ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 3E03 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into peripheral veins. These ICD-10-PCS codes are used for inpatient documentation when a substance is administered directly into a peripheral venous access for treatment, nutrition, diagnostics, or prophylaxis. Accurate coding within the ICD-10-PCS 3E03 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

Customize your policy alerts

Sign up for ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Peripheral Vein Introduction Procedure Overview

Procedures in this group involve introducing therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the peripheral venous system. They target the physiological systems and anatomical regions via peripheral veins and are coded in the Administration section of ICD-10-PCS. Accurate coding ensures the inpatient record reflects the specific route and method of substance introduction, which affects case mix and reimbursement. Clear documentation of the vein used and substance introduced supports correct code selection.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
3	Body Part	Peripheral Vein

Explore openpayer tools

View all tools

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

Customize your policy alerts

Sign up for ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Peripheral Vein Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
3	Section	Administration
E	Body System	Physiological Systems and Anatomical Regions
0	Operation	Introduction
3	Body Part	Peripheral Vein

When to Use

Use a code from this group when a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance is introduced into a peripheral vein during an inpatient stay. Select the code that matches the documented peripheral venous access and the substance administration method.

ICD-10-PCS Codes

63 rows

ICD-10-PCS Code	Description
3E03002	Introduction of High-dose Interleukin-2 into Peripheral Vein, Open Approach
3E03003	Introduction of Low-dose Interleukin-2 into Peripheral Vein, Open Approach
3E03005	Introduction of Other Antineoplastic into Peripheral Vein, Open Approach
3E0300M	Introduction of Antineoplastic, Monoclonal Antibody, into Peripheral Vein, Open Approach
3E0300P	Introduction of Clofarabine into Peripheral Vein, Open Approach
3E03016	Introduction of Recombinant Human-activated Protein C into Peripheral Vein, Open
3E03017	Introduction of Other Thrombolytic into Peripheral Vein, Open Approach
3E03028	Introduction of Oxazolidinones into Peripheral Vein, Open Approach
3E03029	Introduction of Other Anti-infective into Peripheral Vein, Open Approach
3E0303Z	Introduction of Anti-inflammatory into Peripheral Vein, Open Approach

Showing 1–10 of 63

DRG Codes

10 rows

DRG Code	Description
037	Extracranial Procedures with MCC
038	Extracranial Procedures with CC
039	Extracranial Procedures without CC/MCC
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC
263	Vein Ligation and Stripping
673	Other Kidney and Urinary Tract Procedures with MCC
674	Other Kidney and Urinary Tract Procedures with CC
675	Other Kidney and Urinary Tract Procedures without CC/MCC

Typical Clinical Scenarios

An adult oncology patient admitted for inpatient chemotherapy administration via a peripheral IV because central access is not available or contraindicated. The care team delivers an antineoplastic agent peripherally under monitored inpatient observation to manage systemic malignancy and monitor for infusion reactions. The procedure documented is the introduction of an antineoplastic agent into a peripheral vein by percutaneous IV access. Typical codes: 3E03305, 3E0330M
An elderly patient presents to the hospital with severe cellulitis and systemic signs of infection requiring inpatient IV antibiotic therapy. A percutaneous peripheral IV line is used to deliver anti-infective agents for rapid bactericidal treatment and stabilization. The documented procedure is the introduction of an anti-infective into a peripheral vein. Typical codes: 3E03328, 3E03329
A hospitalized patient with severe rheumatoid arthritis experiences an acute flare inadequately controlled by oral therapy and is admitted for escalating biologic therapy. The treatment team administers a monoclonal antibody agent via peripheral IV to achieve rapid anti-inflammatory effect while monitoring for infusion-related adverse events. The procedure recorded is the percutaneous introduction of a monoclonal antineoplastic/immunomodulatory agent into a peripheral vein for anti-inflammatory effect. Typical codes: 3E0330M, 3E0333Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-PCS Codes

