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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Salivary Gland and DuctsCPT cpt-42405-salivary-gland-biopsy-external-incision
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    CPT 42405: Open Incisional Biopsy of Salivary Gland

    Medicare pays $317 on average nationally for this procedure.

    CPT code 42405 describes an open incisional biopsy of a salivary gland where the provider obtains tissue samples through a skin incision and sends specimens for pathological analysis; service type: surgical biopsy of salivary gland (open/incisional); typical site of service: outpatient surgical suite, ambulatory surgery center, or hospital operating room for head and neck procedures.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient presents to an outpatient otolaryngology clinic with a palpable, slowly enlarging, firm mass in the region of the parotid gland, intermittent local discomfort, and recent focal facial paresthesia. Imaging with ultrasound or MRI demonstrates a discrete salivary gland lesion suspicious for neoplasm. The patient is scheduled for an excisional or incisional salivary gland biopsy performed under local anesthesia with a small skin incision directly over the gland. The provider obtains representative tissue samples and sends them for histopathological examination, including routine H&E and, if indicated, immunohistochemical stains. Typical workflow: preoperative consent and brief history/physical, marking and sterile preparation of the surgical site, administration of local anesthesia (or monitored anesthesia care if indicated), skin incision and dissection to the salivary gland, tissue sampling (partial excision or core of lesion), hemostasis, layered closure of the incision, postoperative instructions, and specimen submission with pathology requisition.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    42400Exploratory operation on salivary glandRelated operative exploration when more extensive gland evaluation or excision is required beyond biopsy.
    42410Excision of salivary gland tumor (partial or superficial)Performed when biopsy results indicate need for tumor excision; definitive surgical treatment following diagnostic biopsy.
    42320Excision of lesion of floor of mouth (for minor salivary gland lesions)Related when minor salivary gland lesions in the oral cavity require excision rather than gland biopsy.
    10021Fine needle aspiration without imaging guidanceA less invasive diagnostic alternative often performed prior to open biopsy for cytologic diagnosis.
    76942Ultrasonic guidance for needle placement (eg, biopsy)Used when image guidance (ultrasound) assists in localization for percutaneous or targeted sampling of salivary lesions.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    207K00000X
    2083B0002X
    204D00000X
    213E00000X
    2471Q0001X
    246QL0901X
    385HR2065X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    C07Malignant neoplasm of parotid gland
    C08.0Malignant neoplasm of submandibular gland
    C08.1Malignant neoplasm of sublingual gland
    C08.9Malignant neoplasm of major salivary gland, unspecified
    D48.0Neoplasm of uncertain behavior of bone and articular cartilage
    G51.0Bell's palsy
    H61.23Impacted cerumen, bilateral
    J35.1Hypertrophy of tonsils
    J35.2Hypertrophy of adenoids
    K11.3Abscess of salivary gland

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-42400-PERCUTANEOUS-SALIVARY-GLAND-BIOPSY

    CPT 42400: Percutaneous Needle Biopsy of Salivary Gland

    CPT-42408-RANULA-EXCISION-FLOOR-OF-MOUTH

    CPT 42408: Excision of Ranula, Floor of Mouth

    CPT-42409-MARSUPIALIZATION-SUBLINGUAL-SALIVARY-CYST

    CPT 42409: Marsupialization of Sublingual Salivary Cyst

    CPT-42410-PAROTID-LATERAL-LOBE-TUMOR-EXCISION-NO-NERVE-DISSECTION

    CPT 42410: Excision of Tumor, Lateral Lobe of Parotid Gland, No Nerve Dissection

    CPT-42415-PAROTID-LATERAL-LOBE-EXCISION-FACIAL-NERVE-PRESERVATION

    CPT 42415: Parotidectomy, Lateral Lobe Excision with Facial Nerve Preservation

    CPT-42420-PAROTIDECTOMY-FACIAL-NERVE-PRESERVATION

    CPT 42420: Parotidectomy with Facial Nerve Preservation

    CPT-42425-PAROTID-GLAND-REMOVAL-EN-BLOC-WITHOUT-FACIAL-NERVE-PRESERVATION

    CPT 42425: Parotid Gland Removal with Tumor (Non–Nerve-Sparing)

    CPT-42426-PAROTIDECTOMY-TOTAL-WITH-RADICAL-NECK-DISSECTION-UNILATERAL

    CPT 42426: Total Parotidectomy for Tumor with Unilateral Radical Neck Dissection

    CPT-42440-SUBMANDIBULAR-GLAND-EXCISION

    CPT 42440: Submandibular Gland Excision

    CPT-42450-SUBLINGUAL-GLAND-EXCISION

    CPT 42450: Excision of Sublingual Gland

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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