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    OpenPayerBilling CodesDiseases and Disorders of the Digestive SystemDRG 374-digestive-malignancy-with-mcc
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    Digestive Malignancy with Major Complication or Comorbidity: Inpatient Reimbursement Overview

    DRG 374 addresses hospitalizations for digestive system malignancies accompanied by a Major Complication or Comorbidity; it encompasses a range of gastrointestinal and hepatobiliary cancers with significant additional acute conditions. This Diagnosis-Related Group matters for inpatient reimbursement because the presence of a Major Complication or Comorbidity increases case severity and typically results in higher Medicare Severity Diagnosis-Related Group–based payments to reflect greater resource use.

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    DRG 374 Overview

    DRG 374 covers hospital admissions for digestive system malignancies when a Major Complication or Comorbidity is present, typically including primary cancers of the esophagus, stomach, small intestine, colon, rectum, liver, pancreas, and biliary tract with significant additional acute problems. This Diagnosis-Related Group aggregates cases with higher resource use due to the malignant diagnosis plus severe comorbid conditions or complications that increase length of stay and intensity of services. It matters for Medicare payment because the presence of a Major Complication or Comorbidity shifts cases into a higher-weighted payment category under the Medicare Severity Diagnosis-Related Group framework. Accurate clinical documentation and coding of both the malignancy and the accompanying Major Complication or Comorbidity determine assignment to this Diagnosis-Related Group and therefore influence inpatient reimbursement.

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    Clinical Trials

    • Acute perioperative and peri-procedural intervention trials focusing on patients with advanced digestive tract cancers complicated by significant comorbidities or acute complications (for example, studies evaluating optimized perioperative care bundles, enhanced recovery protocols, or blood-conservation strategies in patients undergoing resection for colorectal, gastric, or hepatobiliary malignancies). These trials enroll inpatients who present for major oncologic surgery or emergency procedures and examine short-term outcomes such as complication rates, intensive care utilization, length of stay, and 30-day readmission; findings inform clinical pathways that can reduce severe complications and high-cost resource use common in this DRG. This research is highly relevant to providers and payers because improvements in perioperative management can lower mortality and expensive downstream care associated with major digestive malignancy complications and MCCs (major complications or comorbidities).
    • Comparative effectiveness studies of systemic and multimodality treatment strategies in hospitalized patients with advanced digestive malignancies and complex comorbidity profiles, including trials that compare sequencing of chemotherapy, targeted agents, or locoregional therapies (e.g., hepatic-directed therapies) in patients who require inpatient initiation or management. These studies target real-world inpatient populations that often have organ dysfunction, prior treatment exposure, or frailty, and aim to measure outcomes such as inpatient resource utilization, treatment-related severe adverse events, and short-term survival to guide choice of therapy in high-risk patients. Payers and health systems use this evidence to refine coverage policies and care pathways that balance clinical benefit with the high costs and toxicity risks seen in medically complex inpatients captured by this DRG.
    • Post-discharge outcomes and care-coordination trials examining transitions from hospital to home or skilled nursing for patients with digestive malignancy and major comorbidities, including randomized or pragmatic studies of intensive discharge planning, palliative care integration, or remote monitoring to prevent readmissions and manage symptom burden. These trials enroll patients at discharge after an inpatient stay for malignant digestive disease with MCC and track metrics such as 90-day readmission, emergency visits, symptom control, and end-of-life care alignment. For providers and payers, evidence from these studies supports interventions that reduce avoidable readmissions and high-cost episodic care while improving quality of life and appropriate utilization for a population at high risk of recurrent inpatient needs.

    Related Codes

    326-STOMACH-ESOPHAGEAL-AND-DUODENAL-PROCEDURES-WITH-MCC

    Stomach, Esophageal and Duodenal Procedures with MCC: Inpatient Reimbursement Overview

    327-STOMACH-ESOPHAGEAL-AND-DUODENAL-PROCEDURES-WITH-CC

    Stomach, Esophageal and Duodenal Procedures with CC: Inpatient Reimbursement Overview

    328-STOMACH-ESOPHAGEAL-AND-DUODENAL-PROCEDURES-WITHOUT-CC-MCC

    Stomach, Esophageal and Duodenal Procedures without CC/MCC: Inpatient Reimbursement Overview

    329-MAJOR-SMALL-AND-LARGE-BOWEL-PROCEDURES-WITH-MCC

    Major Small and Large Bowel Procedures with MCC: Inpatient Reimbursement Overview

    330-MAJOR-SMALL-AND-LARGE-BOWEL-PROCEDURES-WITH-CC

    Major Small and Large Bowel Procedures with CC: Inpatient Reimbursement Overview

    331-MAJOR-SMALL-AND-LARGE-BOWEL-PROCEDURES-WITHOUT-CC-MCC

    Major Small and Large Bowel Procedures without CC/MCC: Inpatient Reimbursement Overview

    332-RECTAL-RESECTION-WITH-MCC

    Rectal Resection with MCC: Inpatient Reimbursement Overview

    333-RECTAL-RESECTION-WITH-CC

    Rectal Resection with CC: Inpatient Reimbursement Overview

    334-RECTAL-RESECTION-WITHOUT-CC-MCC

    Rectal Resection without CC/MCC: Inpatient Reimbursement Overview

    335-PERITONEAL-ADHESIOLYSIS-WITH-MCC

    Peritoneal Adhesiolysis with MCC: Inpatient Reimbursement Overview

    Showing 1–10 of 57

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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