Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.28
    OpenPayerBilling CodesNeoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesICD-10-CM d45-polycythemia-vera
    Ask Trek AI about this page

    ICD-10-CM Code For Polycythemia Vera: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D45 includes polycythemia vera, a chronic myeloproliferative disorder characterized by increased red blood cell mass and related hematologic abnormalities. These ICD-10-CM diagnosis codes are used to document patient encounters for monitoring disease course, managing symptoms and complications such as thrombosis, and tracking treatment status. Accurate coding within the ICD-10-CM D45 group supports proper claim adjudication and complete clinical documentation and appropriate reimbursement.

    Customize your policy alerts

    Sign up for ICD-10-CM Code For Polycythemia Vera: Group Overview policy alerts

    Get alerted when relevant policies change without checking for updates manually.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    ICD-10-CM D45: Polycythemia Vera Overview

    The diagnoses in the ICD-10-CM D45 group represent polycythemia vera, a chronic myeloproliferative neoplasm characterized by an increased red blood cell mass and often elevated hemoglobin and hematocrit. This group targets hematologic and bone marrow disorders affecting oxygen-carrying capacity and blood viscosity. Accurate coding matters for reimbursement because it ensures claims reflect the medical necessity and complexity of care for monitoring and managing thrombotic risk and other complications.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    When to Use

    Use a code from this group when the clinical documentation specifically identifies polycythemia vera as the diagnosis being treated or monitored during the encounter. Codes from this group apply when disease-specific management, monitoring of blood counts, or assessment of thrombotic risk related to polycythemia vera are part of the clinical care.

    ICD-10-CM Codes

    1 rows

    ICD-10-CM CodeDescription
    D45Polycythemia vera

    DRG Codes

    9 rows

    DRG CodeDescription
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC

    Typical Clinical Scenarios

    • A 62-year-old man with months of progressive headaches, pruritus after warm showers, and episodic erythromelalgia presents to his hematologist for evaluation of persistently elevated hemoglobin and hematocrit on routine labs. A bone marrow biopsy demonstrates hypercellularity with increased red cell mass consistent with a chronic myeloproliferative neoplasm; the provider documents the diagnosis during outpatient management to guide surveillance and cytoreductive therapy choices. Typical codes: D45
    • A 48-year-old woman is evaluated in the emergency department for acute thrombosis of a deep vein in the leg; history reveals long-standing elevated hemoglobin and previous phlebotomies for a known myeloproliferative disorder. Because her thrombotic event occurs in the setting of an established proliferative red cell disorder managed as a nonmalignant neoplasm, the admitting team assigns a diagnosis from this group as a contributing hematologic condition. Typical codes: D45
    • A 70-year-old patient with chronic polycythemia under long-term follow-up develops progressive splenomegaly, worsening cytopenias, and fatigue prompting reassessment of disease status and modification of therapy. The outpatient specialist documents the underlying chronic proliferative disorder as the primary hematologic diagnosis to account for these chronic complications and to coordinate ongoing management. Typical codes: D45

    Related Codes

    D37-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-ORAL-CAVITY-DIGESTIVE-ORGANS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Oral Cavity And Digestive Organs: Group Overview

    D38-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-MIDDLE-EAR-RESPIRATORY

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Middle Ear And Respiratory And Intrathoracic Organs: Group Overview

    D39-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-FEMALE-GENITAL

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Female Genital Organs: Group Overview

    D40-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-MALE-GENITAL

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Male Genital Organs: Group Overview

    D41-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-URINARY-ORGANS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Urinary Organs: Group Overview

    D43-NEOPLASM-OF-UNCERTAIN-BEHAVIOR-BRAIN-CNS

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Brain And Central Nervous System: Group Overview

    D44-NEOPLASM-OF-UNCERTAIN-ENDOCRINE-BEHAVIOR

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Endocrine Glands: Group Overview

    D46-MYELODYSPLASTIC-SYNDROMES

    ICD-10-CM Code For Myelodysplastic Syndromes: Group Overview

    D47-OTHER-NEOPLASMS-UNCERTAIN-BEHAVIOR

    ICD-10-CM Code For Other Neoplasms Of Uncertain Behavior Of Lymphoid Hematopoietic And Related Tissue: Group Overview

    D48-NEOPLASM-OF-UNCERTAIN-BEHAVIOR

    ICD-10-CM Code For Neoplasm Of Uncertain Behavior Of Other And Unspecified Sites: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.