ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E06 includes procedures performed to introduce therapeutic, nutritional, physiological, or diagnostic substances into the central artery. These ICD-10-PCS codes are used for inpatient documentation when a substance is delivered directly into a central artery via catheter or other introducer for treatment, nutrition, monitoring, or diagnostic purposes. Accurate coding within the ICD-10-PCS 3E06 group is essential for proper inpatient reimbursement, as it captures the procedure performed and determines appropriate case mix and payment.

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Central Artery Introduction Procedure Overview

Procedures in ICD-10 PCS 3E06 introduce therapeutic, nutritional, physiological, or diagnostic substances into the central artery of the physiological systems and anatomical regions body system. These procedures involve percutaneous or open placement of a catheter or device into a central artery to deliver specified substances directly into the arterial circulation. Accurate coding identifies the arterial route of administration and supports appropriate inpatient reimbursement by documenting the specific introduction procedure performed.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
6	Body Part	Central Artery

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ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

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Central Artery Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
6	Body Part	Central Artery

When to Use

Use a code from this group when a substance is deliberately introduced into a central artery for therapeutic, nutritional, physiological, or diagnostic purposes. Select the code that reflects the specific introducer, approach, and substance administered to document the inpatient procedure accurately.

ICD-10-PCS Codes

56 rows

ICD-10-PCS Code	Description
3E06002	Introduction of High-dose Interleukin-2 into Central Artery, Open Approach
3E06003	Introduction of Low-dose Interleukin-2 into Central Artery, Open Approach
3E06005	Introduction of Other Antineoplastic into Central Artery, Open Approach
3E0600M	Introduction of Antineoplastic, Monoclonal Antibody, into Central Artery, Open Approach
3E0600P	Introduction of Clofarabine into Central Artery, Open Approach
3E06016	Introduction of Recombinant Human-activated Protein C into Central Artery, Open
3E06017	Introduction of Other Thrombolytic into Central Artery, Open Approach
3E06028	Introduction of Oxazolidinones into Central Artery, Open Approach
3E06029	Introduction of Other Anti-infective into Central Artery, Open Approach
3E0603Z	Introduction of Anti-inflammatory into Central Artery, Open Approach

Showing 1–10 of 56

DRG Codes

3 rows

DRG Code	Description
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC

Typical Clinical Scenarios

An adult patient is admitted for planned intra-arterial chemotherapy via catheter placed into a central arterial vessel to deliver a high-concentration antineoplastic agent directly to a hepatic tumor bed. The procedure is performed in the operating room using an open surgical approach to ensure secure catheter placement and precise drug delivery. The goal is localized tumor control while minimizing systemic exposure. Typical codes: 3E06005, 3E0600M
A critically ill patient develops severe septic shock with refractory hypotension requiring direct central arterial administration of vasopressors to achieve rapid hemodynamic support. Because peripheral access is inadequate and continuous high-dose infusion is needed, an open approach is used to place an arterial introducer into a central artery for direct delivery of the vasopressor medication. This is performed urgently during the inpatient admission to stabilize circulation. Typical codes: 3E060XZ
A hospitalized patient with malnutrition and poor enteral tolerance requires direct arterial infusion of a nutritional formulation because prior percutaneous catheter attempts thrombosed and failed. During a revision procedure, the surgical team performs an open placement of a catheter into a central artery to re-establish a reliable route for administration of concentrated nutritional substances. This revision is undertaken to restore adequate nutrient delivery while addressing prior catheter-related complications. Typical codes: 3E0606Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

56 rows

ICD-10-PCS Code	Description
3E06002	Introduction of High-dose Interleukin-2 into Central Artery, Open Approach
3E06003	Introduction of Low-dose Interleukin-2 into Central Artery, Open Approach
3E06005	Introduction of Other Antineoplastic into Central Artery, Open Approach
3E0600M	Introduction of Antineoplastic, Monoclonal Antibody, into Central Artery, Open Approach
3E0600P	Introduction of Clofarabine into Central Artery, Open Approach
3E06016	Introduction of Recombinant Human-activated Protein C into Central Artery, Open
3E06017	Introduction of Other Thrombolytic into Central Artery, Open Approach
3E06028	Introduction of Oxazolidinones into Central Artery, Open Approach
3E06029	Introduction of Other Anti-infective into Central Artery, Open Approach
3E0603Z	Introduction of Anti-inflammatory into Central Artery, Open Approach

Showing 1–10 of 56

DRG Codes

3 rows

DRG Code	Description
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC

Typical Clinical Scenarios

An adult patient is admitted for planned intra-arterial chemotherapy via catheter placed into a central arterial vessel to deliver a high-concentration antineoplastic agent directly to a hepatic tumor bed. The procedure is performed in the operating room using an open surgical approach to ensure secure catheter placement and precise drug delivery. The goal is localized tumor control while minimizing systemic exposure. Typical codes: 3E06005, 3E0600M
A critically ill patient develops severe septic shock with refractory hypotension requiring direct central arterial administration of vasopressors to achieve rapid hemodynamic support. Because peripheral access is inadequate and continuous high-dose infusion is needed, an open approach is used to place an arterial introducer into a central artery for direct delivery of the vasopressor medication. This is performed urgently during the inpatient admission to stabilize circulation. Typical codes: 3E060XZ
A hospitalized patient with malnutrition and poor enteral tolerance requires direct arterial infusion of a nutritional formulation because prior percutaneous catheter attempts thrombosed and failed. During a revision procedure, the surgical team performs an open placement of a catheter into a central artery to re-establish a reliable route for administration of concentrated nutritional substances. This revision is undertaken to restore adequate nutrient delivery while addressing prior catheter-related complications. Typical codes: 3E0606Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Artery: Procedure Code Group Overview policy alerts

Central Artery Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Artery: Procedure Code Group Overview policy alerts

Central Artery Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Artery: Procedure Code Group Overview policy alerts

Central Artery Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Artery: Procedure Code Group Overview policy alerts

Central Artery Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E06?

How does the 3E06 group differentiate approach types?

Why is accurate coding within ICD-10-PCS 3E06 important for inpatient reimbursement?

Which 3E06 codes relate specifically to nutritional or fluid balance substances?

What DRGs are associated with procedures in the 3E06 group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E06?

How does the 3E06 group differentiate approach types?

Why is accurate coding within ICD-10-PCS 3E06 important for inpatient reimbursement?

Which 3E06 codes relate specifically to nutritional or fluid balance substances?

What DRGs are associated with procedures in the 3E06 group?

References