval procedures should document the predicted probability of live birth; if that probability is under 5%, the policy states these services are not payable.
EmbryoGlue® (hyaluronic-acid–enriched transfer medium, CPT 89398) is considered not medically necessary. The policy concludes that current evidence is insufficient to show improved live birth outcomes with EmbryoGlue and therefore it is not supported as medically necessary.
The Hyaluronan Binding Assay for sperm evaluation is explicitly not covered for Medicare Advantage plans and is considered not medically necessary for Commercial products due to insufficient evidence of improved health outcomes.
The policy notes that adjunct laboratory techniques such as EmbryoGlue, assisted hatching, and embryo co-culture lack sufficient evidence of improved live birth rates. Assisted hatching has not demonstrated a consistent live birth benefit in RCTs and meta-analyses, EmbryoGlue trials have not shown an improvement in live birth, and embryo co-culture lacks controlled-trial evidence and a standardized method; collectively these techniques are not supported as established, effective therapies.
Embryo co-culture is specifically noted as having no controlled trials demonstrating improved implantation or pregnancy rates and no standardized method; as a result the policy does not support co-culture as an effective intervention.
The document reiterates that cryopreservation, storage, and thawing codes are not covered for members who do not meet the iatrogenic infertility criteria. Coverage for these services is conditional on documented risk of iatrogenic infertility; absent that medical necessity, such claims will be denied.
CPT / HCPCS Code Groups
| 89398 | EmbryoGlue® |
| 89398 | EmbryoGlue® (hyaluronic acid) |
| 58970 | Follicle puncture for oocyte retrieval, any method |
| 58974 | Embryo transfer, intrauterine |
| 58976 | Gamete, zygote or embryo intrafallopian transfer, any method |
| 76948 | Ultrasonic guidance for aspiration of ova, imaging supervision and interpretation |
| 89250 | Culture of oocyte(s)/embryo(s), less than 4 days |
| 89251 | Culture of oocyte(s)/embryo(s), less than 4 days; with co-culture of oocyte(s)/embryo(s) |
| 89253 | Assisted embryo hatching, microtechniques (any method) |
| 89254 | Oocyte identification from follicular fluid |
| 89280 | Assisted oocyte fertilization, microtechnique; less than or equal to 10 oocytes |
| 89281 | Assisted oocyte fertilization, microtechnique; greater than 10 oocytes |
| S4011 | In vitro fertilization; including but not limited to identification and incubation of mature oocytes, fertilization with sperm, incubation of embryo(s), and subsequent visualization for determination of development |
| S4013 | Complete cycle, gamete intrafallopian transfer (GIFT), case rate |
| S4014 | Complete cycle, zygote intrafallopian transfer (ZIFT), case rate |
| S4015 | Complete in vitro fertilization cycle, not otherwise specified, case rate |
| S4016 | Frozen in vitro fertilization cycle, case rate |
| S4017 | Incomplete cycle, treatment cancelled prior to stimulation, case rate |
| S4011 | In vitro fertilization; including but not limited to identification and incubation of mature oocytes, fertilization with sperm, incubation of embryo(s), and subsequent visualization for determination of development |
| S4013 | Complete in vitro fertilization cycle, not otherwise specified, case rate |
| S4014 | Complete cycle, gamete intrafallopian transfer (GIFT), case rate |
| S4015 | Complete cycle, zygote intrafallopian transfer (ZIFT), case rate |
| S4016 | Frozen in vitro fertilization cycle, case rate |
| S4017 | Incomplete cycle, treatment cancelled prior to stimulation, case rate |
| S4018 | Frozen embryo transfer procedure cancelled before transfer, case rate (NSR) |
