Lymphoma and Non-Acute Leukemia with CC: Inpatient Reimbursement Overview

DRG 841 encompasses admissions for lymphoma and non-acute leukemia with a Complication or Comorbidity, covering inpatient care for disease manifestations, complications, or treatment-related issues. Accurate classification in this Diagnosis-Related Group affects Medicare inpatient reimbursement by reflecting higher resource intensity when Complications or Comorbidities are present.

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DRG 841 Overview

DRG 841 covers inpatient admissions for lymphoma and non-acute leukemia when a Complication or Comorbidity is present. This Diagnosis-Related Group captures patients with hematologic malignancies requiring inpatient care for disease-related symptoms, treatment complications, or supportive interventions. It matters for Medicare payment because the presence of a Complication or Comorbidity increases relative resource use and affects assignment to higher-paying Diagnosis-Related Group categories compared with cases without such comorbidities. Payers and hospital coding staff monitor this Diagnosis-Related Group to ensure accurate case mix classification and reimbursement.

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Lymphoma and Non-Acute Leukemia with CC: Inpatient Reimbursement Overview

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DRG 841 Overview

National Payment Rates

Across commercial payers the observed rate range for DRG 841 spans from about $370 up to $58K, with the widest spread seen between Anthem (min $390 to max $58K) and other payers. Reference the payer table and the chart below for payer-specific percentiles and distribution. Major payers shown include Blue Cross Blue Shield, UnitedHealth Group, Cigna, Aetna, and Anthem.

The CMS 2023 data represent national Medicare fee-for-service inpatient payments published under the CMS Provider Utilization and Payment Data program. The table below shows average total payment, average submitted covered charges, average Medicare payment amount, and total discharges for DRG 841. Values reflect national aggregates for Medicare beneficiaries only.

Average Total Payment	Average Submitted Charges	Average Medicare Payment	Total Discharges
$16K	$78K	$13K	5.4K

Patient Population

This DRG’s patient population skews toward older adults and thus includes a significant Medicare-age cohort, though there is a mixed payer mix with working-age patients covered by commercial insurers as well. Overall, Medicare represents a substantial share of discharges, with commercial payers covering a meaningful minority of cases. The age distribution is therefore primarily Medicare-age but not exclusively so.

State Payment Rates

State: Alaska1 / 49

Alaska Benchmarks

Alaska’s reimbursement range for DRG 841 spans from $25K to $39K across payers, with Cigna at the top end and Anthem and Blue Cross Blue Shield clustered at the low end. The state’s mean levels are generally higher than some national medians, highlighting a notable upward deviation versus broader national averages. See the table and chart below for the payer-level distribution.

Key Insights for Alaska

Cigna is the highest paying payer in Alaska with a mean of $39K, while Anthem and Blue Cross Blue Shield are the lowest at $25K.
Alaska’s payer range spans from $25K to $39K, a tighter and higher midrange compared with national medians where several national payers show substantially lower medians around $15K–$25K.

Clinical Trials

Trials of novel immunochemotherapy combinations and sequencing strategies for adults with aggressive or relapsed lymphoma and non-acute leukemias: these studies evaluate safety, response rates, progression-free survival, and hematologic recovery when integrating newer targeted agents or immune-based therapies with established chemoimmunotherapy backbones in inpatients who present with bulky disease, high tumor burden, or treatment-related complications. The patient populations typically include hospitalized adults with symptomatic disease, cytopenias, or therapy-refractory lymphoma/leukemia requiring intensive management; results inform inpatient resource use, transfusion needs, and length of stay which are directly relevant to hospital billing and DRG-based reimbursement. - Comparative effectiveness studies of inpatient management strategies for disease- or treatment-related complications (for example febrile neutropenia, tumor lysis syndrome, severe cytopenias, or symptomatic organ infiltration): randomized or pragmatic cohort studies compare different supportive care protocols, antimicrobial stewardship approaches, or transfusion thresholds in patients admitted under this DRG. These trials focus on hospitalized patients at high risk for infectious or metabolic complications and aim to reduce ICU transfers, readmissions, and complication-related costs, providing evidence to optimize protocols that affect payer expenditures and DRG resource intensity. - Post-discharge outcomes and care-transition interventions for patients hospitalized with lymphoma or non-acute leukemia and a complication (CC): interventional or observational studies evaluate discharge planning, early outpatient follow-up models, home-based infusion or monitoring, and readmission-reduction bundles to improve continuity of care, adherence to consolidation therapies, and surveillance for relapse. Enrolling patients recently discharged after an inpatient stay, these studies address readmission rates, outpatient utilization, and long-term survival or quality-of-life metrics, offering data that help providers and payers design value-based care pathways and predict downstream costs associated with this DRG.

Lymphoma and Leukemia with Major O.R. Procedures with MCC: Inpatient Reimbursement Overview

821-LYMPHOMA-AND-LEUKEMIA-WITH-MAJOR-O-R-PROCEDURES-WITH-CC

Lymphoma and Leukemia with Major O.R. Procedures with CC: Inpatient Reimbursement Overview

822-LYMPHOMA-AND-LEUKEMIA-WITH-MAJOR-O-R-PROCEDURES-WITHOUT-CC-MCC

Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC: Inpatient Reimbursement Overview

823-LYMPHOMA-AND-NON-ACUTE-LEUKEMIA-WITH-OTHER-PROCEDURES-WITH-MCC

Lymphoma and Non-Acute Leukemia with Other Procedures with MCC: Inpatient Reimbursement Overview

824-LYMPHOMA-AND-NON-ACUTE-LEUKEMIA-WITH-OTHER-PROCEDURES-WITH-CC

Lymphoma and Non-Acute Leukemia with Other Procedures with CC: Inpatient Reimbursement Overview