63 rows

ICD-10-PCS Code	Description
3E03002	Introduction of High-dose Interleukin-2 into Peripheral Vein, Open Approach
3E03003	Introduction of Low-dose Interleukin-2 into Peripheral Vein, Open Approach
3E03005	Introduction of Other Antineoplastic into Peripheral Vein, Open Approach
3E0300M	Introduction of Antineoplastic, Monoclonal Antibody, into Peripheral Vein, Open Approach
3E0300P	Introduction of Clofarabine into Peripheral Vein, Open Approach
3E03016	Introduction of Recombinant Human-activated Protein C into Peripheral Vein, Open
3E03017	Introduction of Other Thrombolytic into Peripheral Vein, Open Approach
3E03028	Introduction of Oxazolidinones into Peripheral Vein, Open Approach
3E03029	Introduction of Other Anti-infective into Peripheral Vein, Open Approach
3E0303Z	Introduction of Anti-inflammatory into Peripheral Vein, Open Approach

Showing 1–10 of 63

DRG Codes

10 rows

DRG Code	Description
037	Extracranial Procedures with MCC
038	Extracranial Procedures with CC
039	Extracranial Procedures without CC/MCC
061	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with MCC
062	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent with CC
063	Ischemic Stroke, Precerebral Occlusion or Transient Ischemia with Thrombolytic Agent without CC/MCC
263	Vein Ligation and Stripping
673	Other Kidney and Urinary Tract Procedures with MCC
674	Other Kidney and Urinary Tract Procedures with CC
675	Other Kidney and Urinary Tract Procedures without CC/MCC

Typical Clinical Scenarios

An adult oncology patient admitted for inpatient chemotherapy administration via a peripheral IV because central access is not available or contraindicated. The care team delivers an antineoplastic agent peripherally under monitored inpatient observation to manage systemic malignancy and monitor for infusion reactions. The procedure documented is the introduction of an antineoplastic agent into a peripheral vein by percutaneous IV access. Typical codes: 3E03305, 3E0330M
An elderly patient presents to the hospital with severe cellulitis and systemic signs of infection requiring inpatient IV antibiotic therapy. A percutaneous peripheral IV line is used to deliver anti-infective agents for rapid bactericidal treatment and stabilization. The documented procedure is the introduction of an anti-infective into a peripheral vein. Typical codes: 3E03328, 3E03329
A hospitalized patient with severe rheumatoid arthritis experiences an acute flare inadequately controlled by oral therapy and is admitted for escalating biologic therapy. The treatment team administers a monoclonal antibody agent via peripheral IV to achieve rapid anti-inflammatory effect while monitoring for infusion-related adverse events. The procedure recorded is the percutaneous introduction of a monoclonal antineoplastic/immunomodulatory agent into a peripheral vein for anti-inflammatory effect. Typical codes: 3E0330M, 3E0333Z

ICD-10-PCS Code For Skin And Mucous Membranes: Procedure Code Group Overview

3E01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

3E02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

3E04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

3E05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

3E06-CENTRAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Central Artery: Procedure Code Group Overview

3E07-CORONARY-ARTERY-INTRODUCTION

ICD-10-PCS Code for Coronary Artery: Procedure Code Group Overview

3E08-HEART-INTRODUCTION

ICD-10-PCS Code For Heart: Procedure Code Group Overview

3E09-NOSE-INTRODUCTION

ICD-10-PCS Code For Nose: Procedure Code Group Overview

3E0A-BONE-MARROW-INTRODUCTION

ICD-10-PCS Code For Bone Marrow: Procedure Code Group Overview

Showing 1–10 of 32

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview policy alerts

Peripheral Vein Introduction Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview policy alerts

Peripheral Vein Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview policy alerts

Peripheral Vein Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview policy alerts

Peripheral Vein Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation describe Peripheral Vein introduction procedures?

What body part and approaches are represented in the 3E03 code group?

How does accurate coding within the 3E03 group affect inpatient records?

Which types of substances are captured by codes in the 3E03 group?

How are related DRGs linked to procedures in the 3E03 group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation describe Peripheral Vein introduction procedures?

What body part and approaches are represented in the 3E03 code group?

How does accurate coding within the 3E03 group affect inpatient records?

Which types of substances are captured by codes in the 3E03 group?

How are related DRGs linked to procedures in the 3E03 group?

References