| S4020 | In vitro fertilization procedure cancelled before aspiration, case rate |
| 89280 | Assisted oocyte fertilization, microtechnique; greater than 10 oocytes |
| 89281 | Assisted oocyte fertilization, microtechnique |
| S4013 | Complete cycle, gamete intrafallopian transfer (GIFT), case rate |
| S4014 | Complete cycle, zygote intrafallopian transfer (ZIFT), case rate |
| S4015 | Complete in vitro fertilization cycle, not otherwise specified, case rate |
| S4016 | Frozen in vitro fertilization cycle, case rate |
| S4017 | Incomplete cycle, treatment cancelled prior to stimulation, case rate |
| S4018 | Frozen embryo transfer procedure cancelled before transfer, case rate (NSR) |
| S4020 | In vitro fertilization procedure cancelled before aspiration, case rate |
| S4021 | In vitro fertilization procedure cancelled after aspiration, case rate |
| S4013 | Complete cycle, gamete intrafallopian transfer (GIFT), case rate |
| S4014 | Complete cycle, zygote intrafallopian transfer (ZIFT), case rate |
| S4015 | Complete in vitro fertilization cycle, not otherwise specified, case rate |
| S4016 | Frozen in vitro fertilization cycle, case rate |
| S4017 | Incomplete cycle, treatment cancelled prior to stimulation, case rate |
| S4018 | Frozen embryo transfer procedure cancelled before transfer, case rate |
| S4020 | In vitro fertilization procedure cancelled before aspiration, case rate |
| S4021 | In vitro fertilization procedure cancelled after aspiration, case rate |
| S4022 | Assisted oocyte fertilization, case rate |
| S4023 | Assisted oocyte fertilization, case rate (additional) |
| 89258 | Cryopreservation; embryo(s) |
| 89259 | Cryopreservation; sperm |
| 89335 | Cryopreservation, reproductive tissue, testicular |
| 89337 | Cryopreservation, mature oocyte(s) |
| 89342 | Storage (per year); embryo(s) |
| 89343 | Storage (per year); sperm/semen |
| 89344 | Storage (per year); reproductive tissue, testicular/ovarian |
| 89346 | Storage (per year); oocyte |
| 89354 | Thawing of cryopreserved; reproductive tissue; testicular/ovarian |
| 89356 | Thawing of cryopreserved; oocytes, each aliquot |
| 89258 | Cryopreservation; embryo(s) |
| 89259 | Cryopreservation; sperm |
| 89335 | Cryopreservation, reproductive tissue, testicular |
| 89337 | Cryopreservation, mature oocyte(s) |
| 89342 | Storage (per year); embryo(s) |
| 89343 | Storage (per year); sperm/semen |
| 89344 | Storage (per year); reproductive tissue, testicular/ovarian |
| 89346 | Storage (per year); oocyte |
| 89354 | Thawing of cryopreserved; reproductive tissue; testicular/ovarian |
| 89356 | Thawing of cryopreserved; oocytes, each aliquot |
| 55200 | Vasotomy, cannulization with or without incision of Vas, unilateral or bilateral (separate procedure) |
| 58321 | Artificial insemination; intra-cervical |
| 58322 | Artificial insemination; intra-uterine |
| 58323 | Sperm washing for artificial insemination |
| 58350 | Chromotubation of oviduct, including materials |
| 58750 | Tubotubal anastomosis |
| 89260 | Sperm isolation; simple prep (e.g., sperm wash and swim-up) for insemination or diagnosis with semen analysis |
| 89261 | Sperm isolation; complex prep (e.g., Percoll gradient, albumin gradient) for insemination or diagnosis with semen analysis |
| 89300 | Semen analysis; presence and/or motility of sperm including Huhner test (post coital) (lab) |
| 89310 | Semen analysis; motility and count (not including Huhner test) (lab) |
| 89300 | Semen analysis; presence and/or motility of sperm including Huhner test (post coital) (lab) |
| 89310 | Semen analysis; motility and count (not including Huhner test) (lab) |
| 89320 | Semen analysis; complete (volume, count, motility and differential) (lab) |
| 89321 | Semen analysis, presence and/or motility of sperm |
