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    v1.0.28
    OpenPayerBilling CodesDisorders of other endocrine glandsICD-10-CM e22-hyperfunction-of-pituitary-gland
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    ICD-10-CM Code For Hyperfunction Of Pituitary Gland: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E22 includes disorders of pituitary hypersecretion such as acromegaly, pituitary-dependent Cushing syndrome, and hyperprolactinemia that reflect excessive production of growth hormone, adrenocorticotropic hormone, or prolactin. These ICD-10-CM diagnosis codes are used to document clinical presentations, laboratory and imaging confirmation, and complications related to pituitary hormone excess. Accurate coding within the ICD-10-CM E22 group supports complete clinical documentation, proper claim adjudication, and appropriate reimbursement.

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    ICD-10-CM E22: Hyperfunction Of Pituitary Gland Overview

    The ICD-10-CM E22 code group covers disorders characterized by excess pituitary hormone production, including conditions such as acromegaly and hyperprolactinemia. These diagnoses target the endocrine system, specifically pituitary gland hypersecretion that can affect multiple organs and metabolic processes. Accurate coding matters for reimbursement because it links clinical findings and treatment intensity to appropriate claim adjudication and billing.

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    When to Use

    Use a code from this group when clinical evaluation, laboratory testing, and imaging support a diagnosis of pituitary hormone hypersecretion or a named syndrome such as acromegaly or pituitary-dependent Cushing syndrome. Assign codes that reflect documented etiology, hormone excess type, and any associated complications or manifestations.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    E22.0Acromegaly and pituitary gigantism
    E22.1Hyperprolactinemia
    E22.2Syndrome of inappropriate secretion of antidiuretic hormone
    E22.8Other hyperfunction of pituitary gland
    E22.9Hyperfunction of pituitary gland, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    643Endocrine Disorders with MCC
    644Endocrine Disorders with CC
    645Endocrine Disorders without CC/MCC

    Related Codes

    E20-HYPOPARATHYROIDISM

    ICD-10-CM Code For Hypoparathyroidism: Group Overview

    E21-HYPERPARATHYROIDISM-AND-PARATHYROID-DISORDERS

    ICD-10-CM Code For Hyperparathyroidism And Other Disorders Of Parathyroid Gland: Group Overview

    E23-HYPOFUNCTION-OF-PITUITARY-GLAND

    ICD-10-CM Code For Hypofunction And Other Disorders Of The Pituitary Gland: Group Overview

    E24-CUSHINGS-SYNDROME

    ICD-10-CM Code For Cushing's Syndrome: Group Overview

    E25-ADRENOGENITAL-DISORDERS

    ICD-10-CM Code For Adrenogenital Disorders: Group Overview

    E26-HYPERALDOSTERONISM

    ICD-10-CM Code For Hyperaldosteronism: Group Overview

    E27-OTHER-DISORDERS-OF-ADRENAL-GLAND

    ICD-10-CM Code For Other Disorders Of Adrenal Gland: Group Overview

    E28-OVARIAN-DYSFUNCTION

    ICD-10-CM Code For Ovarian Dysfunction: Group Overview

    E29-TESTICULAR-DYSFUNCTION

    ICD-10-CM Code For Testicular Dysfunction: Group Overview

    E31-POLYGLANDULAR-DYSFUNCTION

    ICD-10-CM Code For Polyglandular Dysfunction: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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