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    v1.0.28
    OpenPayerBilling CodesNeoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesICD-10-CM d48-neoplasm-of-uncertain-behavior
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    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Other And Unspecified Sites: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D48 includes neoplasms of uncertain behavior affecting other and unspecified sites, encompassing lesions where malignant potential is not established and which may involve soft tissue, organ parenchyma, or mucosal surfaces. These ICD-10-CM diagnosis codes are used to document clinical scenarios where the tumor’s biologic behavior is undetermined, capturing diagnostic uncertainty, site of origin, and potential need for surveillance or further evaluation. Accurate coding within the ICD-10-CM D48 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM D48: Neoplasm Of Uncertain Behavior Of Other And Unspecified Sites Overview

    This code group covers neoplasms for which the biologic behavior is uncertain, located in various organs and soft tissues. These conditions target tissues where it is unclear whether the lesion is benign or malignant. Accurate coding matters for proper claim processing and reflects clinical uncertainty that can affect treatment planning and reimbursement.

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    When to Use

    Use a code from this group when clinical, histologic, or radiologic information documents a neoplasm with uncertain behavior at an identified or unspecified site. These codes apply when further workup is pending or when the treating clinician records uncertainty about malignant potential.

    ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    D48.0Neoplasm of uncertain behavior of bone and articular cartilage
    D48.110Desmoid tumor of head and neck
    D48.111Desmoid tumor of chest wall
    D48.112Desmoid tumor, intrathoracic
    D48.113Desmoid tumor of abdominal wall
    D48.114Desmoid tumor, intraabdominal
    D48.115Desmoid tumor of upper extremity and shoulder girdle
    D48.116Desmoid tumor of lower extremity and pelvic girdle
    D48.117Desmoid tumor of back
    D48.118Desmoid tumor of other site
    D48.119Desmoid tumor of unspecified site
    D48.19Other specified neoplasm of uncertain behavior of connective and other soft tissue
    D48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
    D48.3Neoplasm of uncertain behavior of retroperitoneum
    D48.4Neoplasm of uncertain behavior of peritoneum
    D48.5Neoplasm of uncertain behavior of skin
    D48.60Neoplasm of uncertain behavior of unspecified breast
    D48.61Neoplasm of uncertain behavior of right breast
    D48.62Neoplasm of uncertain behavior of left breast
    D48.7Neoplasm of uncertain behavior of other specified sites

    Showing 1–20 of 21

    DRG Codes

    27 rows

    DRG CodeDescription
    374Digestive Malignancy with MCC
    375Digestive Malignancy with CC
    376Digestive Malignancy without CC/MCC
    456Spinal Fusion Except Cervical with Spinal Curvature, Malignancy, Infection or Extensive Fusions with MCC
    457Spinal Fusion Except Cervical with Spinal Curvature, Malignancy, Infection or Extensive Fusions with CC
    458Spinal Fusion Except Cervical with Spinal Curvature, Malignancy, Infection or Extensive Fusions without CC/MCC
    542Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy with MCC
    543Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy with CC
    544Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy without CC/MCC
    564Other Musculoskeletal System and Connective Tissue Diagnoses with MCC
    565Other Musculoskeletal System and Connective Tissue Diagnoses with CC
    566Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC
    582Mastectomy for Malignancy with CC/MCC
    583Mastectomy for Malignancy without CC/MCC
    597Malignant Breast Disorders with MCC
    598Malignant Breast Disorders with CC
    599Malignant Breast Disorders without CC/MCC
    606Minor Skin Disorders with MCC
    607Minor Skin Disorders without MCC
    826Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC

    Showing 1–20 of 27

    Typical Clinical Scenarios

    • An adult in their 60s presents to a surgical clinic after incidental finding of a solitary pulmonary nodule on chest CT obtained for evaluation of chronic cough. The lesion is biopsied and pathology reports a neoplasm of uncertain behavior of the lung/bronchus, prompting surveillance and potential further staging rather than definitive malignant coding; this situation is coded to reflect an uncertain-behavior neoplasm of respiratory site. Typical codes: D48.3.
    • A middle-aged patient with a slowly enlarging, painless mass in the parotid region is evaluated by ENT; fine needle aspiration is inconclusive for malignancy and surgical excision yields pathology interpretable as a neoplasm of uncertain behavior of salivary gland. Because the histology does not meet criteria for benign or malignant designation, the uncertain-behavior code for salivary glands is assigned to guide follow-up and possible additional treatment planning. Typical codes: D48.0.
    • An elderly resident of a long-term care facility develops anemia and constitutional decline; bone marrow biopsy demonstrates a myelodysplastic process reported as neoplasm of uncertain behavior of bone marrow (myelodysplastic syndrome category when specified), leading to hematology consultation for monitoring and supportive care rather than acute cancer therapy. Typical codes: D48.7, D48.61.

    Related Codes

    D37-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-ORAL-CAVITY-DIGESTIVE-ORGANS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Oral Cavity And Digestive Organs: Group Overview

    D38-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-MIDDLE-EAR-RESPIRATORY

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Middle Ear And Respiratory And Intrathoracic Organs: Group Overview

    D39-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-FEMALE-GENITAL

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Female Genital Organs: Group Overview

    D40-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-MALE-GENITAL

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Male Genital Organs: Group Overview

    D41-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-URINARY-ORGANS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Urinary Organs: Group Overview

    D43-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-BRAIN-CNS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Brain And Central Nervous System: Group Overview

    D44-NEOPLASM-OF-UNCERTAIN-ENDOCRINE-BEHAVIOR

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Endocrine Glands: Group Overview

    D45-POLYCYTHEMIA-VERA

    ICD-10-CM Code For Polycythemia Vera: Group Overview

    D46-MYELODYSPLASTIC-SYNDROMES

    ICD-10-CM Code For Myelodysplastic Syndromes: Group Overview

    D47-OTHER-NEOPLASMS-UNCERTAIN-BEHAVIOR

    ICD-10-CM Code For Other Neoplasms Of Uncertain Behavior Of Lymphoid Hematopoietic And Related Tissue: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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