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    v1.0.28
    OpenPayerBilling CodesDisorders of other endocrine glandsICD-10-CM e21-hyperparathyroidism-and-parathyroid-disorders
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    ICD-10-CM Code For Hyperparathyroidism And Other Disorders Of Parathyroid Gland: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E21 includes disorders of the parathyroid gland such as primary, secondary, and tertiary hyperparathyroidism, and other specified parathyroid dysfunctions that impact calcium metabolism and bone health. These ICD-10-CM diagnosis codes are used to document clinical scenarios including biochemical abnormalities, end-organ effects like nephrolithiasis or osteoporosis, or complications requiring surgical or medical management. Accurate coding within the ICD-10-CM E21 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E21: Hyperparathyroidism And Other Disorders Of Parathyroid Gland Overview

    The ICD-10-CM E21 group represents disorders of the parathyroid glands, including primary, secondary, and tertiary hyperparathyroidism as well as other functional and structural parathyroid conditions affecting calcium metabolism. These diagnoses target endocrine regulation of calcium and bone homeostasis and can have systemic effects on kidneys, bones, and neuromuscular function. Accurate coding is important for clinical documentation and for ensuring appropriate reimbursement and claim adjudication tied to the complexity of endocrine care.

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    When to Use

    Use codes from this group when a patient has documented parathyroid dysfunction such as biochemical evidence of elevated or suppressed parathyroid hormone associated with clinical effects like bone loss, nephrolithiasis, or symptomatic hypercalcemia or hypocalcemia. Assign the most specific code reflecting the type of hyperparathyroidism and any associated complications or underlying causes documented in the medical record.

    ICD-10-CM Codes

    6 rows

    ICD-10-CM CodeDescription
    E21.0Primary hyperparathyroidism
    E21.1Secondary hyperparathyroidism, not elsewhere classified
    E21.2Other hyperparathyroidism
    E21.3Hyperparathyroidism, unspecified
    E21.4Other specified disorders of parathyroid gland
    E21.5Disorder of parathyroid gland, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    643Endocrine Disorders with MCC
    644Endocrine Disorders with CC
    645Endocrine Disorders without CC/MCC

    Typical Clinical Scenarios

    • An adult patient presents to the emergency department with sudden onset severe bone pain, polyuria, dehydration, constipation, and a serum calcium level markedly elevated on labs. Imaging and parathyroid hormone (PTH) testing confirm a solitary parathyroid adenoma causing primary hyperparathyroidism with hypercalcemic crisis; a code from this group is assigned to document the endocrine cause of the hypercalcemia. Typical codes: E21.0, E21.1
    • A middle-aged patient in outpatient endocrinology follow-up has chronic mild hypercalcemia identified incidentally on routine labs, with elevated PTH and symptoms of osteoporosis and nephrolithiasis over several years. The clinician documents ongoing primary hyperparathyroidism managed conservatively or monitored for surgical referral; a chronic disorder code from this group is used to capture the long-term parathyroid dysfunction. Typical codes: E21.0, E21.4
    • A hospitalized patient with known metastatic cancer develops severe hypercalcemia attributed to ectopic PTH-related peptide but workup reveals autonomous hypersecretion from hyperplastic parathyroid tissue causing secondary complications (acute kidney injury and mental status changes). A parathyroid disorder code is assigned to denote the parathyroid contribution to the acute metabolic and organ dysfunction as a comorbidity. Typical codes: E21.2, E21.3}

    Related Codes

    E20-HYPOPARATHYROIDISM

    ICD-10-CM Code For Hypoparathyroidism: Group Overview

    E22-HYPERFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hyperfunction Of Pituitary Gland: Group Overview

    E23-HYPOFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hypofunction And Other Disorders Of The Pituitary Gland: Group Overview

    E24-CUSHINGS-SYNDROME

    ICD-10-CM Code For Cushing's Syndrome: Group Overview

    E25-ADRENOGENITAL-DISORDERS

    ICD-10-CM Code For Adrenogenital Disorders: Group Overview

    E26-HYPERALDOSTERONISM

    ICD-10-CM Code For Hyperaldosteronism: Group Overview

    E27-OTHER-DISORDERS-OF-ADRENAL-GLAND

    ICD-10-CM Code For Other Disorders Of Adrenal Gland: Group Overview

    E28-OVARIAN-DYSFUNCTION

    ICD-10-CM Code For Ovarian Dysfunction: Group Overview

    E29-TESTICULAR-DYSFUNCTION

    ICD-10-CM Code For Testicular Dysfunction: Group Overview

    E31-POLYGLANDULAR-DYSFUNCTION

    ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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