HCPCS Level II S2152: Solid Organ Transplantation Global Care - OpenPayer

Summary & Overview

HCPCS Level II S2152: Solid Organ Transplantation Global Care

HCPCS Level II code S2152 denotes a comprehensive, global bundle of services for solid organ transplantation — covering procurement, transplantation (deceased or living donor, complete or segmental, single or multiple organs), associated drugs and supplies, hospitalization, and outpatient follow-up including pre- and post-transplant care days. Nationally, this code matters because it represents a high-cost, resource-intensive episode of care that combines surgical, medical, pharmaceutical, and rehabilitative components into a single billable service. Payers commonly engaged with transplant episodes include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. This publication provides a concise reference on clinical scope and billing context for S2152, plus what readers will learn about benchmarking and policy implications: patterns of coverage across major payers, typical sites of service and service line considerations, and how the global nature of the code affects coding and billing workflows. The summary outlines where this code fits in clinical care pathways for organ transplant recipients and identifies topics for payer contract and utilization review. Data not provided in the input — such as associated taxonomies, specific ICD-10 diagnoses, and related procedure codes — are noted as unavailable for this brief.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareS2152HCPCS Level IIsolid organ transplanttransplantation bundleglobal surgical careinpatient servicesoutpatient follow-uptransplant billingorgan procurementtransplant care

Billing Code Overview

HCPCS Level II code S2152 describes comprehensive care for solid organ transplantation, including procurement and transplantation of complete or segmental single or multiple organs from deceased or living donors. The definition covers drugs, supplies, hospitalization with outpatient follow-up, medical/surgical, diagnostic, emergency, and rehabilitative services, and specifies the number of days of pre- and post-transplant care included in the global definition.

Service Type: Transplantation services and global transplant care bundle

Typical Site of Service: Inpatient hospital setting for procurement and transplantation, with associated outpatient follow-up and ancillary services

Clinical & Coding Specifications

Clinical Context

A 48-year-old patient with end-stage liver disease secondary to hepatitis C and cirrhosis is evaluated and listed for orthotopic liver transplantation. The patient is admitted for transplantation after a suitable deceased donor organ becomes available. The multidisciplinary transplant team (transplant surgeon, transplant hepatologist, anesthesiologist, operating room staff, transplant coordinator, and pharmacists) coordinates preoperative evaluation, organ procurement logistics, perioperative care, immunosuppressive drug management, and postoperative inpatient care followed by outpatient follow-up.

The global service described by S2152 encompasses procurement of the donor organ(s), the transplantation procedure (complete or segmental, single or combined organs), related intraoperative and postoperative medical and surgical care, hospitalization, drugs and supplies, diagnostic tests, management of complications (for example, acute rejection or vascular thrombosis), and the defined pre- and post-transplant global days. Typical workflow steps include donor organ procurement and transport, recipient operative procedure, intensive postoperative monitoring, immunosuppression initiation and titration, rehabilitation and discharge planning, and scheduled outpatient transplant clinic visits for surveillance and complication management.

Coding Specifications

Modifier	Description	When to Use
`22`

HCPCS S9002: Intra-vaginal Motion Sensor for Pelvic Floor Rehabilitation

HCPCS-S2300-ARTHROSCOPY-SHOULDER-THERMAL-CAPSULORRHAPHY

HCPCS S2300: Arthroscopy, Shoulder with Thermal Capsulorrhaphy

HCPCS-S1015-IV-TUBING-EXTENSION-SET

HCPCS S1015: IV Tubing Extension Set

HCPCS-LEVEL-II-S9976-LODGING-PER-DIEM-NOT-OTHERWISE-CLASSIFIED

HCPCS Level II S9976: Lodging, Per Diem, Not Otherwise Classified

HCPCS-S0028-FAMOTIDINE-INJECTION-20MG

HCPCS Level II S0028: Injection, Famotidine 20 mg

HCPCS-S8422-GRADIENT-PRESSURE-AID-SLEEVE-CUSTOM-MEDIUM-WEIGHT

HCPCS S8422: Gradient Pressure Aid Sleeve, Custom Medium Weight

HCPCS-S0622-COLLEGE-PHYSICAL-EXAM

HCPCS S0622: Physical Exam for College, New or Established Patient

HCPCS-S9502-HOME-INFUSION-ANTIBIOTIC-ANTIVIRAL-ANTIFUNGAL-ADMIN-SERVICES

HCPCS S9502: Home Infusion Administrative and Pharmacy Services

HCPCS-S2068-DIEP-SIEA-FLAP-BREAST-RECONSTRUCTION-UNILATERAL

HCPCS S2068: Unilateral DIEP/SIEA Flap Breast Reconstruction

HCPCS-S3854-GENE-EXPRESSION-PROFILING-BREAST-CANCER

HCPCS S3854: Gene Expression Profiling Panel for Breast Cancer

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Taxonomy Code	Specialty	Notes
`208800000X`	General Surgery - Transplant	Primary surgical specialty performing solid organ transplants (liver, kidney, pancreas).
`207L00000X`	Transplant Surgery	Surgeons specializing in complex organ procurement and transplantation.
`2080P0230X`	Gastroenterology	Hepatologists managing pre- and post-transplant medical care for liver transplant recipients.
`207R00000X`	Anesthesiology	Provides intraoperative anesthesia and perioperative critical care for transplant recipients.
`2084P0800X`	Organ Transplant Nursing	Specialized nursing coordinating inpatient transplant care and outpatient follow-up.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`K72.90`	Hepatic failure, unspecified, without coma	Common indication for liver transplantation in patients with end-stage liver disease.
`K74.60`	Unspecified cirrhosis of liver	Chronic liver disease that frequently progresses to end-stage liver disease necessitating transplant.
`N18.6`	End stage renal disease	Indication for kidney transplantation; relevant when combined organ transplants (e.g., liver-kidney) are performed.
`E10.65`	Type 1 diabetes mellitus with hyperglycemia	Indication for pancreas transplantation or combined pancreas-kidney transplant in select patients.
`I85.01`	Esophageal varices with bleeding	Complication of portal hypertension in cirrhosis; common pre-transplant morbidity requiring management.
`Z94.4`	Liver transplant status	Used in post-transplant care and follow-up to indicate transplant recipient status.
`T86.40`	Unspecified complication of liver transplant	Used to report postoperative complications related to the transplant that require clinical management.
`Z48.21`	Encounter for aftercare following liver transplant	Used for routine postoperative follow-up visits within the transplant global period or thereafter.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`47135`	Hepatectomy, partial or total; for transplant recipient (explantation of diseased liver)	Performed when the native liver is removed during orthotopic liver transplantation prior to implanting the donor organ.
`47136`	Transplantation of liver (including donor or recipient procedures), whole or partial, with or without donor hepatectomy	Core surgical code for liver transplantation procedures that may be reported for specific payer billing where CPT is used instead of HCPCS II.
`50300`	Renal transplant, from cadaver donor; recipient procedure	Used for kidney transplant recipient procedures when renal transplantation is performed instead of or in combination with other organs.
`33945`	Insertion of cannulae for cardiopulmonary bypass, initiation and management (if required)	May be used when cardiopulmonary bypass is required for certain combined organ transplants or complex intraoperative support.
`99605`	Home visit for pre-transplant evaluation (example: home evaluation for living donor)	Representative of pre-transplant evaluation services that occur prior to the global transplant episode; applicable when billed separately per payer policy.
`90471`	Immunization administration (first vaccine)	Representative of administration codes for perioperative vaccines when clinically indicated and billed separately from the global transplant service.

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