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    v1.0.30
    OpenPayerBilling CodesSurgical Pathology ProceduresCPT cpt-88300-level-i-surgical-pathology-gross-examination-accessioning
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    CPT 88300: Surgical Pathology, Level I Gross Examination

    Medicare pays $11 and commercial payers pay $26 on average nationally for this procedure.

    CPT code 88300 describes a Level I surgical pathology gross examination performed by a physician (typically a pathologist) that includes accessioning the specimen into the laboratory, formally receiving the specimen, evaluating and documenting gross features, and reporting findings; this is a surgical pathology service typically provided in an anatomic pathology laboratory or hospital pathology department as part of specimen processing.

    For related coverage guidance, see recent payer policy updates: Destruction of Pre-Malignant Skin Lesions, Onychomycosis diagnostic testing and coverage, Treatment of Capillary Malformations (Port Wine Stains).

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    National Reimbursement Benchmarks

    Medicare's mean rate for CPT 88300 sits at $11.3, while BUCA’s average commercial mean is notably higher at $26.2, indicating that commercial contracts captured by BUCA pay on average roughly $14.9 more than Medicare for this code. That gap highlights a meaningful premium in BUCA’s commercial portfolio versus the Medicare baseline.

    Dispersion measured as the interquartile range (P75 minus P25) varies across payers: Blue Cross Blue Shield shows the widest IQR at $9.0 (P75 $42.0 minus P25 $30.1), followed by BUCA with an IQR of $13.0 (P75 $31.0 minus P25 $19.7) — actually indicating BUCA’s contractual spread is larger than BCBS when computed from provided quartiles. The tightest distributions are Aetna and UnitedHealth Group, both with an IQR of $9.0 and $8.8 respectively (Aetna $15.5–$6.0 = $9.5; UnitedHealth Group $14.8–$6.0 = $8.8), while Cigna’s IQR is $13.8 (P75 $18.8 minus P25 $5.4), reflecting substantial variation in Cigna contracts.

    Table of contents

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to a dermatology clinic with a 1.2 cm irregular pigmented lesion on the forearm. The dermatologist performs an excisional biopsy in an outpatient procedure suite and submits the specimen to the hospital or commercial pathology laboratory. Reception staff accession the specimen, assign a unique lab identifier, and prepare it for gross examination. A pathologist performs a level I surgical pathology service (88300) consisting of accessioning confirmation, description of gross features (size, color, margins, orientation, and any visible invasion), photographing the specimen if required, and documenting gross findings in the pathology report. The specimen may be received fresh or fixed; fixation and block preparation for microscopic examination are not included in 88300. The resulting gross-only report guides the clinician on whether further tissue processing and microscopic examination (higher-level surgical pathology codes) are necessary.

    Typical site of service: hospital outpatient laboratory or independent pathology laboratory receiving outpatient surgical specimens.

    Typical clinical workflow:

    • Specimen collected by dermatologist in outpatient clinic and sent with requisition.

    • Laboratory accessioning staff log receipt and label the specimen.

    • Pathologist performs gross examination and documents findings under 88300.

    • If gross findings or clinical information indicate, the specimen is processed further with additional CPT codes for microscopic examination and diagnosis.

    Related CPT Codes

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207ZP0102X
    207ZP0101X
    207ZP0007X
    122400000X
    2086S0129X
    261QS1000X
    225A00000X
    2083A0300X

    Related ICD-10-CM Codes

    33 rows

    ICD-10-CM CodeDescription
    C18.9Malignant neoplasm of colon, unspecified
    C44.92Squamous cell carcinoma of skin, unspecified
    C44.99Other specified malignant neoplasm of skin, unspecified
    C50.911Malignant neoplasm of unspecified site of right female breast
    C61Malignant neoplasm of prostate
    C67.9Malignant neoplasm of bladder, unspecified
    D01.9Carcinoma in situ of digestive organ, unspecified
    D12.6Benign neoplasm of colon, unspecified
    D48.5Neoplasm of uncertain behavior of skin
    D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin

    Showing 1–10 of 33

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Destruction of Pre-Malignant Skin LesionsAnthem2026-10-01
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Treatment of Capillary Malformations (Port Wine Stains)universityofutahhealthplans2026-09-28
    AnzupgoCigna2026-09-15
    Zevaskyn Coverage for Recessive Dystrophic Epidermolysis BullosaCigna2026-09-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Dermatology - Anzupgo Prior Authorization PolicyCigna2026-08-05
    Light Therapy for Dermatologic Conditionsbcbsvermont2026-08-01

    Related Codes

    CPT-88302-SURGICAL-PATHOLOGY-LEVEL-II-GROSS-AND-MICROSCOPIC-EXAMINATION

    CPT 88302: Surgical Pathology, Level II Gross and Microscopic Exam

    CPT-88304-SURGICAL-PATHOLOGY-LEVEL-III-GROSS-AND-MICROSCOPIC

    CPT 88304: Surgical Pathology, Level III Examination

    CPT-88305-SURGICAL-PATHOLOGY-LEVEL-IV-EXAMINATION

    CPT 88305: Surgical Pathology, Gross and Microscopic Examination, Level IV

    CPT-88307-SURGICAL-PATHOLOGY-LEVEL-V-EXAMINATION

    CPT 88307: Surgical Pathology Level V Examination

    CPT-88309-LEVEL-VI-SURGICAL-PATHOLOGY-EXAMINATION

    CPT 88309: Level VI Surgical Pathology Examination

    CPT-88311-DECALCIFICATION-SPECIMEN-PREPARATION

    CPT 88311: Decalcification Procedure for Tissue Specimens

    CPT-88312-SPECIAL-STAIN-MICROORGANISMS-TECHNICAL-COMPONENT

    CPT 88312: Special Stain, Technical Component for Microorganisms

    CPT-88313-SPECIAL-STAIN-TECHNICAL-COMPONENT

    CPT 88313: Technical Special Stain for Group II (e.g., iron, trichrome)

    CPT-88314-FROZEN-TISSUE-HISTOCHEMICAL-SPECIAL-STAIN

    CPT 88314: Frozen Tissue Histochemical Special Stain, Interpretation

    CPT-88319-ENZYME-SPECIAL-STAIN-PATHOLOGY-INTERPRETATION

    CPT 88319: Special Stain for Enzyme Constituents, With Interpretation

    Showing 1–10 of 47

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    CPT CodeDescriptionRelationship to This Procedure
    88302Level II - Surgical pathology, gross and microscopic examinationNext-level code when limited microscopic examination is also performed after the gross (88300 covers only accession/gross).
    88304Level III - Surgical pathology, gross and microscopic examinationUsed when both gross and more comprehensive microscopic examination are performed beyond level II.
    88305Level IV - Surgical pathology, gross and microscopic examinationApplied when a more complex microscopic analysis accompanies the gross examination.
    88307Level V - Surgical pathology, gross and microscopic examinationHigher complexity microscopic examination following the initial gross exam.
    88309Level VI - Surgical pathology, gross and microscopic examinationHighest-level complex surgical pathology service used when extensive microscopic workup follows the gross accession and description.