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    OpenPayerBilling CodesNeoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesICD-10-CM d43-neoplasm-of-uncertain-behavior-brain-cns
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    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Brain And Central Nervous System: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D43 includes neoplasms of the brain and central nervous system characterized by uncertain behavior, such as atypical central nervous system growths where malignancy is not confirmed. These ICD-10-CM diagnosis codes are used to document situations of diagnostic uncertainty, capture organ involvement and lesion location within the central nervous system, and reflect clinical complexity when behavior is not definitively benign or malignant. Accurate coding within the ICD-10-CM D43 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM D43: Neoplasm Of Uncertain Behavior Of Brain And Central Nervous System Overview

    This group represents neoplasms of the brain and central nervous system whose behavior cannot be clearly classified as benign or malignant. It targets intracranial and central nervous system growths where pathological behavior is uncertain and clinical course unpredictable. Accurate coding matters for reimbursement because it clarifies diagnostic uncertainty, supports appropriate claim adjudication, and ensures complete clinical documentation for payer review.

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    When to Use

    Use a code from this group when a clinician documents a central nervous system or brain neoplasm described as of uncertain behavior or when pathology reports do not confirm malignancy. These codes are also used when clinical, radiologic, or histologic information is insufficient to assign a definitive benign or malignant neoplasm code.

    ICD-10-CM Codes

    7 rows

    ICD-10-CM CodeDescription
    D43.0Neoplasm of uncertain behavior of brain, supratentorial
    D43.1Neoplasm of uncertain behavior of brain, infratentorial
    D43.2Neoplasm of uncertain behavior of brain, unspecified
    D43.3Neoplasm of uncertain behavior of cranial nerves
    D43.4Neoplasm of uncertain behavior of spinal cord
    D43.8Neoplasm of uncertain behavior of other specified parts of central nervous system
    D43.9Neoplasm of uncertain behavior of central nervous system, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    054Nervous System Neoplasms with MCC
    055Nervous System Neoplasms without MCC

    Related Codes

    D37-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-ORAL-CAVITY-DIGESTIVE-ORGANS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Oral Cavity And Digestive Organs: Group Overview

    D38-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-MIDDLE-EAR-RESPIRATORY

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Middle Ear And Respiratory And Intrathoracic Organs: Group Overview

    D39-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-FEMALE-GENITAL

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Female Genital Organs: Group Overview

    D40-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-MALE-GENITAL

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Male Genital Organs: Group Overview

    D41-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-URINARY-ORGANS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Urinary Organs: Group Overview

    D44-NEOPLASM-OF-UNCERTAIN-ENDOCRINE-BEHAVIOR

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Endocrine Glands: Group Overview

    D45-POLYCYTHEMIA-VERA

    ICD-10-CM Code For Polycythemia Vera: Group Overview

    D46-MYELODYSPLASTIC-SYNDROMES

    ICD-10-CM Code For Myelodysplastic Syndromes: Group Overview

    D47-OTHER-NEOPLASMS-UNCERTAIN-BEHAVIOR

    ICD-10-CM Code For Other Neoplasms Of Uncertain Behavior Of Lymphoid Hematopoietic And Related Tissue: Group Overview

    D48-NEOPLASM-OF-UNCERTAIN-BEHAVIOR

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Other And Unspecified Sites: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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