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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of lymphoid, hematopoietic and related tissueICD-10-CM c81-hodgkin-lymphoma
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    ICD-10-CM Code For Hodgkin Lymphoma: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C81 includes malignant neoplasms of Hodgkin lymphoma, covering classical Hodgkin lymphoma subtypes and nodular lymphocyte predominant Hodgkin lymphoma that primarily affect lymphatic tissues. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as initial diagnosis, recurrence, and specified anatomic site involvement, capturing disease extent and histologic subtype relevant to management. Accurate coding within the ICD-10-CM C81 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

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    ICD-10-CM C81: Hodgkin Lymphoma Overview

    The diagnoses in this group represent malignant neoplasms of lymphoid tissue characterized by the presence of Reed-Sternberg cells or related variants and primarily involve the lymphatic and hematopoietic systems. Hodgkin lymphoma commonly affects lymph nodes and can involve contiguous nodal groups and, less often, extranodal sites. Accurate coding is important for clinical documentation and supports appropriate claim adjudication and reimbursement by capturing stage, histologic subtype, and treatment intent.

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    When to Use

    Use a code from this group when documenting a confirmed diagnosis of Hodgkin lymphoma, including initial diagnosis, specified site involvement, or recurrence. Select the code that best reflects the histologic subtype and anatomic extent as documented in the medical record.

    ICD-10-CM Codes

    77 rows

    ICD-10-CM CodeDescription
    C81.00Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site
    C81.01Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of head, face, and neck
    C81.02Nodular lymphocyte predominant Hodgkin lymphoma, intrathoracic lymph nodes
    C81.03Nodular lymphocyte predominant Hodgkin lymphoma, intra-abdominal lymph nodes
    C81.04Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of axilla and upper limb
    C81.05Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
    C81.06Nodular lymphocyte predominant Hodgkin lymphoma, intrapelvic lymph nodes
    C81.07Nodular lymphocyte predominant Hodgkin lymphoma, spleen
    C81.08Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of multiple sites
    C81.09Nodular lymphocyte predominant Hodgkin lymphoma, extranodal and solid organ sites
    C81.0ANodular lymphocyte predominant Hodgkin lymphoma, in remission
    C81.10Nodular sclerosis Hodgkin lymphoma, unspecified site
    C81.11Nodular sclerosis Hodgkin lymphoma, lymph nodes of head, face, and neck
    C81.12Nodular sclerosis Hodgkin lymphoma, intrathoracic lymph nodes
    C81.13Nodular sclerosis Hodgkin lymphoma, intra-abdominal lymph nodes
    C81.14Nodular sclerosis Hodgkin lymphoma, lymph nodes of axilla and upper limb
    C81.15Nodular sclerosis Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
    C81.16Nodular sclerosis Hodgkin lymphoma, intrapelvic lymph nodes
    C81.17Nodular sclerosis Hodgkin lymphoma, spleen
    C81.18Nodular sclerosis Hodgkin lymphoma, lymph nodes of multiple sites

    Showing 1–20 of 77

    DRG Codes

    12 rows

    DRG CodeDescription
    011Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
    012Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
    013Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC

    Typical Clinical Scenarios

    • An adult presents to the oncology clinic with painless, progressive cervical and supraclavicular lymphadenopathy, night sweats, unexplained weight loss, and pruritus. Excisional lymph node biopsy confirms nodular sclerosis classical Hodgkin lymphoma; staging and initial treatment planning are initiated, so a specific primary Hodgkin lymphoma code is assigned to capture the histologic subtype and site. Typical codes: C81.10, C81.11
    • An elderly patient with a prior history of treated Hodgkin lymphoma returns for surveillance and is found on PET/CT to have recurrent disease involving mediastinal and hilar lymph nodes with B symptoms. Because this visit documents recurrent or relapsed Hodgkin lymphoma requiring restaging and potential salvage therapy, a current malignant Hodgkin lymphoma diagnosis code reflecting the appropriate subtype and recurrence is used. Typical codes: C81.12, C81.13
    • A child presents to the emergency department with rapidly enlarging peripheral lymph nodes, fever, and signs of superior vena cava syndrome from a large mediastinal mass; urgent biopsy confirms mixed cellularity classical Hodgkin lymphoma. This acute presentation with mass effect and systemic symptoms necessitates hospitalization and coding for the malignant Hodgkin lymphoma subtype responsible for the acute complication. Typical codes: C81.30, C81.31

    Related Codes

    C82-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Follicular Lymphoma: Group Overview

    C83-NON-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Non-Follicular Lymphoma: Group Overview

    C84-MATURE-T-NK-CELL-LYMPHOMAS

    ICD-10-CM Code For Mature T/NK-Cell Lymphomas: Group Overview

    C85-OTHER-SPECIFIED-AND-UNSPECIFIED-NON-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Other Specified And Unspecified Types Of Non Hodgkin Lymphoma: Group Overview

    C86-OTHER-SPECIFIED-T-NK-CELL-LYMPHOMA

    ICD-10-CM Code For Other Specified Types Of T NK Cell Lymphoma: Group Overview

    C88-MALIGNANT-IMMUNOPROLIFERATIVE-DISEASES

    ICD-10-CM Code For Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas: Group Overview

    C90-MULTIPLE-MYELOMA-AND-PLASMA-CELL-NEOPLASMS

    ICD-10-CM Code For Multiple Myeloma And Malignant Plasma Cell Neoplasms: Group Overview

    C91-LYMPHOID-LEUKEMIA

    ICD-10-CM Code For Lymphoid Leukemia: Group Overview

    C92-MYELOID-LEUKEMIA

    ICD-10-CM Code For Myeloid Leukemia: Group Overview

    C93-MONOCYTIC-LEUKEMIA

    ICD-10-CM Code For Monocytic Leukemia: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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