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    v1.0.28
    OpenPayerBilling CodesDisorders of other endocrine glandsICD-10-CM e24-cushings-syndrome
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    ICD-10-CM Code For Cushing's Syndrome: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E24 includes diagnoses for Cushing's syndrome and related hypercortisolism disorders, covering endogenous causes such as pituitary or adrenal neoplasms and exogenous steroid-induced states. These ICD-10-CM diagnosis codes are used to document clinical scenarios that capture disease severity, source of cortisol excess, and associated metabolic or organ system involvement. Accurate coding within the ICD-10-CM E24 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E24: Cushing's Syndrome Overview

    The ICD-10-CM E24 group represents diagnoses related to Cushing's syndrome, a disorder of excess cortisol affecting the endocrine system. These codes capture endogenous and exogenous causes of hypercortisolism and associated clinical manifestations. Accurate coding matters for appropriate claim processing and reflects the intensity of medical management and monitoring required.

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    When to Use

    Use codes from this group when a patient has documented clinical and biochemical evidence of Cushing's syndrome or when treatment is specifically directed at hypercortisolism. Select codes that reflect the underlying cause (pituitary, adrenal, ectopic, or exogenous) and any documented complications or manifestations.

    ICD-10-CM Codes

    7 rows

    ICD-10-CM CodeDescription
    E24.0Pituitary-dependent Cushing's disease
    E24.1Nelson's syndrome
    E24.2Drug-induced Cushing's syndrome
    E24.3Ectopic ACTH syndrome
    E24.4Alcohol-induced pseudo-Cushing's syndrome
    E24.8Other Cushing's syndrome
    E24.9Cushing's syndrome, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    643Endocrine Disorders with MCC
    644Endocrine Disorders with CC
    645Endocrine Disorders without CC/MCC

    Typical Clinical Scenarios

    • A 45-year-old woman with progressive weight gain, centripetal obesity, facial rounding, easy bruising, proximal muscle weakness, and new-onset hypertension presents to her primary care clinic for evaluation of chronic endocrine symptoms. Initial outpatient workup including 24-hour urinary free cortisol and dexamethasone suppression testing suggests endogenous hypercortisolism from a pituitary or adrenal source; she is referred to endocrinology for further localization studies. A diagnosis from this group is assigned to capture the classic, active syndrome of cortisol excess. Typical codes: E24.0, E24.9
    • A 28-year-old pregnant patient presents to the emergency department with severe hypertension, hyperglycemia, and worsening edema; she reports a history of treated Cushing’s disease with recent recurrence of symptoms during pregnancy. Acute management focuses on blood pressure and glucose control while coordinating urgent endocrine and obstetric care; a code from this group is used to document active Cushingoid hypercortisolism complicating pregnancy or acute presentation. Typical codes: E24.1, E24.9
    • A 60-year-old man with chronic exogenous glucocorticoid therapy for polymyalgia rheumatica develops features of cortisol excess, recurrent infections, and osteoporosis; he is seen in clinic for medication reconciliation and management of comorbidities. The diagnosis code from this group is used to identify iatrogenic or specified forms of Cushing syndrome as a comorbidity that affects treatment decisions and risk stratification. Typical codes: E24.2, E24.8

    Related Codes

    E20-HYPOPARATHYROIDISM

    ICD-10-CM Code For Hypoparathyroidism: Group Overview

    E21-HYPERPARATHYROIDISM-AND-PARATHYROID-DISORDERS

    ICD-10-CM Code For Hyperparathyroidism And Other Disorders Of Parathyroid Gland: Group Overview

    E22-HYPERFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hyperfunction Of Pituitary Gland: Group Overview

    E23-HYPOFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hypofunction And Other Disorders Of The Pituitary Gland: Group Overview

    E25-ADRENOGENITAL-DISORDERS

    ICD-10-CM Code For Adrenogenital Disorders: Group Overview

    E26-HYPERALDOSTERONISM

    ICD-10-CM Code For Hyperaldosteronism: Group Overview

    E27-OTHER-DISORDERS-OF-ADRENAL-GLAND

    ICD-10-CM Code For Other Disorders Of Adrenal Gland: Group Overview

    E28-OVARIAN-DYSFUNCTION

    ICD-10-CM Code For Ovarian Dysfunction: Group Overview

    E29-TESTICULAR-DYSFUNCTION

    ICD-10-CM Code For Testicular Dysfunction: Group Overview

    E31-POLYGLANDULAR-DYSFUNCTION

    ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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