ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E04 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the central vein. These ICD-10-PCS codes are used for inpatient documentation when a substance is administered directly into a central venous access for clinical management, nutrition, diagnostics, or prophylaxis. Accurate coding within the ICD-10-PCS 3E04 group is essential for proper inpatient reimbursement, as it captures the procedure performed and documents the specific route of administration that affects case mix and payment.

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Central Vein Introduction Procedure Overview

This procedure group includes introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the central vein. Procedures target the physiological systems and anatomical regions related to central venous access and delivery. Accurate coding of these introduction procedures ensures inpatient records reflect the route and intent of substance administration and supports appropriate reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
4	Body Part	Central Vein

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ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

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Central Vein Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
4	Body Part	Central Vein

When to Use

Use codes from this group when a substance is intentionally introduced into a central vein during an inpatient encounter. Select the code that reflects the introduction operation, the central venous site, and the substance administered.

ICD-10-PCS Codes

59 rows

ICD-10-PCS Code	Description
3E04002	Introduction of High-dose Interleukin-2 into Central Vein, Open Approach
3E04003	Introduction of Low-dose Interleukin-2 into Central Vein, Open Approach
3E04005	Introduction of Other Antineoplastic into Central Vein, Open Approach
3E0400M	Introduction of Antineoplastic, Monoclonal Antibody, into Central Vein, Open Approach
3E0400P	Introduction of Clofarabine into Central Vein, Open Approach
3E04016	Introduction of Recombinant Human-activated Protein C into Central Vein, Open
3E04017	Introduction of Other Thrombolytic into Central Vein, Open Approach
3E04028	Introduction of Oxazolidinones into Central Vein, Open Approach
3E04029	Introduction of Other Anti-infective into Central Vein, Open Approach
3E0403Z	Introduction of Anti-inflammatory into Central Vein, Open Approach

Showing 1–10 of 59

DRG Codes

7 rows

DRG Code	Description
037	Extracranial Procedures with MCC
038	Extracranial Procedures with CC
039	Extracranial Procedures without CC/MCC
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC
263	Vein Ligation and Stripping

Typical Clinical Scenarios

A critically ill adult in the intensive care unit with septic shock requires central venous administration of broad-spectrum intravenous antibiotics and vasopressors through a newly placed central line to ensure reliable delivery and hemodynamic support. The procedure introduces anti-infective and vasoactive agents directly into the central vein using a percutaneous central venous catheter. Coding reflects percutaneous introduction of anti-infective or vasopressor substances into the central vein. Typical codes: 3E04329, 3E043XZ
An oncology patient admitted for inpatient chemotherapy receives planned administration of a monoclonal antibody regimen through an indwelling central venous catheter placed via an open surgical tunneled approach for long-term therapy. The scheduled inpatient procedure documents introduction of an antineoplastic, monoclonal antibody into the central vein via an open approach. Typical codes: 3E0400M
A hospitalized patient with a malfunctioning peripherally inserted central catheter (PICC) develops recurrent line infections and is taken to the operating room for removal of the infected line and open replacement with a new central venous catheter, with intraoperative administration of prophylactic serum/toxoid vaccine prior to immunosuppressive therapy. The coding should capture the open approach introduction of a serum, toxoid or vaccine into the central vein performed during the operative revision. Typical codes: 3E0404Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

59 rows

ICD-10-PCS Code	Description
3E04002	Introduction of High-dose Interleukin-2 into Central Vein, Open Approach
3E04003	Introduction of Low-dose Interleukin-2 into Central Vein, Open Approach
3E04005	Introduction of Other Antineoplastic into Central Vein, Open Approach
3E0400M	Introduction of Antineoplastic, Monoclonal Antibody, into Central Vein, Open Approach
3E0400P	Introduction of Clofarabine into Central Vein, Open Approach
3E04016	Introduction of Recombinant Human-activated Protein C into Central Vein, Open
3E04017	Introduction of Other Thrombolytic into Central Vein, Open Approach
3E04028	Introduction of Oxazolidinones into Central Vein, Open Approach
3E04029	Introduction of Other Anti-infective into Central Vein, Open Approach
3E0403Z	Introduction of Anti-inflammatory into Central Vein, Open Approach

Showing 1–10 of 59

DRG Codes

7 rows

DRG Code	Description
037	Extracranial Procedures with MCC
038	Extracranial Procedures with CC
039	Extracranial Procedures without CC/MCC
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC
263	Vein Ligation and Stripping

Typical Clinical Scenarios

A critically ill adult in the intensive care unit with septic shock requires central venous administration of broad-spectrum intravenous antibiotics and vasopressors through a newly placed central line to ensure reliable delivery and hemodynamic support. The procedure introduces anti-infective and vasoactive agents directly into the central vein using a percutaneous central venous catheter. Coding reflects percutaneous introduction of anti-infective or vasopressor substances into the central vein. Typical codes: 3E04329, 3E043XZ
An oncology patient admitted for inpatient chemotherapy receives planned administration of a monoclonal antibody regimen through an indwelling central venous catheter placed via an open surgical tunneled approach for long-term therapy. The scheduled inpatient procedure documents introduction of an antineoplastic, monoclonal antibody into the central vein via an open approach. Typical codes: 3E0400M
A hospitalized patient with a malfunctioning peripherally inserted central catheter (PICC) develops recurrent line infections and is taken to the operating room for removal of the infected line and open replacement with a new central venous catheter, with intraoperative administration of prophylactic serum/toxoid vaccine prior to immunosuppressive therapy. The coding should capture the open approach introduction of a serum, toxoid or vaccine into the central vein performed during the operative revision. Typical codes: 3E0404Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Central Vein Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Central Vein Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Central Vein Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Central Vein Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation describe central vein introduction procedures?

How does accurate coding in the 3E04 code group affect inpatient records?

What code examples indicate different approaches for introducing substances into the central vein?

Which related DRGs are associated with procedures in this code group?

What types of substances are represented in the 3E04 ICD-10-PCS codes?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation describe central vein introduction procedures?

How does accurate coding in the 3E04 code group affect inpatient records?

What code examples indicate different approaches for introducing substances into the central vein?

Which related DRGs are associated with procedures in this code group?

What types of substances are represented in the 3E04 ICD-10-PCS codes?

References