ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E05 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into peripheral arteries. These ICD-10-PCS codes are used for inpatient documentation when a clinician administers substances directly into a peripheral artery for treatment, diagnostics, or physiological support. Accurate coding within the ICD-10-PCS 3E05 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Peripheral Artery Introduction Procedure Overview

Procedures in this group involve introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into peripheral arteries. They target the physiological systems and anatomical regions associated with peripheral arterial vasculature and are coded in the Administration section of ICD-10-PCS. Accurate coding ensures the inpatient record reflects the specific arterial introduction performed and supports appropriate reimbursement and case mix assignment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
5	Body Part	Peripheral Artery

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ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

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Peripheral Artery Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
5	Body Part	Peripheral Artery

When to Use

Use a code from this group when a substance is intentionally introduced into a peripheral artery for therapeutic, diagnostic, nutritional, physiological, or prophylactic purposes during an inpatient encounter. Do not use these codes for administrations into non-arterial sites or for blood and blood product transfusions.

ICD-10-PCS Codes

56 rows

ICD-10-PCS Code	Description
3E05002	Introduction of High-dose Interleukin-2 into Peripheral Artery, Open Approach
3E05003	Introduction of Low-dose Interleukin-2 into Peripheral Artery, Open Approach
3E05005	Introduction of Other Antineoplastic into Peripheral Artery, Open Approach
3E0500M	Introduction of Antineoplastic, Monoclonal Antibody, into Peripheral Artery, Open Approach
3E0500P	Introduction of Clofarabine into Peripheral Artery, Open Approach
3E05016	Introduction of Recombinant Human-activated Protein C into Peripheral Artery, Open
3E05017	Introduction of Other Thrombolytic into Peripheral Artery, Open Approach
3E05028	Introduction of Oxazolidinones into Peripheral Artery, Open Approach
3E05029	Introduction of Other Anti-infective into Peripheral Artery, Open Approach
3E0503Z	Introduction of Anti-inflammatory into Peripheral Artery, Open Approach

Showing 1–10 of 56

DRG Codes

3 rows

DRG Code	Description
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC

Typical Clinical Scenarios

An adult inpatient with hepatocellular carcinoma is admitted for targeted intra-arterial chemotherapy delivered directly into a peripheral arterial access to treat a limb metastasis not amenable to systemic therapy. The interventional team gains arterial access and introduces an antineoplastic agent into a peripheral artery to provide high local drug concentration while minimizing systemic exposure. The procedure is planned and performed via a percutaneous arterial puncture under imaging guidance. Typical codes: 3E05305, 3E0530M
A patient presents emergently with acute limb-threatening soft tissue sarcoma hemorrhage where local control is needed; after stabilization the team performs percutaneous arterial access and administers a destructive agent into a peripheral artery supplying the tumor to achieve rapid tumor devascularization. This urgent inpatient procedure is intended to arrest bleeding and reduce tumor perfusion as a temporizing measure prior to definitive oncologic management. Typical codes: 3E053HZ, 3E053TZ
A hospitalized patient previously treated with systemic immunotherapy develops progressive, localized recurrent tumor in a limb; the oncology team elects to deliver a monoclonal antibody directly into a peripheral artery to maximize tumor delivery after prior systemic therapy proved insufficient. The patient undergoes an open surgical arterial exposure and introduction of the selected antineoplastic monoclonal antibody into the peripheral artery during the inpatient admission. Typical codes: 3E05005, 3E0500M

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

56 rows

ICD-10-PCS Code	Description
3E05002	Introduction of High-dose Interleukin-2 into Peripheral Artery, Open Approach
3E05003	Introduction of Low-dose Interleukin-2 into Peripheral Artery, Open Approach
3E05005	Introduction of Other Antineoplastic into Peripheral Artery, Open Approach
3E0500M	Introduction of Antineoplastic, Monoclonal Antibody, into Peripheral Artery, Open Approach
3E0500P	Introduction of Clofarabine into Peripheral Artery, Open Approach
3E05016	Introduction of Recombinant Human-activated Protein C into Peripheral Artery, Open
3E05017	Introduction of Other Thrombolytic into Peripheral Artery, Open Approach
3E05028	Introduction of Oxazolidinones into Peripheral Artery, Open Approach
3E05029	Introduction of Other Anti-infective into Peripheral Artery, Open Approach
3E0503Z	Introduction of Anti-inflammatory into Peripheral Artery, Open Approach

Showing 1–10 of 56

DRG Codes

3 rows

DRG Code	Description
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC

Typical Clinical Scenarios

An adult inpatient with hepatocellular carcinoma is admitted for targeted intra-arterial chemotherapy delivered directly into a peripheral arterial access to treat a limb metastasis not amenable to systemic therapy. The interventional team gains arterial access and introduces an antineoplastic agent into a peripheral artery to provide high local drug concentration while minimizing systemic exposure. The procedure is planned and performed via a percutaneous arterial puncture under imaging guidance. Typical codes: 3E05305, 3E0530M
A patient presents emergently with acute limb-threatening soft tissue sarcoma hemorrhage where local control is needed; after stabilization the team performs percutaneous arterial access and administers a destructive agent into a peripheral artery supplying the tumor to achieve rapid tumor devascularization. This urgent inpatient procedure is intended to arrest bleeding and reduce tumor perfusion as a temporizing measure prior to definitive oncologic management. Typical codes: 3E053HZ, 3E053TZ
A hospitalized patient previously treated with systemic immunotherapy develops progressive, localized recurrent tumor in a limb; the oncology team elects to deliver a monoclonal antibody directly into a peripheral artery to maximize tumor delivery after prior systemic therapy proved insufficient. The patient undergoes an open surgical arterial exposure and introduction of the selected antineoplastic monoclonal antibody into the peripheral artery during the inpatient admission. Typical codes: 3E05005, 3E0500M

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

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Peripheral Artery Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview policy alerts

Peripheral Artery Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview policy alerts

Peripheral Artery Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview policy alerts

Peripheral Artery Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E05?

What section, body system, and operation describe the 3E05 code group?

How does approach type affect codes in the 3E05 group?

Which substances are represented within the 3E05 code listings?

What related DRGs are associated with codes in the 3E05 group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E05?

What section, body system, and operation describe the 3E05 code group?

How does approach type affect codes in the 3E05 group?

Which substances are represented within the 3E05 code listings?

What related DRGs are associated with codes in the 3E05 group?

References