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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Salivary Gland and DuctsCPT cpt-42425-parotid-gland-removal-en-bloc-without-facial-nerve-preservation
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    CPT 42425: Parotid Gland Removal with Tumor (Non–Nerve-Sparing)

    Medicare pays $744 on average nationally for this procedure.

    CPT code 42425 describes surgical removal of the parotid gland with the tumor removed en bloc without preservation of the facial nerve; this is a parotidectomy with non–nerve-sparing excision typically performed as an operative surgical service in an inpatient or hospital outpatient surgical setting for management of parotid gland tumors when facial nerve preservation is not feasible or indicated.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old with a progressively enlarging, firm, non-tender mass in the tail of the parotid gland with imaging (ultrasound/CT/MRI) suspicious for primary salivary gland malignancy. Fine needle aspiration may be indeterminate or suggest malignant neoplasm. The surgical team schedules a radical parotidectomy with removal of the parotid gland and tumor en bloc without preservation of the facial nerve due to tumor encasement or direct invasion of the facial nerve. The operative workflow includes preoperative imaging review, informed consent discussing facial nerve sacrifice and expected facial paralysis, general anesthesia with nerve monitoring as applicable, wide exposure of the parotid region, careful oncologic resection of the gland and tumor as a single specimen, hemostasis, possible neck dissection if nodal disease is suspected, placement of drains, and postoperative recovery with plans for adjuvant radiotherapy if pathology confirms malignancy. Typical site of service is an inpatient or ambulatory hospital surgical suite for major head and neck oncologic surgery. Service type: major surgical oncology procedure of the head and neck.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    42425Radical parotidectomy — removal of parotid gland with tumor as a single unit without preservation of the facial nervePrimary procedure when the facial nerve must be sacrificed for oncologic control.
    42415Partial parotidectomy (excision of parotid tumor, superficial lobe)Often performed for benign or smaller superficial tumors as an alternative to radical parotidectomy.
    42420Total parotidectomy (removal of entire parotid gland with preservation of the facial nerve when possible)Performed when nerve can be preserved; contrasts with 42425 where nerve is sacrificed.
    38571Biopsy or excision of lymph node(s); open, deep neckCommonly performed concurrently or in staged fashion when nodal disease is suspected.
    42826Radical neck dissection including removal of internal jugular vein when indicatedMay be performed in the same operative session for advanced regional nodal metastasis.
    69990Microscopy, surgical, includes use of operating microscopeMay be used intraoperatively for nerve assessment or microsurgical reconstruction following tumor resection.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    2084P0800X
    174400000X
    261QA0900X
    347E00000X
    111NP0017X
    292200000X
    207PT0002X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    C06.9Malignant neoplasm of mouth, unspecified
    C07Malignant neoplasm of parotid gland
    C08.0Malignant neoplasm of submandibular gland
    C08.1Malignant neoplasm of sublingual gland
    C08.9Malignant neoplasm of major salivary gland, unspecified
    C09.0Malignant neoplasm of tonsillar fossa
    D11.0Benign neoplasm of parotid gland
    D11.7Benign neoplasm of other major salivary glands
    D11.9Benign neoplasm of major salivary gland, unspecified
    D33.1Benign neoplasm of brain, infratentorial

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-42400-PERCUTANEOUS-SALIVARY-GLAND-BIOPSY

    CPT 42400: Percutaneous Needle Biopsy of Salivary Gland

    CPT-42405-SALIVARY-GLAND-BIOPSY-EXTERNAL-INCISION

    CPT 42405: Open Incisional Biopsy of Salivary Gland

    CPT-42408-RANULA-EXCISION-FLOOR-OF-MOUTH

    CPT 42408: Excision of Ranula, Floor of Mouth

    CPT-42409-MARSUPIALIZATION-SUBLINGUAL-SALIVARY-CYST

    CPT 42409: Marsupialization of Sublingual Salivary Cyst

    CPT-42410-PAROTID-LATERAL-LOBE-TUMOR-EXCISION-NO-NERVE-DISSECTION

    CPT 42410: Excision of Tumor, Lateral Lobe of Parotid Gland, No Nerve Dissection

    CPT-42415-PAROTID-LATERAL-LOBE-EXCISION-FACIAL-NERVE-PRESERVATION

    CPT 42415: Parotidectomy, Lateral Lobe Excision with Facial Nerve Preservation

    CPT-42420-PAROTIDECTOMY-FACIAL-NERVE-PRESERVATION

    CPT 42420: Parotidectomy with Facial Nerve Preservation

    CPT-42426-PAROTIDECTOMY-TOTAL-WITH-RADICAL-NECK-DISSECTION-UNILATERAL

    CPT 42426: Total Parotidectomy for Tumor with Unilateral Radical Neck Dissection

    CPT-42440-SUBMANDIBULAR-GLAND-EXCISION

    CPT 42440: Submandibular Gland Excision

    CPT-42450-SUBLINGUAL-GLAND-EXCISION

    CPT 42450: Excision of Sublingual Gland

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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