825-LYMPHOMA-AND-NON-ACUTE-LEUKEMIA-WITH-OTHER-PROCEDURES-WITHOUT-CC-MCC

Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC: Inpatient Reimbursement Overview

826-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-MAJOR-O-R-PROCEDURES-WITH-MCC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC: Inpatient Reimbursement Overview

827-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-MAJOR-O-R-PROCEDURES-WITH-CC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC: Inpatient Reimbursement Overview

828-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-MAJOR-O-R-PROCEDURES-WITHOUT-CC-MCC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms: Inpatient Reimbursement Overview

829-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-OTHER-PROCEDURES-WITH-CC-MCC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms: Inpatient Reimbursement Overview

Showing 1–10 of 27

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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National Payment Rates

Mean Rates by Payer — National — DRG 841

Average Total Payment	Average Submitted Charges	Average Medicare Payment	Total Discharges
$16K	$78K	$13K	5.4K

Patient Population

State Payment Rates

State: Alaska1 / 49

Alaska Benchmarks

Mean Rates by Payer — Alaska — DRG 841

Key Insights for Alaska

Cigna is the highest paying payer in Alaska with a mean of $39K, while Anthem and Blue Cross Blue Shield are the lowest at $25K.
Alaska’s payer range spans from $25K to $39K, a tighter and higher midrange compared with national medians where several national payers show substantially lower medians around $15K–$25K.

Clinical Trials

Trials of novel immunochemotherapy combinations and sequencing strategies for adults with aggressive or relapsed lymphoma and non-acute leukemias: these studies evaluate safety, response rates, progression-free survival, and hematologic recovery when integrating newer targeted agents or immune-based therapies with established chemoimmunotherapy backbones in inpatients who present with bulky disease, high tumor burden, or treatment-related complications. The patient populations typically include hospitalized adults with symptomatic disease, cytopenias, or therapy-refractory lymphoma/leukemia requiring intensive management; results inform inpatient resource use, transfusion needs, and length of stay which are directly relevant to hospital billing and DRG-based reimbursement. - Comparative effectiveness studies of inpatient management strategies for disease- or treatment-related complications (for example febrile neutropenia, tumor lysis syndrome, severe cytopenias, or symptomatic organ infiltration): randomized or pragmatic cohort studies compare different supportive care protocols, antimicrobial stewardship approaches, or transfusion thresholds in patients admitted under this DRG. These trials focus on hospitalized patients at high risk for infectious or metabolic complications and aim to reduce ICU transfers, readmissions, and complication-related costs, providing evidence to optimize protocols that affect payer expenditures and DRG resource intensity. - Post-discharge outcomes and care-transition interventions for patients hospitalized with lymphoma or non-acute leukemia and a complication (CC): interventional or observational studies evaluate discharge planning, early outpatient follow-up models, home-based infusion or monitoring, and readmission-reduction bundles to improve continuity of care, adherence to consolidation therapies, and surveillance for relapse. Enrolling patients recently discharged after an inpatient stay, these studies address readmission rates, outpatient utilization, and long-term survival or quality-of-life metrics, offering data that help providers and payers design value-based care pathways and predict downstream costs associated with this DRG.

Lymphoma and Leukemia with Major O.R. Procedures with MCC: Inpatient Reimbursement Overview

821-LYMPHOMA-AND-LEUKEMIA-WITH-MAJOR-O-R-PROCEDURES-WITH-CC

Lymphoma and Leukemia with Major O.R. Procedures with CC: Inpatient Reimbursement Overview

822-LYMPHOMA-AND-LEUKEMIA-WITH-MAJOR-O-R-PROCEDURES-WITHOUT-CC-MCC

Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC: Inpatient Reimbursement Overview

823-LYMPHOMA-AND-NON-ACUTE-LEUKEMIA-WITH-OTHER-PROCEDURES-WITH-MCC

Lymphoma and Non-Acute Leukemia with Other Procedures with MCC: Inpatient Reimbursement Overview

824-LYMPHOMA-AND-NON-ACUTE-LEUKEMIA-WITH-OTHER-PROCEDURES-WITH-CC

Lymphoma and Non-Acute Leukemia with Other Procedures with CC: Inpatient Reimbursement Overview

825-LYMPHOMA-AND-NON-ACUTE-LEUKEMIA-WITH-OTHER-PROCEDURES-WITHOUT-CC-MCC

Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC: Inpatient Reimbursement Overview

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Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC: Inpatient Reimbursement Overview

827-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-MAJOR-O-R-PROCEDURES-WITH-CC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC: Inpatient Reimbursement Overview

828-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-MAJOR-O-R-PROCEDURES-WITHOUT-CC-MCC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms: Inpatient Reimbursement Overview

829-MYELOPROLIFERATIVE-DISORDERS-OR-POORLY-DIFFERENTIATED-NEOPLASMS-WITH-OTHER-PROCEDURES-WITH-CC-MCC

Myeloproliferative Disorders or Poorly Differentiated Neoplasms: Inpatient Reimbursement Overview

Showing 1–10 of 27

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

Lymphoma and Non-Acute Leukemia with CC: Inpatient Reimbursement Overview

Sign up for drg 841 policy alerts

DRG 841 Overview

OpenPayer

Lymphoma and Non-Acute Leukemia with CC: Inpatient Reimbursement Overview

Sign up for drg 841 policy alerts

DRG 841 Overview

National Payment Rates

Patient Population

State Payment Rates

Alaska Benchmarks

Key Insights for Alaska

Clinical Trials

Related Codes

References

National Payment Rates

Patient Population

State Payment Rates

Alaska Benchmarks

Key Insights for Alaska

Clinical Trials

Related Codes

References