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    v1.0.30
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s9560-home-injectable-hormonal-therapy-home-care
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    HCPCS Level II S9560: Home Injectable Hormonal Therapy Per Diem

    HCPCS Level II code S9560 describes a per diem home injectable therapy service for hormonal therapy (for example, leuprolide or goserelin) that includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment; the service type is home-based injectable hormonal therapy with associated nursing visits and drug administration billed separately, and the typical site of service is the patient’s home or other community-based residence providing home health care.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a middle-aged woman with estrogen receptor–positive advanced breast cancer receiving home-administered depot gonadotropin-releasing hormone (GnRH) agonist therapy such as leuprolide or goserelin to suppress ovarian function. The clinical workflow begins when the treating oncologist prescribes home injectable hormonal therapy and documents indication, dosing interval, and administration instructions in the medical record. The prescription is transmitted to a professional pharmacy that provides medication counseling, prepares the appropriate depot syringe or kit, coordinates a home nursing visit for injection, and supplies necessary ancillary items (alcohol swabs, sharps container). Nursing documents pre-injection assessment (vital signs, injection site check, allergy confirmation), performs the subcutaneous or intramuscular injection, observes the patient for acute reaction, and documents the visit. Billing uses S9560 as the per diem service for home injectable therapy administrative and pharmacy professional services; the drug itself and nursing visit time are billed separately per payer policy. Care coordination tasks include scheduling, prior authorization support, and communication with the oncology clinic. Typical site of service is the patient’s home, with coordination between the oncology clinic, specialty pharmacy, and home health or visiting nurse services. Common scenarios also include palliative care patients with prostate cancer receiving similar suppression therapy, patients transitioning from clinic-based injections to home administration, or patients with mobility limitations requiring home delivery and administration.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (intramuscular or subcutaneous)Commonly billed by a visiting nurse for the actual injection administration when billed separately from S9560.
    99024Postoperative follow-up visit, included in global service (used variably)Occasionally used for follow-up communication related to therapy initiation; use depends on payer rules.
    99406Smoking and tobacco use cessation counseling, intermediateData not available in the input.
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityUsed when the prescribing clinician documents dose adjustment or side-effect management during an outpatient visit related to the home injectable therapy.
    G0008Administration of influenza virus vaccine (separate example)Data not available in the input.

    Note: Only clinically relevant CPT codes that commonly accompany home injectable hormonal therapy are shown. Some codes listed in the input were not provided; where input lacked codes, appropriate commonly performed codes were selected based on standard clinical workflows.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    163W00000X
    3336C0002X
    208M00000X
    364S00000X
    207SG0205X
    101YP2500X
    2081P2900X
    213ES0131X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    C50.911Malignant neoplasm of unspecified site of right female breast
    C50.912Malignant neoplasm of unspecified site of left female breast
    C54.9Malignant neoplasm of corpus uteri, unspecified
    C61Malignant neoplasm of prostate
    C79.51Secondary malignant neoplasm of bone
    C79.82Secondary malignant neoplasm of genital organs
    C79.9Secondary malignant neoplasm of unspecified site
    D07.1Carcinoma in situ of vulva
    D09.3Carcinoma in situ of thyroid and other endocrine glands
    D25.9Leiomyoma of uterus, unspecified

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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