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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Salivary Gland and DuctsCPT cpt-42426-parotidectomy-total-with-radical-neck-dissection-unilateral
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    CPT 42426: Total Parotidectomy for Tumor with Unilateral Radical Neck Dissection

    Medicare pays $1184 on average nationally for this procedure.

    CPT code 42426 describes surgical removal of the entire parotid gland for a tumor with a concurrent unilateral radical neck dissection; this is a major head and neck oncologic procedure typically performed in an inpatient or hospital outpatient surgical setting and involves resection of the gland and comprehensive lymphadenectomy on one side of the neck.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting with a progressively enlarging, firm parotid mass with imaging and fine-needle aspiration suggesting a malignant neoplasm (for example, mucoepidermoid carcinoma or salivary duct carcinoma) with clinically or radiographically suspicious ipsilateral cervical lymphadenopathy. The patient undergoes preoperative evaluation including head and neck CT or MRI, chest imaging for staging, and routine perioperative labs. In the operating room under general anesthesia, the surgeon performs a total parotidectomy removing the entire ipsilateral parotid gland containing the tumor and performs a unilateral radical neck dissection (removal of lymphatic levels I–V with preservation or sacrifice of structures as indicated). Intraoperative considerations include facial nerve identification and monitoring, hemostasis, and possible reconstruction of soft-tissue defects. Postoperative care includes monitoring for facial nerve function, wound care, drainage management, pain control, and coordination with radiation oncology for adjuvant therapy if pathology confirms high‑risk features. Typical site of service is an inpatient hospital operating room or ambulatory surgical center with anticipated admission when extensive neck dissection or expected reconstruction is performed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    42426Excision of parotid gland, total, with radical neck dissection, unilateralPrimary procedure described
    69990Microsurgical techniques, requiring use of an operating microscope (list separately in addition to code for primary procedure)May be used if microsurgical repair of facial nerve or microvascular anastomosis is performed during reconstruction
    15734Muscle, myocutaneous, or fasciocutaneous free flap with microvascular anastomosis; trunk, flapUsed when free flap reconstruction is required for large defects following tumor extirpation and neck dissection
    15736Microvascular anastomosis for free flap, trunkUsed in conjunction with free flap codes to report the microvascular component when performed
    20926Bone graft, partial or complete, mandible/maxilla; major (autograft)Occasionally used if mandibular resection and reconstruction are performed during tumor extirpation

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207X00000X
    208000000X
    2084P0800X
    364S00000X
    363LF0000X
    224L00000X
    246ZE0500X
    310400000X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C07Malignant neoplasm of parotid gland
    C08.0Malignant neoplasm of submandibular gland
    C08.1Malignant neoplasm of sublingual gland
    C08.9Malignant neoplasm of major salivary gland, unspecified
    C76.0Malignant neoplasm of head, face and neck
    C79.31Secondary malignant neoplasm of brain
    C80.1Malignant (primary) neoplasm, unspecified
    D11.0Benign neoplasm of parotid gland
    D11.7Benign neoplasm of other major salivary glands
    D11.9Benign neoplasm of major salivary gland, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-42400-PERCUTANEOUS-SALIVARY-GLAND-BIOPSY

    CPT 42400: Percutaneous Needle Biopsy of Salivary Gland

    CPT-42405-SALIVARY-GLAND-BIOPSY-EXTERNAL-INCISION

    CPT 42405: Open Incisional Biopsy of Salivary Gland

    CPT-42408-RANULA-EXCISION-FLOOR-OF-MOUTH

    CPT 42408: Excision of Ranula, Floor of Mouth

    CPT-42409-MARSUPIALIZATION-SUBLINGUAL-SALIVARY-CYST

    CPT 42409: Marsupialization of Sublingual Salivary Cyst

    CPT-42410-PAROTID-LATERAL-LOBE-TUMOR-EXCISION-NO-NERVE-DISSECTION

    CPT 42410: Excision of Tumor, Lateral Lobe of Parotid Gland, No Nerve Dissection

    CPT-42415-PAROTID-LATERAL-LOBE-EXCISION-FACIAL-NERVE-PRESERVATION

    CPT 42415: Parotidectomy, Lateral Lobe Excision with Facial Nerve Preservation

    CPT-42420-PAROTIDECTOMY-FACIAL-NERVE-PRESERVATION

    CPT 42420: Parotidectomy with Facial Nerve Preservation

    CPT-42425-PAROTID-GLAND-REMOVAL-EN-BLOC-WITHOUT-FACIAL-NERVE-PRESERVATION

    CPT 42425: Parotid Gland Removal with Tumor (Non–Nerve-Sparing)

    CPT-42440-SUBMANDIBULAR-GLAND-EXCISION

    CPT 42440: Submandibular Gland Excision

    CPT-42450-SUBLINGUAL-GLAND-EXCISION

    CPT 42450: Excision of Sublingual Gland

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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