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    v1.0.30
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-level-ii-s3630-eosinophil-count-blood-direct
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    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS Level II code S3630 describes a direct eosinophil count performed on a blood specimen, a hematology service used to quantify eosinophils for diagnostic and monitoring purposes; the service is a laboratory test typically performed in a clinical laboratory or hospital laboratory setting and billed as a discrete lab procedure under the HCPCS Level II coding system.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old outpatient presents to the hematology clinic with a 3-week history of progressive wheeze, episodic cough, and peripheral neuropathic symptoms. The clinician suspects eosinophilic-driven disease (for example, eosinophilic asthma or hypereosinophilic syndrome) and orders a peripheral blood eosinophil count to quantify circulating eosinophils. A venous blood sample is collected in the laboratory phlebotomy area or clinic draw station, sent to the hospital core laboratory or a reference lab, and processed on an automated hematology analyzer or by direct microscopic count if requested. Results are returned to the ordering provider and used to guide diagnosis, evaluate disease severity, monitor response to corticosteroid or biologic therapy (such as anti–IL-5 agents), and determine need for further testing (bone marrow biopsy, allergy testing, or infectious workup). Typical site of service is outpatient laboratory, clinic-based phlebotomy, or hospital laboratory. Service type: diagnostic laboratory test (hematology).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    85025Automated complete blood count (CBC) with differential WBC countCommonly ordered alongside an eosinophil count; provides absolute and percentage eosinophil values as part of the CBC differential.
    85014Blood count; leukocytes (WBC), automatedMay be performed preceding a specific eosinophil differential when leukocyte count is needed.
    88112Cytopathology, slide review by physician (eg, peripheral blood smear)Used when a manual review of the peripheral smear is required to verify or further characterize eosinophilia.
    85018Blood count; reticulocyte count, automatedOccasionally ordered in evaluation of hematologic disorders accompanying eosinophilia to assess marrow response.
    85060Hemoglobin; hematocrit determination (separate or part of CBC)Frequently part of the hematology panel ordered at the same encounter to assess overall blood indices.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    99Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207RE0101X
    207RC0000X
    163W00000X
    2084P2900X
    225X00000X
    246X00000X
    364SG0600X

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    A15.0Tuberculosis of lung
    A54.89Other gonococcal infections
    B59Pneumocystosis
    D69.6Thrombocytopenia, unspecified
    D72.829Elevated white blood cell count, unspecified
    J30.1Allergic rhinitis due to pollen
    J30.2Other seasonal allergic rhinitis
    J30.9Allergic rhinitis, unspecified
    J45.21Mild intermittent asthma with (acute) exacerbation
    J45.22Mild intermittent asthma with status asthmaticus

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    HCPCS-LEVEL-II-S9476-VESTIBULAR-REHABILITATION-PROGRAM-NON-PHYSICIAN-PER-DIEM

    HCPCS Level II S9476: Vestibular Rehabilitation Program, Per Diem

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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