Summary & Overview
HCPCS Level II S9366: Home TPN, 1–2 L/day, Per Diem
HCPCS Level II code S9366 represents a per diem payment for home infusion therapy providing total parenteral nutrition (TPN) of more than one liter but no more than two liters per day. The code bundles administrative and professional pharmacy services, care coordination, and necessary supplies and equipment, and excludes separately billed drugs outside the standard formula and nursing visits. This code matters nationally as home TPN supports patients with complex nutritional needs outside inpatient settings, influences utilization of home infusion services, and affects pharmacy and care-coordination billing practices.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication provides a concise overview of the code's clinical context, typical site of service, and what services are bundled versus billed separately. Readers will find benchmark considerations for per diem home TPN services, common billing and coverage issues, and a summary of policy and coding details relevant for payers, providers, and pharmacy services. Data not available in the input for payer-specific rates, taxonomies, ICD-10 pairings, and related codes are noted where applicable.
Billing Code Overview
HCPCS Level II code S9366 describes home infusion therapy for total parenteral nutrition (TPN) provided on a per diem basis. The code covers administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment, including standard TPN formula components such as lipids and specialty amino acid formulas. It applies to TPN volumes of more than one liter but no more than two liters per day. Drugs that are not part of the standard formula and nursing visits are coded separately.
Service type: Home infusion therapy (total parenteral nutrition), per diem administrative and professional services.
Typical site of service: Patient's home (home infusion setting).
Clinical & Coding Specifications
Clinical Context
A 58-year-old patient with short bowel syndrome and chronic intestinal failure is discharged from hospital to home with a peripherally inserted central catheter (PICC) for home total parenteral nutrition (TPN). The patient requires between 1.1 and 1.8 liters of compounded TPN daily because of inadequate enteral absorption and persistent malnutrition. Home infusion pharmacy provides daily per diem administrative and professional services, care coordination, compounding of a standard TPN formula including lipids and specialty amino acid formulations, and delivery of required supplies and equipment. Nursing visits for catheter care and any separately billable drug infusions are coded and billed separately. The clinical workflow includes physician orders for TPN, home infusion pharmacy intake and benefit verification, prior authorization if required, pharmacist compounding and accuracy checks, courier delivery of TPN and supplies, daily remote or in-person monitoring and care coordination, and periodic clinic follow-up to adjust macronutrients and micronutrients based on laboratory results and weight trends.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when reporting the professional component of a service separate from technical/per diem services when applicable. |
32 |