ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E31 includes disorders of polyglandular dysfunction where two or more endocrine glands are affected, such as autoimmune polyglandular syndromes and related multi-gland endocrine failures. These ICD-10-CM diagnosis codes are used to document clinical presentations involving multiple endocrine organ involvement, disease severity, and the presence of associated autoimmune or metabolic conditions. Accurate coding within the ICD-10-CM E31 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM E31: Polyglandular Dysfunction Overview

The ICD-10-CM E31 group covers disorders characterized by dysfunction of multiple endocrine glands, including autoimmune or other etiologies leading to combined hormone deficiencies. These diagnoses target the endocrine system and commonly involve combinations of thyroid, adrenal, pancreatic, or gonadal insufficiency. Accurate coding is important for complete clinical documentation and supports appropriate reimbursement for complex endocrine care.

When to Use

Use a code from this group when a patient has documented dysfunction of multiple endocrine glands, such as concurrent thyroid and adrenal insufficiency or other multi-gland endocrine disorders. Select the specific code that reflects the identified glands, the underlying cause if known, and any documented complications to accurately represent the clinical scenario.

ICD-10-CM Codes

8 rows

ICD-10-CM Code	Description
E31.0	Autoimmune polyglandular failure
E31.1	Polyglandular hyperfunction
E31.20	Multiple endocrine neoplasia [MEN] syndrome, unspecified
E31.21	Multiple endocrine neoplasia [MEN] type I
E31.22	Multiple endocrine neoplasia [MEN] type IIA
E31.23	Multiple endocrine neoplasia [MEN] type IIB
E31.8	Other polyglandular dysfunction
E31.9	Polyglandular dysfunction, unspecified

DRG Codes

3 rows

DRG Code	Description
643	Endocrine Disorders with MCC
644	Endocrine Disorders with CC
645	Endocrine Disorders without CC/MCC

Typical Clinical Scenarios

An adult patient in primary care with long-standing autoimmune thyroid disease who is newly noted to have hypogonadism and unexplained chronic diarrhea; laboratory evaluation shows primary adrenal insufficiency and positive autoimmune markers suggesting autoimmune polyglandular syndrome. The patient presents for evaluation of multiple endocrine organ dysfunctions rather than an acute crisis, and a code from this group is assigned to capture the multisystem autoimmune endocrine disorder. Typical codes: E31.0, E31.9
A young adult admitted to the emergency department with hypotension, severe fatigue, and hyponatremia consistent with adrenal crisis; chart review reveals a history of type 1 diabetes and chronic mucocutaneous candidiasis, raising concern for a polyglandular autoimmune syndrome as the underlying etiology. The acute presentation is managed emergently, and once stabilized, a code reflecting polyglandular dysfunction is used to document the underlying multisystem endocrine disorder contributing to the crisis. Typical codes: E31.0, E31.8
A middle-aged patient seen in endocrinology for progressive symptoms of ovarian failure and recurrent hypoparathyroidism following prior autoimmune thyroiditis; the visit documents complex chronic management of multiple endocrine deficiencies requiring hormone replacement and monitoring. Because multiple endocrine glands are affected by a non-acute, chronic polyglandular process, a code from this group is assigned to reflect the chronic multisystem endocrine disorder as a comorbidity impacting treatment. Typical codes: E31.1, E31.9

Related Codes

E20-HYPOPARATHYROIDISM

ICD-10-CM Code For Hypoparathyroidism: Group Overview

E21-HYPERPARATHYROIDISM-AND-PARATHYROID-DISORDERS

ICD-10-CM Code For Hyperparathyroidism And Other Disorders Of Parathyroid Gland: Group Overview

E22-HYPERFUNCTION-OF-PITUITARY-GLAND

ICD-10-CM Code For Hyperfunction Of Pituitary Gland: Group Overview

E23-HYPOFUNCTION-OF-PITUITARY-GLAND

ICD-10-CM Code For Hypofunction And Other Disorders Of The Pituitary Gland: Group Overview

E24-CUSHINGS-SYNDROME

ICD-10-CM Code For Cushing's Syndrome: Group Overview

E25-ADRENOGENITAL-DISORDERS

ICD-10-CM Code For Adrenogenital Disorders: Group Overview

E26-HYPERALDOSTERONISM

ICD-10-CM Code For Hyperaldosteronism: Group Overview

E27-OTHER-DISORDERS-OF-ADRENAL-GLAND

ICD-10-CM Code For Other Disorders Of Adrenal Gland: Group Overview

E28-OVARIAN-DYSFUNCTION

ICD-10-CM Code For Ovarian Dysfunction: Group Overview

E29-TESTICULAR-DYSFUNCTION

ICD-10-CM Code For Testicular Dysfunction: Group Overview

Showing 1–10 of 13

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

8 rows

ICD-10-CM Code	Description
E31.0	Autoimmune polyglandular failure
E31.1	Polyglandular hyperfunction
E31.20	Multiple endocrine neoplasia [MEN] syndrome, unspecified
E31.21	Multiple endocrine neoplasia [MEN] type I
E31.22	Multiple endocrine neoplasia [MEN] type IIA
E31.23	Multiple endocrine neoplasia [MEN] type IIB
E31.8	Other polyglandular dysfunction
E31.9	Polyglandular dysfunction, unspecified

