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    OpenPayerBilling CodesClinical Brachytherapy Radiation TreatmentCPT cpt-77750-intratumoral-radioelement-infusion-hospital-admission-follow-up
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    CPT 77750: Radioelement Instillation to Destroy Tumor Cells

    Medicare pays $273 on average nationally for this procedure.

    CPT code 77750 describes infusion or instillation of a radioelement solution to destroy tumor cells, a therapeutic interventional radiation procedure that includes hospital admission and three months of follow-up care; service type: radiopharmaceutical intralesional therapy / interventional radiation therapy; typical site of service: inpatient hospital for administration and monitoring during admission with follow-up care occurring in outpatient or inpatient settings as clinically indicated.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an older adult with a primary hepatic or metastatic liver tumor referred for selective intra-arterial radioembolization using yttrium-90 (Y-90) microspheres to achieve tumoricidal radiation while sparing normal liver. The patient undergoes pre-procedure evaluation including history, labs (CBC, liver function tests, coagulation), cross-sectional imaging (contrast-enhanced CT or MRI) and angiographic mapping to assess hepatic arterial anatomy and identify extrahepatic vessels. On the day of treatment, the interventional radiology team admits the patient for the procedure, performs catheter-directed infusion of the radioelement solution into tumor-feeding arteries under fluoroscopic guidance, and monitors post-procedure recovery in PACU or an inpatient bed as indicated. The code 77750 encompasses hospital admission for the radioelement infusion and includes scheduled follow-up for up to three months to assess response, manage expected post-embolization syndrome, and monitor for complications such as radiation-induced liver disease or non-target radiation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    37243Vascular embolization or occlusion, inclusive of all radiological supervision and interpretation; for hepatic arterial infusion or embolization proceduresPerformed when tumor-directed embolization is combined with or replaces radioembolization; used for adjunctive embolization of feeders.
    36247Selective catheter placement, arterial system; each first order thoracic, abdominal, or pelvic branch, or selective catheterization of the hepatic arteryUsed for selective catheterization of the hepatic artery to deliver radioelement solution prior to infusion.
    36147Transcatheter therapy, arterial infusion for intra-arterial chemotherapy, perfusion, or embolization (depends on payer)Used in workflows where intra-arterial therapeutic infusions are performed; related technique and facility resources.
    76937Ultrasound guidance for vascular access requiring imaging supervision and interpretationMay be used for ultrasound-guided vascular access (e.g., femoral artery puncture) prior to catheterization.
    51702Insertion of temporary indwelling bladder catheter; simple (separate procedure)Used occasionally for urinary monitoring in prolonged procedures or when strict output monitoring is required.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance)Applied for concurrent medication administration (e.g., antiemetics, sedatives) when reported separately by some payers.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208D00000X
    207L00000X
    208000000X
    363A00000X
    273100000X
    207VH0002X
    364SN0800X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C22.0Liver cell carcinoma
    C22.2Hepatoblastoma
    C22.7Other specified carcinomas of liver
    C50.912Malignant neoplasm of unspecified site of left female breast
    C56.9Malignant neoplasm of unspecified ovary
    C61Malignant neoplasm of prostate
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    C67.9Malignant neoplasm of bladder, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-77761-INTRACAVITARY-BRACHYTHERAPY-IMPLANT

    CPT 77761: Intracavitary Brachytherapy, 1–4 Sources

    CPT-77762-BRACHYTHERAPY-INTRACAVITARY-INTERSTITIAL-IMPLANT

    CPT 77762: Intracavitary Brachytherapy with 5–10 Sources

    CPT-77763-INTRACAVITARY-BRACHYTHERAPY-MULTI-SOURCE-IMPLANTATION

    CPT 77763: Intracavitary Brachytherapy, >10 Radioactive Sources

    CPT-77767-SURFACE-BRACHYTHERAPY-SKIN-TUMOR-SMALL-LESION

    CPT 77767: High-Dose-Rate Brachytherapy for Skin Tumor ≤2.0 cm

    CPT-77768-SURFACE-BRACHYTHERAPY-SKIN-TUMOR-LARGE-OR-MULTIPLE-LESIONS

    CPT 77768: Surface Brachytherapy for Skin Tumor >2.0 cm

    CPT-77770-SINGLE-CHANNEL-BRACHYTHERAPY-CATHETER-PLACEMENT

    CPT 77770: Single-Channel Interstitial or Intracavitary Brachytherapy

    CPT-77771-BRACHYTHERAPY-INTERSTITIAL-INTRACAVITARY-MULTI-CHANNEL

    CPT 77771: Interstitial or Intracavitary Brachytherapy, 2–12 Channels

    CPT-77772-HIGH-DOSE-RATE-MULTI-CHANNEL-BRACHYTHERAPY

    CPT 77772: Interstitial or Intracavitary Brachytherapy, >12 Channels

    CPT-77778-INTERSTITIAL-BRACHYTHERAPY-MORE-THAN-10-SOURCES

    CPT 77778: Interstitial Brachytherapy, >10 Radioactive Sources

    CPT-77789-LOW-DOSE-RATE-SURFACE-BRACHYTHERAPY

    CPT 77789: Low–Dose–Rate Surface Brachytherapy

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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