ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E01 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances in the subcutaneous tissue. These ICD-10-PCS codes are used for inpatient documentation when a substance is administered into the subcutaneous tissue for treatment, diagnosis, nutrition, physiologic effect, or prophylaxis. Accurate coding within the ICD-10-PCS 3E01 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Subcutaneous Tissue Introduction Procedure Overview

Procedures in this group involve introducing therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the subcutaneous tissue. They target the physiological systems and anatomical region of the subcutaneous tissue and are coded in the Administration section of ICD-10-PCS. Accurate coding ensures the inpatient record reflects the administration route and substance introduced, which affects case mix and payment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
1	Body Part	Subcutaneous Tissue

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ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

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Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
1	Body Part	Subcutaneous Tissue

When to Use

Use a code from this group when a substance is intentionally introduced into the subcutaneous tissue as the primary procedure during an inpatient encounter. Codes in this group apply when the route of administration into the subcutaneous tissue is the defining characteristic of the procedure performed.

ICD-10-PCS Codes

19 rows

ICD-10-PCS Code	Description
3E0102A	Introduction of Anti-Infective Envelope into Subcutaneous Tissue, Open Approach
3E01305	Introduction of Other Antineoplastic into Subcutaneous Tissue, Percutaneous Approach
3E0130M	Introduction of Antineoplastic, Monoclonal Antibody, into Subcutaneous Tissue, Percutaneous Approach
3E01328	Introduction of Oxazolidinones into Subcutaneous Tissue, Percutaneous Approach
3E01329	Introduction of Other Anti-infective into Subcutaneous Tissue, Percutaneous Approach
3E0132A	Introduction of Anti-Infective Envelope into Subcutaneous Tissue, Percutaneous Approach
3E0133Z	Introduction of Anti-inflammatory into Subcutaneous Tissue, Percutaneous Approach
3E01340	Introduction of Influenza Vaccine into Subcutaneous Tissue, Percutaneous Approach
3E0134Z	Introduction of Serum, Toxoid and Vaccine into Subcutaneous Tissue, Percutaneous Approach
3E0136Z	Introduction of Nutritional Substance into Subcutaneous Tissue, Percutaneous Approach

Showing 1–10 of 19

Typical Clinical Scenarios

An elderly inpatient with poorly controlled type 1 diabetes is admitted for hyperglycemia management and transition to a basal insulin regimen. The team requires reliable subcutaneous delivery of insulin for glycemic control while adjusting doses and monitoring in the hospital. A percutaneous introduction of insulin into the subcutaneous tissue is performed to establish the therapeutic regimen. Typical codes: 3E013VG
A middle-aged patient presents to the emergency department with severe allergic reaction prophylaxis after exposure to a known allergen; inpatient observation is required due to respiratory symptoms. For rapid onset and reliable absorption while under monitoring, a percutaneous subcutaneous injection of an anti-inflammatory or antihistaminic therapeutic agent is administered. The procedure is performed once during the acute inpatient stay to control the allergic process. Typical codes: 3E0133Z
A cancer patient admitted for complications of chemotherapy with recurrent local tumor seeding under the skin requires localized therapeutic delivery. The oncology team performs percutaneous subcutaneous administration of a monoclonal antibody antineoplastic agent to target residual subcutaneous tumor deposits as part of inpatient treatment and symptom control. This targeted introduction is performed during the admission to address progression not controlled by systemic therapy alone. Typical codes: 3E0130M

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

19 rows

ICD-10-PCS Code	Description
3E0102A	Introduction of Anti-Infective Envelope into Subcutaneous Tissue, Open Approach
3E01305	Introduction of Other Antineoplastic into Subcutaneous Tissue, Percutaneous Approach
3E0130M	Introduction of Antineoplastic, Monoclonal Antibody, into Subcutaneous Tissue, Percutaneous Approach
3E01328	Introduction of Oxazolidinones into Subcutaneous Tissue, Percutaneous Approach
3E01329	Introduction of Other Anti-infective into Subcutaneous Tissue, Percutaneous Approach
3E0132A	Introduction of Anti-Infective Envelope into Subcutaneous Tissue, Percutaneous Approach
3E0133Z	Introduction of Anti-inflammatory into Subcutaneous Tissue, Percutaneous Approach
3E01340	Introduction of Influenza Vaccine into Subcutaneous Tissue, Percutaneous Approach
3E0134Z	Introduction of Serum, Toxoid and Vaccine into Subcutaneous Tissue, Percutaneous Approach
3E0136Z	Introduction of Nutritional Substance into Subcutaneous Tissue, Percutaneous Approach

Showing 1–10 of 19

Typical Clinical Scenarios

An elderly inpatient with poorly controlled type 1 diabetes is admitted for hyperglycemia management and transition to a basal insulin regimen. The team requires reliable subcutaneous delivery of insulin for glycemic control while adjusting doses and monitoring in the hospital. A percutaneous introduction of insulin into the subcutaneous tissue is performed to establish the therapeutic regimen. Typical codes: 3E013VG
A middle-aged patient presents to the emergency department with severe allergic reaction prophylaxis after exposure to a known allergen; inpatient observation is required due to respiratory symptoms. For rapid onset and reliable absorption while under monitoring, a percutaneous subcutaneous injection of an anti-inflammatory or antihistaminic therapeutic agent is administered. The procedure is performed once during the acute inpatient stay to control the allergic process. Typical codes: 3E0133Z
A cancer patient admitted for complications of chemotherapy with recurrent local tumor seeding under the skin requires localized therapeutic delivery. The oncology team performs percutaneous subcutaneous administration of a monoclonal antibody antineoplastic agent to target residual subcutaneous tumor deposits as part of inpatient treatment and symptom control. This targeted introduction is performed during the admission to address progression not controlled by systemic therapy alone. Typical codes: 3E0130M

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

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Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview policy alerts

Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview policy alerts

Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview policy alerts

Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation describe procedures in the 3E01 code group?

What substances are excluded from the 3E01 subcutaneous introduction codes?

How does accurate coding within the ICD-10-PCS 3E01 group impact inpatient care documentation?

Can you list examples of specific ICD-10-PCS codes in the 3E01 group and what they introduce?

What body part and approaches are specified for codes in the 3E01 group?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation describe procedures in the 3E01 code group?

What substances are excluded from the 3E01 subcutaneous introduction codes?

How does accurate coding within the ICD-10-PCS 3E01 group impact inpatient care documentation?

Can you list examples of specific ICD-10-PCS codes in the 3E01 group and what they introduce?

What body part and approaches are specified for codes in the 3E01 group?

References