HCPCS Level II code S2152 denotes a comprehensive, global bundle of services for solid organ transplantation — covering procurement, transplantation (deceased or living donor, complete or segmental, single or multiple organs), associated drugs and supplies, hospitalization, and outpatient follow-up including pre- and post-transplant care days. Nationally, this code matters because it represents a high-cost, resource-intensive episode of care that combines surgical, medical, pharmaceutical, and rehabilitative components into a single billable service. Payers commonly engaged with transplant episodes include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. This publication provides a concise reference on clinical scope and billing context for S2152, plus what readers will learn about benchmarking and policy implications: patterns of coverage across major payers, typical sites of service and service line considerations, and how the global nature of the code affects coding and billing workflows. The summary outlines where this code fits in clinical care pathways for organ transplant recipients and identifies topics for payer contract and utilization review. Data not provided in the input — such as associated taxonomies, specific ICD-10 diagnoses, and related procedure codes — are noted as unavailable for this brief.