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    v1.0.30
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-level-ii-s2152-solid-organ-transplantation-global-care
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    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS Level II code S2152 describes comprehensive procurement and transplantation services for solid organ(s), complete or segmental, from deceased or living donors, encompassing transplantation surgery, perioperative hospitalization, related medical/surgical and rehabilitative care, necessary drugs and supplies, and specified days of pre- and post-transplant follow-up; service type: organ procurement and transplantation with associated inpatient and outpatient perioperative care; typical site of service: hospital inpatient and outpatient transplant centers with possible coordination across ambulatory and rehabilitative settings.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient with end-stage liver disease secondary to hepatitis C and cirrhosis is evaluated and listed for orthotopic liver transplantation. The patient is admitted for transplantation after a suitable deceased donor organ becomes available. The multidisciplinary transplant team (transplant surgeon, transplant hepatologist, anesthesiologist, operating room staff, transplant coordinator, and pharmacists) coordinates preoperative evaluation, organ procurement logistics, perioperative care, immunosuppressive drug management, and postoperative inpatient care followed by outpatient follow-up.

    The global service described by S2152 encompasses procurement of the donor organ(s), the transplantation procedure (complete or segmental, single or combined organs), related intraoperative and postoperative medical and surgical care, hospitalization, drugs and supplies, diagnostic tests, management of complications (for example, acute rejection or vascular thrombosis), and the defined pre- and post-transplant global days. Typical workflow steps include donor organ procurement and transport, recipient operative procedure, intensive postoperative monitoring, immunosuppression initiation and titration, rehabilitation and discharge planning, and scheduled outpatient transplant clinic visits for surveillance and complication management.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    47135Hepatectomy, partial or total; for transplant recipient (explantation of diseased liver)Performed when the native liver is removed during orthotopic liver transplantation prior to implanting the donor organ.
    47136Transplantation of liver (including donor or recipient procedures), whole or partial, with or without donor hepatectomyCore surgical code for liver transplantation procedures that may be reported for specific payer billing where CPT is used instead of HCPCS II.
    50300Renal transplant, from cadaver donor; recipient procedureUsed for kidney transplant recipient procedures when renal transplantation is performed instead of or in combination with other organs.
    33945Insertion of cannulae for cardiopulmonary bypass, initiation and management (if required)May be used when cardiopulmonary bypass is required for certain combined organ transplants or complex intraoperative support.
    99605Home visit for pre-transplant evaluation (example: home evaluation for living donor)Representative of pre-transplant evaluation services that occur prior to the global transplant episode; applicable when billed separately per payer policy.
    90471Immunization administration (first vaccine)Representative of administration codes for perioperative vaccines when clinically indicated and billed separately from the global transplant service.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207L00000X
    207R00000X
    2084P0800X
    207RA0401X
    246RM2200X
    163WM0705X
    207PP0204X

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    HCPCS-LEVEL-II-S9476-VESTIBULAR-REHABILITATION-PROGRAM-NON-PHYSICIAN-PER-DIEM

    HCPCS Level II S9476: Vestibular Rehabilitation Program, Per Diem

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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