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    v1.0.30
    OpenPayerBilling CodesMalignant neoplasms of lymphoid, hematopoietic and related tissueICD-10-CM c96-other-and-unspecified-malignant-neoplasms
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    ICD-10-CM Code For Other And Unspecified Malignant Neoplasms: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C96 includes malignant neoplasms of lymphoid, hematopoietic, and related tissues that are either other specified or unspecified, covering rare or atypical lymphomas and hematologic cancers. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as unspecified lymphoid malignancies, secondary involvement of hematopoietic tissues, and cases where histology or subtype is not fully determined, capturing disease extent and complexity. Accurate coding within the ICD-10-CM C96 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C96: Other And Unspecified Malignant Neoplasms Of Lymphoid, Hematopoietic And Related Tissue Overview

    This group represents malignant neoplasms that arise in lymphoid, hematopoietic, and related tissues but are classified as other specified or unspecified types. These conditions target the lymphatic system and blood‑forming tissues and can include rare or poorly specified lymphomas and related malignancies. Accurate coding matters for correct clinical documentation and reimbursement because specificity affects claim processing and care tracking.

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    When to Use

    Use a code from this group when a malignant neoplasm is identified in lymphoid or hematopoietic tissue but does not fit a more specific International Classification of Diseases, Tenth Revision, Clinical Modification category or when subtype information is unavailable. These codes apply when pathology or clinical documentation indicates an other specified or unspecified lymphoid or hematopoietic malignancy.

    ICD-10-CM Codes

    11 rows

    ICD-10-CM CodeDescription
    C96.0Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
    C96.20Malignant mast cell neoplasm, unspecified
    C96.21Aggressive systemic mastocytosis
    C96.22Mast cell sarcoma
    C96.29Other malignant mast cell neoplasm
    C96.4Sarcoma of dendritic cells (accessory cells)
    C96.5Multifocal and unisystemic Langerhans-cell histiocytosis
    C96.6Unifocal Langerhans-cell histiocytosis
    C96.9Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified
    C96.AHistiocytic sarcoma
    C96.ZOther specified malignant neoplasms of lymphoid, hematopoietic and related tissue

    DRG Codes

    21 rows

    DRG CodeDescription
    011Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
    012Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
    013Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
    642Inborn and Other Disorders of Metabolism
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    826Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC
    827Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC
    828Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC
    829Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC
    830Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC
    843Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC
    844Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with CC

    Showing 1–20 of 21

    Typical Clinical Scenarios

    • An elderly patient presents to the oncology clinic with progressive, painless lymphadenopathy, weight loss, night sweats, and fatigue over several months. Excisional lymph node biopsy shows an aggressive, unspecified peripheral T‑cell lymphoma that does not fit other defined subtypes; staging workup excludes bone marrow‑predominant disease. A code from this group is assigned because the malignancy is a T‑cell lymphoid neoplasm not otherwise specified. Typical codes: C96.0, C96.2
    • A middle‑aged patient with prior chemotherapy for diffuse large B‑cell lymphoma develops new, rapidly enlarging extranodal masses in the skin and soft tissue and systemic symptoms; biopsy reveals a large cell lymphoma of natural killer (NK)/T‑cell type localized to cutaneous sites. The acute presentation with aggressive extranodal involvement prompts coding using a specific entry for NK/T‑cell and related large cell neoplasms when the tumor does not match more common defined lymphomas. Typical codes: C96.4, C96.5
    • A patient in long‑term hematology follow‑up with chronic cytopenias and splenomegaly undergoes bone marrow biopsy demonstrating an unclassifiable malignant hematopoietic neoplasm involving both marrow and peripheral blood, failing to meet criteria for known leukemia categories. This chronic, comorbid presentation is assigned a code from this group to capture an other or unspecified malignant neoplasm of lymphoid/hematopoietic tissue used for unclassifiable or mixed presentations. Typical codes: C96.9, C96.Z

    Related Codes

    C81-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Hodgkin Lymphoma: Group Overview

    C82-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Follicular Lymphoma: Group Overview

    C83-NON-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Non-Follicular Lymphoma: Group Overview

    C84-MATURE-T-NK-CELL-LYMPHOMAS

    ICD-10-CM Code For Mature T/NK-Cell Lymphomas: Group Overview

    C85-OTHER-SPECIFIED-AND-UNSPECIFIED-NON-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Other Specified And Unspecified Types Of Non Hodgkin Lymphoma: Group Overview

    C86-OTHER-SPECIFIED-T-NK-CELL-LYMPHOMA

    ICD-10-CM Code For Other Specified Types Of T NK Cell Lymphoma: Group Overview

    C88-MALIGNANT-IMMUNOPROLIFERATIVE-DISEASES

    ICD-10-CM Code For Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas: Group Overview

    C90-MULTIPLE-MYELOMA-AND-PLASMA-CELL-NEOPLASMS

    ICD-10-CM Code For Multiple Myeloma And Malignant Plasma Cell Neoplasms: Group Overview

    C91-LYMPHOID-LEUKEMIA

    ICD-10-CM Code For Lymphoid Leukemia: Group Overview

    C92-MYELOID-LEUKEMIA

    ICD-10-CM Code For Myeloid Leukemia: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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