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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of digestive organsICD-10-CM c22-malignant-neoplasm-of-liver
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    ICD-10-CM Code For Malignant Neoplasm Of Liver And Intrahepatic Bile Ducts: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C22 includes primary malignant tumors of the liver and intrahepatic bile ducts, such as hepatocellular carcinoma and intrahepatic cholangiocarcinoma, and variants specifying site and morphology. These ICD-10-CM diagnosis codes are used to document clinical encounters involving liver malignancy, capturing details like tumor location, histologic type, and extension to guide care and record severity. Accurate coding within the ICD-10-CM C22 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C22: Malignant Neoplasm Of Liver And Intrahepatic Bile Ducts Overview

    The diagnoses in the ICD-10-CM C22 group represent malignant tumors originating in the liver and the intrahepatic bile ducts, including primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma. These conditions affect the hepatobiliary system and often require detailed documentation of tumor type, site, and staging. Accurate coding matters for proper reimbursement and to reflect clinical complexity in claims and medical records.

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    When to Use

    Use a code from this group when a clinician documents a primary malignant tumor of the liver or intrahepatic bile ducts confirmed by imaging, biopsy, or surgical pathology. Apply the most specific code available to reflect tumor site, histology, and any documented extension or secondary involvement.

    ICD-10-CM Codes

    8 rows

    ICD-10-CM CodeDescription
    C22.0Liver cell carcinoma
    C22.1Intrahepatic bile duct carcinoma
    C22.2Hepatoblastoma
    C22.3Angiosarcoma of liver
    C22.4Other sarcomas of liver
    C22.7Other specified carcinomas of liver
    C22.8Malignant neoplasm of liver, primary, unspecified as to type
    C22.9Malignant neoplasm of liver, not specified as primary or secondary

    DRG Codes

    3 rows

    DRG CodeDescription
    435Malignancy of Hepatobiliary System or Pancreas with MCC
    436Malignancy of Hepatobiliary System or Pancreas with CC
    437Malignancy of Hepatobiliary System or Pancreas without CC/MCC

    Typical Clinical Scenarios

    • An elderly patient with a history of chronic hepatitis C presents to the emergency department with progressive right upper quadrant pain, new-onset jaundice, weight loss, and an enlarging liver mass on bedside ultrasound; CT confirms a primary malignant tumor arising within the liver parenchyma consistent with hepatocellular carcinoma, so a primary liver malignancy code is assigned. Typical codes: C22.0
    • A middle-aged patient with known metastatic colorectal cancer develops worsening fatigue and a focal hepatic lesion on surveillance MRI that biopsy shows as adenocarcinoma originating in intrahepatic bile ducts (cholangiocarcinoma); the patient is seen in oncology clinic for staging and treatment planning, and a coding entry for intrahepatic bile duct malignancy is used. Typical codes: C22.1, C22.8
    • A patient with long-standing cirrhosis admitted for acute decompensation is found incidentally on inpatient imaging to have multiple small malignant lesions in the liver suspicious for secondary involvement or multifocal primary malignancy; the findings are documented as malignant neoplasm of liver, unspecified when the histologic origin is not yet determined, and coded accordingly during hospitalization. Typical codes: C22.9, C22.7

    Related Codes

    C15-MALIGNANT-NEOPLASM-OF-ESOPHAGUS

    ICD-10-CM Code For Malignant Neoplasm Of Esophagus: Group Overview

    C16-MALIGNANT-NEOPLASM-OF-STOMACH

    ICD-10-CM Code For Malignant Neoplasm Of Stomach: Group Overview

    C17-MALIGNANT-NEOPLASM-OF-SMALL-INTESTINE

    ICD-10-CM Code For Malignant Neoplasm Of Small Intestine: Group Overview

    C18-MALIGNANT-NEOPLASM-OF-COLON

    ICD-10-CM Code For Malignant Neoplasm Of Colon: Group Overview

    C19-MALIGNANT-NEOPLASM-OF-RECTOSIGMOID-JUNCTION

    ICD-10-CM Code For Malignant Neoplasm Of Rectosigmoid Junction: Group Overview

    C20-MALIGNANT-NEOPLASM-OF-RECTUM

    ICD-10-CM Code For Malignant Neoplasm Of Rectum: Group Overview

    C21-MALIGNANT-NEOPLASM-OF-ANUS-AND-ANAL-CANAL

    ICD-10-CM Code For Malignant Neoplasm Of Anus And Anal Canal: Group Overview

    C23-MALIGNANT-NEOPLASM-OF-GALLBLADDER

    ICD-10-CM Code For Malignant Neoplasm Of Gallbladder: Group Overview

    C24-MALIGNANT-NEOPLASM-BILIARY-TRACT

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Parts Of Biliary Tract: Group Overview

    C26-MALIGNANT-NEOPLASM-OTHER-ILL-DEFINED-DIGESTIVE-ORGANS

    ICD-10-CM Code For Malignant Neoplasm Of Other And Ill-Defined Digestive Organs: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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