ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E00 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances onto or into the skin and mucous membranes. These ICD-10-PCS codes are used for inpatient documentation when substances are applied to or instilled on skin or mucous membrane surfaces as part of treatment, diagnosis, or prophylaxis. Accurate coding within the ICD-10-PCS 3E00 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

Customize your policy alerts

Sign up for ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Skin And Mucous Membranes Introduction Procedure Overview

This procedure group includes introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into or onto the skin and mucous membranes. Procedures target the physiological systems and anatomical regions associated with skin and mucous membranes and involve applying or instilling substances rather than surgical alteration. Accurate ICD-10-PCS coding matters for inpatient reimbursement because it documents the specific administration procedure performed and supports appropriate case mix assignment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
0	Body Part	Skin and Mucous Membranes

Explore openpayer tools

View all tools

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

Customize your policy alerts

Sign up for ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Skin And Mucous Membranes Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
0	Body Part	Skin and Mucous Membranes

When to Use

Use a code from this group when a substance other than blood or blood products is applied to or instilled on a patient’s skin or mucous membranes during an inpatient encounter. Select the code that matches the substance introduced and the precise anatomical site to reflect the procedure performed.

ICD-10-PCS Codes

12 rows

ICD-10-PCS Code	Description
3E00X05	Introduction of Other Antineoplastic into Skin and Mucous Membranes, External Approach
3E00X0M	Introduction of Antineoplastic, Monoclonal Antibody, into Skin and Mucous Membranes, External Approach
3E00X28	Introduction of Oxazolidinones into Skin and Mucous Membranes, External Approach
3E00X29	Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach
3E00X3Z	Introduction of Anti-inflammatory into Skin and Mucous Membranes, External Approach
3E00X4Z	Introduction of Serum, Toxoid and Vaccine into Skin and Mucous Membranes, External Approach
3E00XBZ	Introduction of Anesthetic Agent into Skin and Mucous Membranes, External Approach
3E00XGC	Introduction of Other Therapeutic Substance into Skin and Mucous Membranes, External Approach
3E00XKZ	Introduction of Other Diagnostic Substance into Skin and Mucous Membranes, External Approach
3E00XMZ	Introduction of Pigment into Skin and Mucous Membranes, External Approach

Showing 1–10 of 12

Typical Clinical Scenarios

An elderly inpatient develops a painful, well-demarcated area of skin necrosis after starting topical chemotherapy for cutaneous malignancy; the wound care team applies a topical anti-inflammatory agent to the affected skin surfaces to reduce inflammation and facilitate healing as part of acute inpatient wound management. The introduction is performed onto external skin surfaces and documented as a therapeutic, non-surgical administration. Typical codes: 3E00X3Z
A patient admitted for symptomatic allergic contact dermatitis with widespread mucosal and perioral involvement is treated with topical anesthetic to the oral mucosa and perioral skin to allow painful lesion debridement and symptomatic relief during a planned inpatient dermatology procedure. The application targets skin and mucous membrane surfaces and is recorded as an administered topical anesthetic. Typical codes: 3E00XBZ
A hospitalized immunocompromised patient develops a localized cutaneous bacterial infection that does not respond to systemic therapy; the dermatology consult applies a topical anti-infective agent (an oxazolidinone-class preparation) directly to the infected skin and mucous membrane areas to attempt targeted therapy and limit progression. This represents escalation of therapy for a complication in the inpatient setting. Typical codes: 3E00X28, 3E00X29

Related Codes

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-PCS Codes

12 rows

ICD-10-PCS Code	Description
3E00X05	Introduction of Other Antineoplastic into Skin and Mucous Membranes, External Approach
3E00X0M	Introduction of Antineoplastic, Monoclonal Antibody, into Skin and Mucous Membranes, External Approach
3E00X28	Introduction of Oxazolidinones into Skin and Mucous Membranes, External Approach
3E00X29	Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach
3E00X3Z	Introduction of Anti-inflammatory into Skin and Mucous Membranes, External Approach
3E00X4Z	Introduction of Serum, Toxoid and Vaccine into Skin and Mucous Membranes, External Approach
3E00XBZ	Introduction of Anesthetic Agent into Skin and Mucous Membranes, External Approach
3E00XGC	Introduction of Other Therapeutic Substance into Skin and Mucous Membranes, External Approach
3E00XKZ	Introduction of Other Diagnostic Substance into Skin and Mucous Membranes, External Approach
3E00XMZ	Introduction of Pigment into Skin and Mucous Membranes, External Approach

Showing 1–10 of 12

Typical Clinical Scenarios

An elderly inpatient develops a painful, well-demarcated area of skin necrosis after starting topical chemotherapy for cutaneous malignancy; the wound care team applies a topical anti-inflammatory agent to the affected skin surfaces to reduce inflammation and facilitate healing as part of acute inpatient wound management. The introduction is performed onto external skin surfaces and documented as a therapeutic, non-surgical administration. Typical codes: 3E00X3Z
A patient admitted for symptomatic allergic contact dermatitis with widespread mucosal and perioral involvement is treated with topical anesthetic to the oral mucosa and perioral skin to allow painful lesion debridement and symptomatic relief during a planned inpatient dermatology procedure. The application targets skin and mucous membrane surfaces and is recorded as an administered topical anesthetic. Typical codes: 3E00XBZ
A hospitalized immunocompromised patient develops a localized cutaneous bacterial infection that does not respond to systemic therapy; the dermatology consult applies a topical anti-infective agent (an oxazolidinone-class preparation) directly to the infected skin and mucous membrane areas to attempt targeted therapy and limit progression. This represents escalation of therapy for a complication in the inpatient setting. Typical codes: 3E00X28, 3E00X29

Related Codes

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview policy alerts

Skin And Mucous Membranes Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview policy alerts

Skin And Mucous Membranes Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E00?

What is the principal operation and body system for codes in this group?

How should individual ICD-10-PCS codes from this group be presented in documentation or coding lists?

Why is accurate coding within the 3E00 group important for inpatient reimbursement?

Are there related DRGs listed for the 3E00 code group?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E00?

What is the principal operation and body system for codes in this group?

How should individual ICD-10-PCS codes from this group be presented in documentation or coding lists?

Why is accurate coding within the 3E00 group important for inpatient reimbursement?

Are there related DRGs listed for the 3E00 code group?

References