ICD-10-PCS Code For Muscle: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E02 includes procedures performed to introduce substances into muscle. These ICD-10-PCS codes are used for inpatient documentation when a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance is delivered into muscle tissue. Accurate coding within the ICD-10-PCS 3E02 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Muscle Introduction Procedure Overview

Procedures in this group involve the introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances directly into muscle tissue. These procedures target the physiological systems and anatomical regions associated with musculature and are coded in the Administration section of ICD-10-PCS. Accurate coding ensures inpatient records reflect the specific route and body part of administration, which affects clinical documentation and reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
2	Body Part	Muscle

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ICD-10-PCS Code For Muscle: Procedure Code Group Overview

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Muscle Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
2	Body Part	Muscle

When to Use

Use a code from this group when a substance is intentionally introduced directly into muscle for treatment, diagnosis, nourishment, physiological support, or prophylaxis. These codes apply when the route of administration and body part documented specify muscle as the anatomical target.

ICD-10-PCS Codes

15 rows

ICD-10-PCS Code	Description
3E02305	Introduction of Other Antineoplastic into Muscle, Percutaneous Approach
3E0230M	Introduction of Antineoplastic, Monoclonal Antibody, into Muscle, Percutaneous Approach
3E02328	Introduction of Oxazolidinones into Muscle, Percutaneous Approach
3E02329	Introduction of Other Anti-infective into Muscle, Percutaneous Approach
3E0233Z	Introduction of Anti-inflammatory into Muscle, Percutaneous Approach
3E02340	Introduction of Influenza Vaccine into Muscle, Percutaneous Approach
3E0234Z	Introduction of Serum, Toxoid and Vaccine into Muscle, Percutaneous Approach
3E0236Z	Introduction of Nutritional Substance into Muscle, Percutaneous Approach
3E0237Z	Introduction of Electrolytic and Water Balance Substance into Muscle, Percutaneous Approach
3E023BZ	Introduction of Anesthetic Agent into Muscle, Percutaneous Approach

Showing 1–10 of 15

Typical Clinical Scenarios

An elderly patient admitted for inpatient observation after sudden onset of high fever and suspected severe bacterial cellulitis of the thigh unresponsive to oral therapy; intravenous access is limited and the team administers intramuscular antibiotics directly into the affected muscle to achieve rapid local and systemic levels. Typical codes: 3E02329
A middle-aged oncology patient hospitalized for planned chemotherapy support who requires intramuscular administration of a monoclonal antibody as part of a targeted antineoplastic regimen delivered percutaneously into skeletal muscle under scheduled inpatient infusion protocols. Typical codes: 3E0230M, 3E02305
A hospitalized post-operative patient develops severe, localized muscle pain with documented inflammatory reaction at the surgical site and is given percutaneous intramuscular injection of an anti-inflammatory agent for symptom control and to reduce tissue inflammation after other routes are contraindicated. Typical codes: 3E0233Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

15 rows

ICD-10-PCS Code	Description
3E02305	Introduction of Other Antineoplastic into Muscle, Percutaneous Approach
3E0230M	Introduction of Antineoplastic, Monoclonal Antibody, into Muscle, Percutaneous Approach
3E02328	Introduction of Oxazolidinones into Muscle, Percutaneous Approach
3E02329	Introduction of Other Anti-infective into Muscle, Percutaneous Approach
3E0233Z	Introduction of Anti-inflammatory into Muscle, Percutaneous Approach
3E02340	Introduction of Influenza Vaccine into Muscle, Percutaneous Approach
3E0234Z	Introduction of Serum, Toxoid and Vaccine into Muscle, Percutaneous Approach
3E0236Z	Introduction of Nutritional Substance into Muscle, Percutaneous Approach
3E0237Z	Introduction of Electrolytic and Water Balance Substance into Muscle, Percutaneous Approach
3E023BZ	Introduction of Anesthetic Agent into Muscle, Percutaneous Approach

Showing 1–10 of 15

Typical Clinical Scenarios

An elderly patient admitted for inpatient observation after sudden onset of high fever and suspected severe bacterial cellulitis of the thigh unresponsive to oral therapy; intravenous access is limited and the team administers intramuscular antibiotics directly into the affected muscle to achieve rapid local and systemic levels. Typical codes: 3E02329
A middle-aged oncology patient hospitalized for planned chemotherapy support who requires intramuscular administration of a monoclonal antibody as part of a targeted antineoplastic regimen delivered percutaneously into skeletal muscle under scheduled inpatient infusion protocols. Typical codes: 3E0230M, 3E02305
A hospitalized post-operative patient develops severe, localized muscle pain with documented inflammatory reaction at the surgical site and is given percutaneous intramuscular injection of an anti-inflammatory agent for symptom control and to reduce tissue inflammation after other routes are contraindicated. Typical codes: 3E0233Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Muscle: Procedure Code Group Overview policy alerts

Muscle Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Muscle: Procedure Code Group Overview policy alerts

Muscle Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Muscle: Procedure Code Group Overview policy alerts

Muscle Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Muscle: Procedure Code Group Overview policy alerts

Muscle Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E02?

What is the ICD-10-PCS section and body system for these muscle introduction procedures?

How are individual codes in the 3E02 group distinguished?

Why is accurate coding within the 3E02 group important for inpatient records?

Can you list examples of codes for anti-infective and vaccine introductions into muscle?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E02?

What is the ICD-10-PCS section and body system for these muscle introduction procedures?

How are individual codes in the 3E02 group distinguished?

Why is accurate coding within the 3E02 group important for inpatient records?

Can you list examples of codes for anti-infective and vaccine introductions into muscle?

References