Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.28
    OpenPayerBilling CodesDisorders of other endocrine glandsICD-10-CM e25-adrenogenital-disorders
    Ask Trek AI about this page

    ICD-10-CM Code For Adrenogenital Disorders: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E25 includes disorders of adrenal steroidogenesis and adrenogenital syndromes such as congenital adrenal hyperplasia and other adrenal enzymatic defects that alter androgen and sex steroid production. These ICD-10-CM diagnosis codes are used to document clinical presentations ranging from ambiguous genitalia and virilization to adrenal insufficiency and hormonal imbalance, capturing disease severity and endocrine organ involvement. Accurate coding within the ICD-10-CM E25 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

    Customize your policy alerts

    Sign up for ICD-10-CM Code For Adrenogenital Disorders: Group Overview policy alerts

    Get alerted when relevant policies change without checking for updates manually.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    ICD-10-CM E25: Adrenogenital Disorders Overview

    The ICD-10-CM E25 code group covers disorders of adrenal steroidogenesis and related adrenal conditions that affect androgen and sex steroid production. These diagnoses involve the endocrine system, particularly the adrenal glands and their role in steroid metabolism. Accurate coding matters for correct clinical documentation and appropriate reimbursement for endocrine and metabolic care.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    When to Use

    Use a code from this group when a patient has a documented adrenal steroidogenesis disorder such as congenital adrenal hyperplasia or another adrenogenital syndrome confirmed by clinical assessment and laboratory testing. Select the code that reflects the specific enzymatic defect, clinical presentation, and any documented complications or organ system involvement.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    E25.0Congenital adrenogenital disorders associated with enzyme deficiency
    E25.8Other adrenogenital disorders
    E25.9Adrenogenital disorder, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    643Endocrine Disorders with MCC
    644Endocrine Disorders with CC
    645Endocrine Disorders without CC/MCC

    Typical Clinical Scenarios

    • A pediatric patient is brought to endocrinology for progressive virilization beginning in infancy, with signs including clitoral enlargement, rapid early growth, and advanced bone age. Laboratory evaluation shows elevated androgen levels and abnormal adrenal steroidogenesis consistent with congenital adrenal hyperplasia; the visit is for diagnosis and initiation of long‑term hormonal management. Typical codes: E25.0
    • An adolescent or adult presents to primary care with new onset hirsutism, menstrual irregularities, and mild acne; outpatient workup reveals an adrenal source of excess androgens after imaging identifies an adrenal lesion and biochemical testing confirms abnormal adrenal androgen production. The diagnosis recorded relates to an acquired adrenogenital disorder causing virilizing symptoms managed in the outpatient setting. Typical codes: E25.8, E25.9
    • A hospitalized patient with known adrenal disorder develops electrolyte disturbances and worsening virilization as a complication during treatment for a concurrent illness; inpatient care focuses on stabilization, endocrine consultations, and adjustment of glucocorticoid or antiandrogen therapy. The adrenogenital disorder is listed as a comorbidity contributing to clinical management and treatment complexity. Typical codes: E25.8, E25.9

    Related Codes

    E20-HYPOPARATHYROIDISM

    ICD-10-CM Code For Hypoparathyroidism: Group Overview

    E21-HYPERPARATHYROIDISM-AND-PARATHYROID-DISORDERS

    ICD-10-CM Code For Hyperparathyroidism And Other Disorders Of Parathyroid Gland: Group Overview

    E22-HYPERFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hyperfunction Of Pituitary Gland: Group Overview

    E23-HYPOFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hypofunction And Other Disorders Of The Pituitary Gland: Group Overview

    E24-CUSHINGS-SYNDROME

    ICD-10-CM Code For Cushing's Syndrome: Group Overview

    E26-HYPERALDOSTERONISM

    ICD-10-CM Code For Hyperaldosteronism: Group Overview

    E27-OTHER-DISORDERS-OF-ADRENAL-GLAND

    ICD-10-CM Code For Other Disorders Of Adrenal Gland: Group Overview

    E28-OVARIAN-DYSFUNCTION

    ICD-10-CM Code For Ovarian Dysfunction: Group Overview

    E29-TESTICULAR-DYSFUNCTION

    ICD-10-CM Code For Testicular Dysfunction: Group Overview

    E31-POLYGLANDULAR-DYSFUNCTION

    ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.