| 89322 | Semen analysis: volume, count, and differential using strict morphologic criteria (e.g.,Kruger) (lab) |
| 89325 | Sperm antibodies (lab) |
| 89261 | Sperm isolation; complex prep (e.g., Percoll gradient, albumin gradient) for insemination or diagnosis with semen analysis |
| 58350 | Chromotubation of oviduct, including materials |
| 58750 | Tubotubal anastomosis |
| 89300 | Semen analysis; presence and/or motility of sperm including Huhner test (post coital) (lab) |
| 89310 | Semen analysis; motility and count (not including Huhner test) (lab) |
| 89320 | Semen analysis; complete (volume, count, motility and differential) (lab) |
| 89321 | Semen analysis, presence and/or motility of sperm |
| 89322 | Semen analysis: volume, count, and differential using strict morphologic criteria (e.g.,Kruger) (lab) |
| 89325 | Sperm antibodies (lab) |
| 89329 | Sperm evaluation; hamster penetration test (lab) |
| 89261 | Sperm isolation; complex prep (e.g., Percoll gradient, albumin gradient) for insemination or diagnosis with semen analysis |
| 58350 | Chromotubation of oviduct, including materials |
| 58750 | Tubotubal anastomosis |
| 89300 | Semen analysis; presence and/or motility of sperm including Huhner test (post coital) (lab) |
| 89310 | Semen analysis; motility and count (not including Huhner test) (lab) |
| 89320 | Semen analysis; complete (volume, count, motility and differential) (lab) |
| 89321 | Semen analysis, presence and/or motility of sperm |
| 89322 | Semen analysis: volume, count, and differential using strict morphologic criteria (e.g.,Kruger) (lab) |
| 89325 | Sperm antibodies (lab) |
| 89329 | Sperm evaluation; hamster penetration test (lab) |
| 89330 | Sperm evaluation; cervical mucus penetration test, with or without spinnbarkeit test (lab) |
| 58350 | Chromotubation of oviduct, including materials |
| 58750 | Tubotubal anastomosis |
| 89300 | Semen analysis; presence and/or motility of sperm including Huhner test (post coital) (lab) |
| 89310 | Semen analysis; motility and count (not including Huhner test) (lab) |
| 89320 | Semen analysis; complete (volume, count, motility and differential) (lab) |
| 89321 | Semen analysis, presence and/or motility of sperm |
| 89322 | Semen analysis: volume, count, and differential using strict morphologic criteria (e.g.,Kruger) (lab) |
| 89325 | Sperm antibodies (lab) |
| 89329 | Sperm evaluation; hamster penetration test (lab) |
| 89330 | Sperm evaluation; cervical mucus penetration test, with or without spinnbarkeit test (lab) |
| 89331 | Code listed in document (no description provided in excerpt) |
| 58350 | Chromotubation of oviduct, including materials |
| 89300 | Semen analysis; presence and/or motility of sperm (including Huhner test) (lab) |
| 89310 | Semen analysis; presence and/or motility of sperm including Huhner test (post coital) (lab) |
| 89320 | Semen analysis; motility and count (not including Huhner test) (lab) |
| 89321 | Semen analysis; complete (volume, count, motility and differential) (lab) |
| 89322 | Semen analysis; presence and/or motility of sperm |
| 89325 | Semen analysis: volume, count, and differential using strict morphologic criteria (e.g.,Kruger) (lab) |
| 89329 | Sperm antibodies (lab) |
| 89330 | Sperm evaluation; hamster penetration test (lab) |
| 89331 | Sperm evaluation; cervical mucus penetration test, with or without spinnbarkeit test (lab); also listed for urine sperm evaluation for retrograde ejaculation |
| 58350 | Chromotubation of oviduct, including materials |
Prior Authorization, Documentation, and Billing Guidance
Prior authorization may be required
Some infertility services require prior authorization after eligibility is confirmed because Medical Necessity Criteria must also be satisfied; check PA rules before scheduling services.
- Prior authorization may be required even when eligibility criteria are met.
