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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of lymphoid, hematopoietic and related tissueICD-10-CM c85-other-specified-and-unspecified-non-hodgkin-lymphoma
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    ICD-10-CM Code For Other Specified And Unspecified Types Of Non Hodgkin Lymphoma: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C85 includes other specified and unspecified types of non-Hodgkin lymphoma, covering atypical, mixed, and unclassified lymphoid malignancies that do not fall into more specific lymphoma categories. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as uncommon histologic subtypes, cases lacking definitive classification, or presentations involving multiple nodal or extranodal sites, capturing disease severity, organ involvement, or clinical complexity relevant to this group. Accurate coding within the ICD-10-CM C85 group supports proper claim adjudication / complete clinical documentation / appropriate reimbursement.

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    ICD-10-CM C85: Other Specified And Unspecified Types Of Non-Hodgkin Lymphoma Overview

    This group includes other specified and unspecified forms of non-Hodgkin lymphoma affecting lymphoid and related hematopoietic tissues. These diagnoses represent malignant neoplasms originating in the lymphatic system and sometimes involve extranodal sites. Accurate coding matters for reimbursement because it ensures the clinical complexity and treatment intensity are reflected in claims.

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    When to Use

    Use a code from this group when pathology or clinical documentation identifies a non-Hodgkin lymphoma as a specified rare subtype not elsewhere classified or when documentation does not provide sufficient detail to assign a more specific lymphoma code. These codes are appropriate for cases with atypical histology, mixed features, or incomplete diagnostic information regarding subtype.

    ICD-10-CM Codes

    44 rows

    ICD-10-CM CodeDescription
    C85.10Unspecified B-cell lymphoma, unspecified site
    C85.11Unspecified B-cell lymphoma, lymph nodes of head, face, and neck
    C85.12Unspecified B-cell lymphoma, intrathoracic lymph nodes
    C85.13Unspecified B-cell lymphoma, intra-abdominal lymph nodes
    C85.14Unspecified B-cell lymphoma, lymph nodes of axilla and upper limb
    C85.15Unspecified B-cell lymphoma, lymph nodes of inguinal region and lower limb
    C85.16Unspecified B-cell lymphoma, intrapelvic lymph nodes
    C85.17Unspecified B-cell lymphoma, spleen
    C85.18Unspecified B-cell lymphoma, lymph nodes of multiple sites
    C85.19Unspecified B-cell lymphoma, extranodal and solid organ sites
    C85.1AUnspecified B-cell lymphoma, in remission
    C85.20Mediastinal (thymic) large B-cell lymphoma, unspecified site
    C85.21Mediastinal (thymic) large B-cell lymphoma, lymph nodes of head, face, and neck
    C85.22Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes
    C85.23Mediastinal (thymic) large B-cell lymphoma, intra-abdominal lymph nodes
    C85.24Mediastinal (thymic) large B-cell lymphoma, lymph nodes of axilla and upper limb
    C85.25Mediastinal (thymic) large B-cell lymphoma, lymph nodes of inguinal region and lower limb
    C85.26Mediastinal (thymic) large B-cell lymphoma, intrapelvic lymph nodes
    C85.27Mediastinal (thymic) large B-cell lymphoma, spleen
    C85.28Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites

    Showing 1–20 of 44

    DRG Codes

    15 rows

    DRG CodeDescription
    011Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
    012Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
    013Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC
    974HIV with Major Related Condition with MCC
    975HIV with Major Related Condition with CC
    976HIV with Major Related Condition without CC/MCC

    Typical Clinical Scenarios

    • An older adult presents to oncology clinic with progressive generalized lymphadenopathy, drenching night sweats, unintended weight loss, and persistent fatigue over several months. Excisional lymph node biopsy demonstrates a high-grade, diffuse large B-cell type of non-Hodgkin lymphoma that does not fit a more specific subtype; staging workup shows no acute complications. A code from this group is assigned to capture an other specified high-grade non-Hodgkin lymphoma. Typical codes: C85.10, C85.11
    • A middle-aged patient with a history of treated indolent lymphoma returns for routine follow-up and is found to have relapsed disease limited to the spleen and bone marrow without systemic symptoms; therapy is being considered for disease control. Because the recurrent pattern represents an unspecified or other specified non-Hodgkin lymphoma not otherwise classifiable by more specific codes, a code from this group is used to record the underlying malignancy and guide longitudinal care. Typical codes: C85.90, C85.91
    • An emergency department visit for acute cytopenias and febrile neutropenia in a patient recently diagnosed with an atypical lymphoid malignancy undergoing chemotherapy; the underlying diagnosis was categorized on pathology as an unspecified T-cell non-Hodgkin lymphoma that required immediate management of treatment complications. The diagnosis group code is used on the encounter to indicate the underlying malignancy responsible for the current complication and to coordinate oncology-directed care. Typical codes: C85.20, C85.21

    Related Codes

    C81-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Hodgkin Lymphoma: Group Overview

    C82-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Follicular Lymphoma: Group Overview

    C83-NON-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Non-Follicular Lymphoma: Group Overview

    C84-MATURE-T-NK-CELL-LYMPHOMAS

    ICD-10-CM Code For Mature T/NK-Cell Lymphomas: Group Overview

    C86-OTHER-SPECIFIED-T-NK-CELL-LYMPHOMA

    ICD-10-CM Code For Other Specified Types Of T NK Cell Lymphoma: Group Overview

    C88-MALIGNANT-IMMUNOPROLIFERATIVE-DISEASES

    ICD-10-CM Code For Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas: Group Overview

    C90-MULTIPLE-MYELOMA-AND-PLASMA-CELL-NEOPLASMS

    ICD-10-CM Code For Multiple Myeloma And Malignant Plasma Cell Neoplasms: Group Overview

    C91-LYMPHOID-LEUKEMIA

    ICD-10-CM Code For Lymphoid Leukemia: Group Overview

    C92-MYELOID-LEUKEMIA

    ICD-10-CM Code For Myeloid Leukemia: Group Overview

    C93-MONOCYTIC-LEUKEMIA

    ICD-10-CM Code For Monocytic Leukemia: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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