DRG Codes

3 rows

DRG Code	Description
643	Endocrine Disorders with MCC
644	Endocrine Disorders with CC
645	Endocrine Disorders without CC/MCC

Typical Clinical Scenarios

An adult patient in primary care with long-standing autoimmune thyroid disease who is newly noted to have hypogonadism and unexplained chronic diarrhea; laboratory evaluation shows primary adrenal insufficiency and positive autoimmune markers suggesting autoimmune polyglandular syndrome. The patient presents for evaluation of multiple endocrine organ dysfunctions rather than an acute crisis, and a code from this group is assigned to capture the multisystem autoimmune endocrine disorder. Typical codes: E31.0, E31.9
A young adult admitted to the emergency department with hypotension, severe fatigue, and hyponatremia consistent with adrenal crisis; chart review reveals a history of type 1 diabetes and chronic mucocutaneous candidiasis, raising concern for a polyglandular autoimmune syndrome as the underlying etiology. The acute presentation is managed emergently, and once stabilized, a code reflecting polyglandular dysfunction is used to document the underlying multisystem endocrine disorder contributing to the crisis. Typical codes: E31.0, E31.8
A middle-aged patient seen in endocrinology for progressive symptoms of ovarian failure and recurrent hypoparathyroidism following prior autoimmune thyroiditis; the visit documents complex chronic management of multiple endocrine deficiencies requiring hormone replacement and monitoring. Because multiple endocrine glands are affected by a non-acute, chronic polyglandular process, a code from this group is assigned to reflect the chronic multisystem endocrine disorder as a comorbidity impacting treatment. Typical codes: E31.1, E31.9

Related Codes

E20-HYPOPARATHYROIDISM

ICD-10-CM Code For Hypoparathyroidism: Group Overview

E21-HYPERPARATHYROIDISM-AND-PARATHYROID-DISORDERS

ICD-10-CM Code For Hyperparathyroidism And Other Disorders Of Parathyroid Gland: Group Overview

E22-HYPERFUNCTION-OF-PITUITARY-GLAND

ICD-10-CM Code For Hyperfunction Of Pituitary Gland: Group Overview

E23-HYPOFUNCTION-OF-PITUITARY-GLAND

ICD-10-CM Code For Hypofunction And Other Disorders Of The Pituitary Gland: Group Overview

E24-CUSHINGS-SYNDROME

ICD-10-CM Code For Cushing's Syndrome: Group Overview

E25-ADRENOGENITAL-DISORDERS

ICD-10-CM Code For Adrenogenital Disorders: Group Overview

E26-HYPERALDOSTERONISM

ICD-10-CM Code For Hyperaldosteronism: Group Overview

E27-OTHER-DISORDERS-OF-ADRENAL-GLAND

ICD-10-CM Code For Other Disorders Of Adrenal Gland: Group Overview

E28-OVARIAN-DYSFUNCTION

ICD-10-CM Code For Ovarian Dysfunction: Group Overview

E29-TESTICULAR-DYSFUNCTION

ICD-10-CM Code For Testicular Dysfunction: Group Overview

Showing 1–10 of 13

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

Sign up for ICD-10-CM Code For Polyglandular Dysfunction: Group Overview policy alerts

ICD-10-CM E31: Polyglandular Dysfunction Overview

ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

Sign up for ICD-10-CM Code For Polyglandular Dysfunction: Group Overview policy alerts

ICD-10-CM E31: Polyglandular Dysfunction Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which diagnoses are included in the ICD-10-CM E31 group?

How does accurate coding within `E31` support reimbursement?

What clinical situations does `E31.0` represent?

Which DRGs are related to polyglandular dysfunction codes?

When should `E31.20` versus `E31.21`–`E31.23` be used?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which diagnoses are included in the ICD-10-CM E31 group?

How does accurate coding within `E31` support reimbursement?

What clinical situations does `E31.0` represent?

Which DRGs are related to polyglandular dysfunction codes?

When should `E31.20` versus `E31.21`–`E31.23` be used?

References