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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of lymphoid, hematopoietic and related tissueICD-10-CM c91-lymphoid-leukemia
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    ICD-10-CM Code For Lymphoid Leukemia: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C91 includes malignant lymphoid leukemias, covering acute and chronic lymphocytic leukemias and their specified subtypes affecting blood and bone marrow. These ICD-10-CM diagnosis codes are used to document clinical presentations such as newly diagnosed disease, relapse, remission status, and complications like infections or organ infiltration. Accurate coding within the ICD-10-CM C91 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C91: Lymphoid Leukemia Overview

    The ICD-10-CM C91 group includes malignant lymphoid leukemias affecting the blood and bone marrow, such as chronic and acute lymphocytic leukemias. These diagnoses target the hematopoietic and lymphoid systems and often require documentation of disease subtype, treatment status, and complications. Accurate coding is important for correct clinical records and can affect reimbursement through precise representation of disease complexity.

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    When to Use

    Use a code from this group when a patient has a documented diagnosis of lymphoid leukemia confirmed by clinical evaluation, laboratory testing, or pathology. Select the most specific code reflecting disease subtype, status such as remission or relapse, and any documented complications.

    ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C91.01Acute lymphoblastic leukemia, in remission
    C91.02Acute lymphoblastic leukemia, in relapse
    C91.10Chronic lymphocytic leukemia of B-cell type not having achieved remission
    C91.11Chronic lymphocytic leukemia of B-cell type in remission
    C91.12Chronic lymphocytic leukemia of B-cell type in relapse
    C91.30Prolymphocytic leukemia of B-cell type not having achieved remission
    C91.31Prolymphocytic leukemia of B-cell type, in remission
    C91.32Prolymphocytic leukemia of B-cell type, in relapse
    C91.40Hairy cell leukemia not having achieved remission
    C91.41Hairy cell leukemia, in remission
    C91.42Hairy cell leukemia, in relapse
    C91.50Adult T-cell lymphoma/leukemia (HTLV-1-associated) not having achieved remission
    C91.51Adult T-cell lymphoma/leukemia (HTLV-1-associated), in remission
    C91.52Adult T-cell lymphoma/leukemia (HTLV-1-associated), in relapse
    C91.60Prolymphocytic leukemia of T-cell type not having achieved remission
    C91.61Prolymphocytic leukemia of T-cell type, in remission
    C91.62Prolymphocytic leukemia of T-cell type, in relapse
    C91.90Lymphoid leukemia, unspecified not having achieved remission
    C91.91Lymphoid leukemia, unspecified, in remission

    Showing 1–20 of 27

    DRG Codes

    19 rows

    DRG CodeDescription
    011Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
    012Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
    013Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    834Acute Leukemia with MCC
    835Acute Leukemia with CC
    836Acute Leukemia without CC/MCC
    837Chemotherapy with Acute Leukemia as Secondary Diagnosis or with High Dose Chemotherapy Agent with MCC
    838Chemotherapy with Acute Leukemia as Secondary Diagnosis with CC or High Dose Chemotherapy Agent
    839Chemotherapy with Acute Leukemia as Secondary Diagnosis without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC
    850Acute Leukemia with Other Procedures

    Typical Clinical Scenarios

    • An older adult presents to the emergency department with progressive fatigue, easy bruising, and fever over several days. Laboratory evaluation reveals marked leukocytosis with a predominance of lymphoblasts on peripheral smear and bone marrow biopsy confirming acute lymphoblastic leukemia; immediate admission for induction chemotherapy and infection risk management is required. A diagnosis from this group is assigned to specify the acute lymphoid leukemia subtype and marrow/medullary involvement. Typical codes: C91.00, C91.01
    • A middle-aged patient in long-term hematology follow-up has persistent lymphocytosis diagnosed months ago and now reports night sweats and unintentional weight loss; immunophenotyping and bone marrow biopsy are consistent with chronic lymphocytic leukemia. This is a chronic, ongoing hematologic malignancy managed outpatient with periodic monitoring and treatment planning; a code from this group denotes the chronic lymphoid leukemia status and whether it is in remission or not. Typical codes: C91.10, C91.11
    • A patient with known lymphoid leukemia presents with new severe anemia and thrombocytopenia after cycles of chemotherapy, requiring hospitalization for transfusions and management of febrile neutropenia. The encounter documents treatment complications and persistence of neoplastic disease, so a code from this group is used to identify the underlying lymphoid leukemia as the primary neoplastic diagnosis contributing to current complications. Typical codes: C91.40, C91.41

    Related Codes

    C81-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Hodgkin Lymphoma: Group Overview

    C82-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Follicular Lymphoma: Group Overview

    C83-NON-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Non-Follicular Lymphoma: Group Overview

    C84-MATURE-T-NK-CELL-LYMPHOMAS

    ICD-10-CM Code For Mature T/NK-Cell Lymphomas: Group Overview

    C85-OTHER-SPECIFIED-AND-UNSPECIFIED-NON-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Other Specified And Unspecified Types Of Non Hodgkin Lymphoma: Group Overview

    C86-OTHER-SPECIFIED-T-NK-CELL-LYMPHOMA

    ICD-10-CM Code For Other Specified Types Of T NK Cell Lymphoma: Group Overview

    C88-MALIGNANT-IMMUNOPROLIFERATIVE-DISEASES

    ICD-10-CM Code For Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas: Group Overview

    C90-MULTIPLE-MYELOMA-AND-PLASMA-CELL-NEOPLASMS

    ICD-10-CM Code For Multiple Myeloma And Malignant Plasma Cell Neoplasms: Group Overview

    C92-MYELOID-LEUKEMIA

    ICD-10-CM Code For Myeloid Leukemia: Group Overview

    C93-MONOCYTIC-LEUKEMIA

    ICD-10-CM Code For Monocytic Leukemia: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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