Prior authorization required for IVF and related services
Prior authorization is required for IVF cycles (complete, partial, incomplete), components of IVF (retrieval, fertilization, ICSI, transfers, MESA/TESE/TESA), donor egg cycles, frozen cycles, and services related to iatrogenic infertility (cryopreservation, storage, monitoring, thawing). PA is required for Medicare Advantage and recommended for Commercial products.
- IVF cycles (complete/partial/incomplete) and components (oocyte retrieval, assisted fertilization, embryo incubation/transfer, SET/MET, donor services, ICSI, MESA/TESE/TESA)
- Services related to iatrogenic infertility (cryopreservation, storage, monitoring, thawing)
Clinical review and claim submission for sterilization-related cases
Requests for infertility services where prior sterilization may be relevant will be reviewed by a clinician; a determination that the contractual sterilization exclusion applies is an administrative denial (not a medical necessity determination).
- Clinician review required for members with prior sterilization; administrative denial possible if exclusion applies.
- Submit implantation-related services for reimbursement to BCBSRI as directed.
IVF cycle definition for authorization and counting
For the policy’s cycle limit, each embryo transfer procedure (single or multiple embryo) counts as one IVF cycle; providers should use this definition when requesting authorizations and tracking cycle counts.
- 1 embryo transfer procedure (fresh or frozen) = 1 IVF cycle for cycle-limit purposes.
Prior authorization required for IVF cycles (CPTs and S‑codes)
Prior authorization is required for IVF cycles and related microtechnique CPTs and HCPCS case‑rate S‑codes; providers must obtain PA for the listed CPTs (e.g., 89253, 89254, 89280, 89281) and S‑codes (S4011–S4018, S4020–S4021) before services are rendered to avoid denials.
IVF cycles S‑codes require prior authorization before services
PA is required for the IVF cycle S‑codes and related case‑rate codes; obtain authorization before services are rendered to avoid denial of claims billed with these S‑codes.
- Ensure PA is in place for S4013–S4018, S4020–S4021 and related S‑codes prior to billing.
Cryopreservation/storage/thawing require iatrogenic‑infertility medical necessity
Cryopreservation, storage, and thawing codes are medically necessary only when the iatrogenic infertility criteria are met; even then, storage coverage is limited to one year (12 months) per benefit year and multiyear storage or storage over 12 months will be denied.
Diagnostic evaluation codes listed as covered (no separate PA stated)
The policy lists covered diagnostic infertility procedure and lab codes (e.g., 89300–89322, 89261, 58350, 58750); these diagnostic codes are presented as covered but the document does not state a separate prior authorization requirement for diagnostic evaluation codes in these sections.
Possible prior authorization for listed procedures (58350, 58750)
Chromotubation (CPT 58350) and tubotubal anastomosis (CPT 58750) are listed among covered diagnostic/surgical procedures; prior authorization may be required for surgical procedures per payer policy, so verify PA requirements before performing these procedures.
Prior authorization — listed diagnostic codes (diagnostics covered; no PA stated)
The Diagnostic Evaluation sections enumerate CPT/lab codes that are covered for infertility workup (multiple semen analysis and related tests); the chunks do not state a separate prior authorization requirement for these diagnostic codes.
Procedure codes listed (no PA stated) — document and verify PA if needed
The diagnostic procedure code listings for infertility evaluation enumerate covered CPT/lab codes but do not state explicit prior authorization requirements in these chunks; providers should document and bill using the listed codes and confirm PA rules with BCBSRI when in doubt.
- Document the specific CPT/lab tests performed (e.g., semen analyses 89300–89322) when submitting claims.
- If unsure about PA for a diagnostic procedure, verify with BCBSRI prior to performing the service.
Three consecutive AI cycles may be required as an eligibility step
Coverage may require three consecutive AI cycles (ICI or IUI) performed by a qualified specialist as an alternative pathway to meet eligibility prior to other services; document the AI cycle history when requesting further services.
- Three consecutive AI (ICI or IUI) cycles performed by a qualified specialist can satisfy eligibility as an alternative to duration criteria.
