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    OpenPayerBilling CodesMalignant neoplasms of breastICD-10-CM c50-malignant-neoplasm-of-breast
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    ICD-10-CM Code For Malignant Neoplasm Of Breast: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C50 includes primary malignant neoplasms of the breast, including site-specific invasive cancers and specified involvement of the nipple, areola, and breast quadrants. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as tumor location, laterality, stage-related notes, and local extension or metastasis when specified, capturing disease severity and organ involvement relevant to breast cancer care. Accurate coding within the ICD-10-CM C50 group supports proper claim adjudication and complete clinical documentation and therefore appropriate reimbursement.

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    ICD-10-CM C50: Malignant Neoplasm Of Breast Overview

    The ICD-10-CM C50 group represents primary malignant tumors of the breast, including site-specific cancers of the nipple, areola, and various quadrants of the breast. These diagnoses target the breast tissue and nearby structures and cover invasive and in situ forms when specified. Accurate coding matters for clinical communication and impacts reimbursement and quality reporting by reflecting disease extent and treatment planning.

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    When to Use

    Use a code from this group when a confirmed diagnosis of primary malignant breast neoplasm is documented, with specification of site and laterality when available. Codes in this group are selected to reflect the documented tumor location, involvement of adjacent structures, and any specified in situ versus invasive status.

    ICD-10-CM Codes

    57 rows

    ICD-10-CM CodeDescription
    C50.011Malignant neoplasm of nipple and areola, right female breast
    C50.012Malignant neoplasm of nipple and areola, left female breast
    C50.019Malignant neoplasm of nipple and areola, unspecified female breast
    C50.021Malignant neoplasm of nipple and areola, right male breast
    C50.022Malignant neoplasm of nipple and areola, left male breast
    C50.029Malignant neoplasm of nipple and areola, unspecified male breast
    C50.111Malignant neoplasm of central portion of right female breast
    C50.112Malignant neoplasm of central portion of left female breast
    C50.119Malignant neoplasm of central portion of unspecified female breast
    C50.121Malignant neoplasm of central portion of right male breast
    C50.122Malignant neoplasm of central portion of left male breast
    C50.129Malignant neoplasm of central portion of unspecified male breast
    C50.211Malignant neoplasm of upper-inner quadrant of right female breast
    C50.212Malignant neoplasm of upper-inner quadrant of left female breast
    C50.219Malignant neoplasm of upper-inner quadrant of unspecified female breast
    C50.221Malignant neoplasm of upper-inner quadrant of right male breast
    C50.222Malignant neoplasm of upper-inner quadrant of left male breast
    C50.229Malignant neoplasm of upper-inner quadrant of unspecified male breast
    C50.311Malignant neoplasm of lower-inner quadrant of right female breast
    C50.312Malignant neoplasm of lower-inner quadrant of left female breast

    Showing 1–20 of 57

    DRG Codes

    5 rows

    DRG CodeDescription
    582Mastectomy for Malignancy with CC/MCC
    583Mastectomy for Malignancy without CC/MCC
    597Malignant Breast Disorders with MCC
    598Malignant Breast Disorders with CC
    599Malignant Breast Disorders without CC/MCC

    Typical Clinical Scenarios

    • An older woman presents to the oncology clinic for evaluation of a newly discovered palpable mass in the upper outer quadrant of the right breast that was first noticed two weeks ago. Imaging with diagnostic mammography and targeted ultrasound shows a suspicious spiculated mass, and core needle biopsy confirms invasive ductal carcinoma; staging and treatment planning visits follow. A code from this group is assigned to capture the primary malignant breast neoplasm at the specific location for oncologic management. Typical codes: C50.611, C50.612
    • A middle-aged patient with a history of treated left-sided breast cancer presents for routine surveillance and is found on follow-up exam to have tumor recurrence at the scar site with local skin involvement and a nonhealing ulcer overlying the previous lumpectomy area. The patient is referred for biopsy and restaging; the encounter documents active malignant disease of the specific breast subsite and local skin involvement, so a code from this group reflecting the recurrent primary site is used. Typical codes: C50.212, C50.219
    • An emergency department visit for acute onset of a painful, swollen right breast with overlying erythema in a patient known to have advanced right breast carcinoma with regional lymph node metastases presenting with superimposed inflammatory changes. The ED documents active malignant neoplasm of the breast with inflammatory signs requiring urgent evaluation and management; a site-specific malignant breast code is reported to indicate the underlying cancer contributing to the acute presentation. Typical codes: C50.311, C50.319}

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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