ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E0A includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into bone marrow. These ICD-10-PCS codes are used for inpatient documentation when clinicians administer substances directly into the bone marrow for treatment, diagnosis, or prophylaxis. Accurate coding within the ICD-10-PCS 3E0A group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Bone Marrow Introduction Procedure Overview

Procedures in this group involve the introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances directly into the bone marrow. These procedures target the physiological systems and anatomical regions associated with bone marrow access and administration. Accurate coding ensures inpatient records reflect the specific introduction procedure performed and supports correct case mix assignment and payment. Precise selection of ICD-10-PCS codes reduces coding ambiguity and helps align clinical documentation with reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
A	Body Part	Bone Marrow

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ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

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Bone Marrow Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
A	Body Part	Bone Marrow

When to Use

Use a code from this group when a substance is intentionally introduced into the bone marrow during an inpatient encounter. These codes apply when documentation specifies administration into the bone marrow as the route of delivery.

ICD-10-PCS Codes

3 rows

ICD-10-PCS Code	Description
3E0A305	Introduction of Other Antineoplastic into Bone Marrow, Percutaneous Approach
3E0A30M	Introduction of Antineoplastic, Monoclonal Antibody, into Bone Marrow, Percutaneous Approach
3E0A3GC	Introduction of Other Therapeutic Substance into Bone Marrow, Percutaneous Approach

Typical Clinical Scenarios

An adult oncology patient admitted for inpatient chemotherapy administration develops poor peripheral venous access and requires direct delivery of a monoclonal antibody antineoplastic agent into the bone marrow to ensure therapeutic drug distribution. The procedure is performed percutaneously under imaging guidance to introduce the specified monoclonal antibody into the marrow space as documented in the operative note. Coding reflects introduction of an antineoplastic monoclonal antibody via a percutaneous approach into bone marrow. Typical codes: 3E0A30M
A hospitalized patient with metastatic malignancy and symptomatic tumor burden in marrow has urgent initiation of a non-monoclonal antineoplastic agent when central venous access is not feasible; clinicians perform a percutaneous marrow infusion of an antineoplastic drug to achieve rapid local and systemic effect. The intervention is documented as introduction of an antineoplastic agent into the bone marrow during the inpatient stay for acute symptom control and oncologic therapy. Typical codes: 3E0A305
A patient with refractory osteomyelitis of the marrow space admitted for complex infection management undergoes a percutaneous introduction of an antimicrobial therapeutic substance directly into the bone marrow after systemic therapy alone was insufficient. The clinical note specifies administration of a non-antineoplastic therapeutic agent into the bone marrow to target the persistent infection. Typical codes: 3E0A3GC

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

3 rows

ICD-10-PCS Code	Description
3E0A305	Introduction of Other Antineoplastic into Bone Marrow, Percutaneous Approach
3E0A30M	Introduction of Antineoplastic, Monoclonal Antibody, into Bone Marrow, Percutaneous Approach
3E0A3GC	Introduction of Other Therapeutic Substance into Bone Marrow, Percutaneous Approach

Typical Clinical Scenarios

An adult oncology patient admitted for inpatient chemotherapy administration develops poor peripheral venous access and requires direct delivery of a monoclonal antibody antineoplastic agent into the bone marrow to ensure therapeutic drug distribution. The procedure is performed percutaneously under imaging guidance to introduce the specified monoclonal antibody into the marrow space as documented in the operative note. Coding reflects introduction of an antineoplastic monoclonal antibody via a percutaneous approach into bone marrow. Typical codes: 3E0A30M
A hospitalized patient with metastatic malignancy and symptomatic tumor burden in marrow has urgent initiation of a non-monoclonal antineoplastic agent when central venous access is not feasible; clinicians perform a percutaneous marrow infusion of an antineoplastic drug to achieve rapid local and systemic effect. The intervention is documented as introduction of an antineoplastic agent into the bone marrow during the inpatient stay for acute symptom control and oncologic therapy. Typical codes: 3E0A305
A patient with refractory osteomyelitis of the marrow space admitted for complex infection management undergoes a percutaneous introduction of an antimicrobial therapeutic substance directly into the bone marrow after systemic therapy alone was insufficient. The clinical note specifies administration of a non-antineoplastic therapeutic agent into the bone marrow to target the persistent infection. Typical codes: 3E0A3GC

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview policy alerts

Bone Marrow Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview policy alerts

Bone Marrow Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview policy alerts

Bone Marrow Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview policy alerts

Bone Marrow Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in the ICD-10-PCS code group 3E0A?

What is the clinical purpose of procedures coded in 3E0A?

What are the ICD-10-PCS code attributes for this procedure group?

How does accurate coding in the 3E0A group affect inpatient documentation and reimbursement?

Are there related DRGs listed for the 3E0A code group?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in the ICD-10-PCS code group 3E0A?

What is the clinical purpose of procedures coded in 3E0A?

What are the ICD-10-PCS code attributes for this procedure group?

How does accurate coding in the 3E0A group affect inpatient documentation and reimbursement?

Are there related DRGs listed for the 3E0A code group?

References