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    OpenPayerBilling CodesMalignant neoplasms of lymphoid, hematopoietic and related tissueICD-10-CM c88-malignant-immunoproliferative-diseases
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    ICD-10-CM Code For Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C88 includes malignant immunoproliferative disorders and certain other B-cell lymphomas, such as monoclonal gammopathy with malignant features and specific B-cell neoplasms. These ICD-10-CM diagnosis codes are used to document clinical presentations involving clonal B-cell proliferation, organ or marrow involvement, and related complications. Accurate coding within the ICD-10-CM C88 group supports appropriate claim adjudication and complete clinical documentation for care coordination and reimbursement.

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    ICD-10-CM C88: Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas Overview

    This group represents malignant immunoproliferative disorders and selected B-cell lymphomas that primarily affect the lymphoid and hematopoietic systems. These diagnoses target abnormal clonal proliferation of B lymphocytes and related tissues, often involving lymph nodes, bone marrow, and peripheral blood. Accurate coding matters for clinical tracking and for reimbursement because it captures disease type, progression, and treatment implications.

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    When to Use

    Use a code from this group when a documented diagnosis specifies a malignant immunoproliferative disorder or a named B-cell lymphoma that falls under the C88 classification. Apply these codes to capture disease-specific features such as marrow involvement, monoclonal protein presence, or anatomical sites affected as documented in the clinical record.

    ICD-10-CM Codes

    12 rows

    ICD-10-CM CodeDescription
    C88.00Waldenstrom macroglobulinemia not having achieved remission
    C88.01Waldenstrom macroglobulinemia, in remission
    C88.20Heavy chain disease not having achieved remission
    C88.21Heavy chain disease, in remission
    C88.30Immunoproliferative small intestinal disease not having achieved remission
    C88.31Immunoproliferative small intestinal disease, in remission
    C88.40Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission
    C88.41Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission
    C88.80Other malignant immunoproliferative diseases not having achieved remission
    C88.81Other malignant immunoproliferative diseases, in remission
    C88.90Malignant immunoproliferative disease, unspecified not having achieved remission
    C88.91Malignant immunoproliferative disease, unspecified, in remission

    DRG Codes

    12 rows

    DRG CodeDescription
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC
    974HIV with Major Related Condition with MCC
    975HIV with Major Related Condition with CC
    976HIV with Major Related Condition without CC/MCC

    Typical Clinical Scenarios

    • An elderly patient with a history of slowly progressive lymphadenopathy, fatigue, and monoclonal gammopathy is evaluated in hematology clinic after routine bloodwork shows increasing serum monoclonal protein and mild cytopenias. Bone marrow biopsy demonstrates infiltration by a monoclonal B‑cell population consistent with immunoproliferative disease (e.g., Waldenström macroglobulinemia or lymphoplasmacytic lymphoma) without acute systemic symptoms; diagnosis from this group is assigned for chronic management and staging. Typical codes: C88.01, C88.21
    • A middle‑aged patient presents to the emergency department with fever, rapidly enlarging peripheral lymph nodes, and night sweats; imaging shows diffuse lymphadenopathy and biopsy reveals a high‑grade B‑cell lymphoma with plasmacytic differentiation causing systemic symptoms. Because this is an acute presentation of a malignant B‑cell proliferative disorder requiring urgent oncologic care, an appropriate code from this group is used to document the malignant immunoproliferative neoplasm. Typical codes: C88.31, C88.41
    • A patient with a known immunoproliferative B‑cell malignancy under treatment develops symptomatic hyperviscosity syndrome and requires plasmapheresis and hospitalization; this represents a complication of the underlying malignant disorder and is coded to reflect the malignant neoplasm in the context of the complication. Typical codes: C88.80, C88.90

    Related Codes

    C81-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Hodgkin Lymphoma: Group Overview

    C82-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Follicular Lymphoma: Group Overview

    C83-NON-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Non-Follicular Lymphoma: Group Overview

    C84-MATURE-T-NK-CELL-LYMPHOMAS

    ICD-10-CM Code For Mature T/NK-Cell Lymphomas: Group Overview

    C85-OTHER-SPECIFIED-AND-UNSPECIFIED-NON-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Other Specified And Unspecified Types Of Non Hodgkin Lymphoma: Group Overview

    C86-OTHER-SPECIFIED-T-NK-CELL-LYMPHOMA

    ICD-10-CM Code For Other Specified Types Of T NK Cell Lymphoma: Group Overview

    C90-MULTIPLE-MYELOMA-AND-PLASMA-CELL-NEOPLASMS

    ICD-10-CM Code For Multiple Myeloma And Malignant Plasma Cell Neoplasms: Group Overview

    C91-LYMPHOID-LEUKEMIA

    ICD-10-CM Code For Lymphoid Leukemia: Group Overview

    C92-MYELOID-LEUKEMIA

    ICD-10-CM Code For Myeloid Leukemia: Group Overview

    C93-MONOCYTIC-LEUKEMIA

    ICD-10-CM Code For Monocytic Leukemia: Group Overview

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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