ICD-10-PCS Code For Heart: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E08 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the heart. These ICD-10-PCS codes are used for inpatient documentation when a substance is administered directly into the heart for treatment, diagnosis, nutrition, or physiological support. Accurate coding within the ICD-10-PCS 3E08 group is essential for proper inpatient reimbursement, as it captures the procedure performed and determines appropriate case mix and payment.

Customize your policy alerts

Sign up for ICD-10-PCS Code For Heart: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Heart Introduction Procedure Overview

Procedures in this group involve the introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the heart. These procedures target the physiological systems and anatomical regions related to the heart and are coded in the Administration section of the International Classification of Diseases, Tenth Revision, Procedure Coding System. Accurate coding matters for inpatient reimbursement because it documents the specific substance administration and supports appropriate case mix assignment and payment. Precise code selection also ensures clear clinical documentation and continuity of care.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
8	Body Part	Heart

Explore openpayer tools

View all tools

ICD-10-PCS Code For Heart: Procedure Code Group Overview

Customize your policy alerts

Sign up for ICD-10-PCS Code For Heart: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Heart Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
8	Body Part	Heart

When to Use

Use a code from this group when a substance is intentionally introduced into the heart during an inpatient encounter for therapeutic, diagnostic, nutritional, physiological, or prophylactic purposes. Select the specific code based on the substance administered and the documented route and approach of introduction.

ICD-10-PCS Codes

11 rows

ICD-10-PCS Code	Description
3E08016	Introduction of Recombinant Human-activated Protein C into Heart, Open
3E08017	Introduction of Other Thrombolytic into Heart, Open Approach
3E080GC	Introduction of Other Therapeutic Substance into Heart, Open Approach
3E080KZ	Introduction of Other Diagnostic Substance into Heart, Open Approach
3E080PZ	Introduction of Platelet Inhibitor into Heart, Open Approach
3E08316	Introduction of Recombinant Human-activated Protein C into Heart, Percutaneous
3E08317	Introduction of Other Thrombolytic into Heart, Percutaneous Approach
3E083GC	Introduction of Other Therapeutic Substance into Heart, Percutaneous Approach
3E083KZ	Introduction of Other Diagnostic Substance into Heart, Percutaneous Approach
3E083PZ	Introduction of Platelet Inhibitor into Heart, Percutaneous Approach

Showing 1–10 of 11

DRG Codes

3 rows

DRG Code	Description
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC

Typical Clinical Scenarios

An adult patient is admitted with acute ST-elevation myocardial infarction complicated by a large intracardiac thrombus identified on echocardiography. During the emergent inpatient intervention, a thrombolytic agent is delivered directly into the heart via percutaneous catheter to lyse the clot and restore intracardiac flow. The procedure is performed urgently in the cath lab using a percutaneous approach to introduce the thrombolytic into the heart. Typical codes: 3E08317
A patient with chronic heart failure and recurrent microthrombi identified on imaging is admitted for a planned intracardiac therapeutic infusion to prevent further embolization. In a scheduled inpatient procedure, a therapeutic non-standard agent (other therapeutic substance) is introduced into the heart via an open surgical approach during a concurrent cardiac operation to provide targeted physiological support. The administration is elective and coordinated with the operative repair. Typical codes: 3E080GC
A patient previously treated with percutaneous intracardiac therapy develops persistent diagnostic uncertainty about intracardiac source of recurrent emboli despite prior treatment. During a subsequent inpatient procedure, a diagnostic contrast or other diagnostic substance is introduced directly into the heart via a percutaneous approach to obtain targeted imaging and sampling for clarification of the problem. This is performed to guide further management after the initial therapy. Typical codes: 3E083KZ

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-PCS Codes

11 rows

ICD-10-PCS Code	Description
3E08016	Introduction of Recombinant Human-activated Protein C into Heart, Open
3E08017	Introduction of Other Thrombolytic into Heart, Open Approach
3E080GC	Introduction of Other Therapeutic Substance into Heart, Open Approach
3E080KZ	Introduction of Other Diagnostic Substance into Heart, Open Approach
3E080PZ	Introduction of Platelet Inhibitor into Heart, Open Approach
3E08316	Introduction of Recombinant Human-activated Protein C into Heart, Percutaneous
3E08317	Introduction of Other Thrombolytic into Heart, Percutaneous Approach
3E083GC	Introduction of Other Therapeutic Substance into Heart, Percutaneous Approach
3E083KZ	Introduction of Other Diagnostic Substance into Heart, Percutaneous Approach
3E083PZ	Introduction of Platelet Inhibitor into Heart, Percutaneous Approach

Showing 1–10 of 11

DRG Codes

3 rows

DRG Code	Description
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC

Typical Clinical Scenarios

An adult patient is admitted with acute ST-elevation myocardial infarction complicated by a large intracardiac thrombus identified on echocardiography. During the emergent inpatient intervention, a thrombolytic agent is delivered directly into the heart via percutaneous catheter to lyse the clot and restore intracardiac flow. The procedure is performed urgently in the cath lab using a percutaneous approach to introduce the thrombolytic into the heart. Typical codes: 3E08317
A patient with chronic heart failure and recurrent microthrombi identified on imaging is admitted for a planned intracardiac therapeutic infusion to prevent further embolization. In a scheduled inpatient procedure, a therapeutic non-standard agent (other therapeutic substance) is introduced into the heart via an open surgical approach during a concurrent cardiac operation to provide targeted physiological support. The administration is elective and coordinated with the operative repair. Typical codes: 3E080GC
A patient previously treated with percutaneous intracardiac therapy develops persistent diagnostic uncertainty about intracardiac source of recurrent emboli despite prior treatment. During a subsequent inpatient procedure, a diagnostic contrast or other diagnostic substance is introduced directly into the heart via a percutaneous approach to obtain targeted imaging and sampling for clarification of the problem. This is performed to guide further management after the initial therapy. Typical codes: 3E083KZ

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Heart: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Heart: Procedure Code Group Overview policy alerts

Heart Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Heart: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Heart: Procedure Code Group Overview policy alerts

Heart Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Heart: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Heart: Procedure Code Group Overview policy alerts

Heart Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Heart: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Heart: Procedure Code Group Overview policy alerts

Heart Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E08?

What is the clinical focus of procedures coded in 3E08?

How does accurate coding in 3E08 affect inpatient reimbursement?

What code attributes define the 3E08 group in ICD-10-PCS?

Which DRGs are related to procedures in this group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 3E08?

What is the clinical focus of procedures coded in 3E08?

How does accurate coding in 3E08 affect inpatient reimbursement?

What code attributes define the 3E08 group in ICD-10-PCS?

Which DRGs are related to procedures in this group?

References