- Costs for the three AI cycles (medications, professional, facility) are covered; home AI is not covered.
AI/IUI medically necessary when AFAB eligibility criteria met
Artificial insemination (ICI/IUI) is medically necessary when the AFAB member meets the Eligibility Criteria for infertility; document that eligibility criteria were met when authorizing or billing AI services.
- ICI and IUI are medically necessary treatments when AFAB eligibility criteria are satisfied.
- Document eligibility (duration or prior AI attempts or specified diagnoses) in the medical record.
Document infertility per duration or semen analysis thresholds
Documented infertility must be supported by duration criteria for AFAB members (1 year unprotected intercourse or 6 months if ≥35) or by two semen analyses for AMAB members showing the specified thresholds; providers should include these findings in requests for coverage.
- AFAB: document inability to conceive after 1 year (or 6 months if age ≥35).
- AMAB: two semen analyses documenting <10M total motile sperm (pre‑wash) or <3M (post‑wash) or ≤2% normal forms (Strict Kruger).
Documentation required for requests after >4 IVF cycles
After four IVF cycles that do not result in pregnancy and delivery, the requesting physician must provide documentation of (1) number and type of prior IVF/AI attempts, (2) a revised IVF methodology with predicted success rate supported by literature, and (3) documentation that the patient has been informed of and accepts the predicted success rate; all three items (Must Have ALL) must be submitted for further transfer approval.
- Provide detailed past IVF/AI attempt history (number/type).
- Provide revised treatment plan and literature‑supported predicted success rate.
- Provide documented patient counseling and written acceptance of predicted success rate.
Documentation and billing for donor gametes; agency/transport fees not covered
When donor eggs or sperm are used, implantation and procurement services are covered and should be submitted to BCBSRI for reimbursement; however, fees charged by egg‑donation facilitation agencies and donor transportation are not covered and may be denied.
- Implantation and procurement services billed by the treating facility/provider should be submitted to BCBSRI.
- Charges from egg donation facilitation agencies and donor transportation fees are not covered.
Member‑submitted donor reimbursement requires BCBSRI form
If a member was billed directly for donor egg or sperm, the member must use the BCBSRI Donor Egg and Sperm Reimbursement Form when submitting a claim for reimbursement.
- Use the BCBSRI Donor Egg & Sperm Reimbursement Form for member‑submitted donor reimbursement claims (form linked in policy).
Document IVF services (visits, drugs, labs, procedures) as part of the cycle
Services included within an IVF procedure (office visits, medications, labs/pathology, surgical procedures) occur as part of the IVF cycle and should be documented as such when submitting prior authorization requests and claims.
- Document that office visits, drugs, labs, pathology, and surgical procedures were provided as part of an IVF cycle when requesting PA or submitting claims.
- Include associated microtechnique CPTs when seeking authorization for IVF cycle case rates.
Procedure coordination and documentation for TESA/TESE
TESA and TESE procedural coordination (timing with egg retrieval, anesthesia settings, and cryopreservation) should be documented and coordinated with the IVF/ICSI plan when these sperm retrieval procedures are performed.
- Document coordination of TESA/TESE with egg retrieval and any cryopreservation performed.
- Include procedural details (anesthesia, local vs sedation) in the record for authorization/claims.
Submit PA for complete/frozen/incomplete IVF case‑rate codes and microtechnique CPTs
Providers must submit prior authorization for complete, frozen, and incomplete IVF cycle case rates and associated microtechnique CPTs as listed in the policy; PA is required for these case‑rate and microtechnique codes.
PA required for listed HCPCS S‑codes and CPT 89280/89281
Prior authorization is required for the IVF cycle case‑rate HCPCS S‑codes (S4011–S4021 series) and CPT codes 89280 and 89281; providers must include these codes on PA requests and ensure authorization is in place before performing services.
Use S‑codes in claims and PA requests for infertility/IVF services
BCBSRI participating facilities primarily use S‑codes when reporting infertility/IVF services; providers should document and bill with the appropriate S‑code(s) listed in the policy when submitting claims and prior authorization requests.
- Use S‑codes (e.g., S4013–S4021) for reporting infertility/IVF services where applicable.
- Ensure PA and documentation reference the same S‑codes used on claims.
Iatrogenic‑infertility requirement for cryopreservation/storage/thawing coverage
Cryopreservation, storage and thawing codes are covered only when the member meets the iatrogenic infertility medical necessity criteria; otherwise these codes are not covered and claims will be denied.
Document specific semen analysis/sperm tests by CPT when submitting claims
The policy provides a list of covered diagnostic procedure and semen analysis CPT/lab codes; providers should document which specific semen analysis or sperm test was performed using the listed CPT/lab code when submitting claims or clinical documentation.
MESA/TESE excluded when chance of live birth is <5%
MESA and TESE are not covered when there is less than a 5% chance of live birth; providers should not submit claims for MESA/TESE when predicted live‑birth probability is <5% as these will be denied.
- MESA and TESE coverage excluded if <5% chance of live birth.
- Assess and document predicted live‑birth probability before requesting PA or submitting claims for MESA/TESE.
Sterilization‑related review and administrative denial risk
Requests for infertility services for members with a prior sterilization procedure will be reviewed by a clinician; if the contractual exclusion applies, the request will be administratively denied—ensure documentation demonstrates sterilization is unrelated to current infertility if seeking coverage.
- Clinician review required for prior sterilization cases.
- Provide documentation demonstrating prior sterilization is unrelated to current inability to conceive if applicable.
Egg donation facilitation agency charges not covered — bill clinical services to BCBSRI
Charges from egg donation facilitation agencies (including fees for finding a donor and donor transportation) are not covered and may be denied; once a donor is identified, services related to egg retrieval and implantation performed by the participating facility/provider should be submitted to BCBSRI for reimbursement.
- Egg donation facilitation agency fees and donor transportation costs are not covered.
- Bill implantation and retrieval services to BCBSRI via the performing facility/provider after donor is identified.
Surrogate‑related services excluded when surrogate is not plan member
All services related to surrogate parents are excluded from coverage when the surrogate is not a plan member; do not submit claims for surrogate‑related services for non‑member surrogates.
- Surrogate‑related services are excluded if the surrogate is not a member of this plan.
- Reciprocal IVF (where member is recipient) is distinct and potentially covered when eligibility criteria are met.
Claims for listed IVF CPT/S‑codes may be denied without PA
Claims for listed IVF‑related CPT and S‑codes may be denied if prior authorization is not obtained; ensure PA is obtained for the enumerated IVF CPTs and HCPCS S‑codes before services are performed to avoid denials.
Storage beyond 12 months per benefit year is not covered
Providers submitting claims for storage beyond one year (12 months) per benefit year should expect denial; multiyear storage or storage over 12 months is not covered even when iatrogenic infertility criteria are met.
- Storage coverage is limited to 12 months per benefit year; multiyear storage claims will be denied.
- Plan for annual storage billing within benefit year limits.
Diagnostic evaluation claims risk denial if billed with non‑covered codes or lacking documentation
Diagnostic infertility evaluation claims may be denied if billed with non‑covered codes or without supporting medical necessity documentation; ensure correct covered CPT/lab codes and documentation are included on claims.
Terms and Definitions
Background and Policy Scope
Background: This policy addresses assisted reproductive technologies including artificial insemination (IUI/ICI) and in vitro fertilization (IVF), plus related services such as donor gamete procurement, sperm/egg retrieval, and cryopreservation when indicated. It clarifies eligibility and medical necessity distinctions and notes that coverage details may vary by contract and product type.
Policy Revision History
Policy text revision effective date recorded as 2026-04-01 per document header noting text revision effective date.
Prior text revision effective date noted in coding section as Text Revised Effective 4/1/2025 for S‑code listings for IVF cycle case rates.
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