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    v1.0.30
    OpenPayerBilling CodesMalignant neoplasms of lymphoid, hematopoietic and related tissueICD-10-CM c95-leukemia-of-unspecified-cell-type
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    ICD-10-CM Code For Leukemia Of Unspecified Cell Type: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C95 includes leukemias that are not specified by cell lineage, covering unspecified acute and chronic leukemic processes of hematopoietic origin. These ICD-10-CM diagnosis codes are used to document clinical scenarios where the exact cellular origin is unknown or unspecified, capturing disease severity, organ involvement, or clinical complexity relevant to this group. Accurate coding within the ICD-10-CM C95 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C95: Leukemia Of Unspecified Cell Type Overview

    This group represents leukemia diagnoses where the malignant hematopoietic neoplasm is not classified to a specific cell lineage. It targets the blood and bone marrow and related hematopoietic tissues. Accurate coding matters because it affects clinical records and supports correct reimbursement and claims processing. Precise documentation helps ensure appropriate capture of disease burden and treatment complexity.

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    When to Use

    Use a code from this group when a diagnosis documents leukemia without specification of cell lineage or when documentation indicates unspecified leukemia. Codes in this group apply when diagnostic testing or clinical records do not identify a more specific leukemic subtype.

    ICD-10-CM Codes

    9 rows

    ICD-10-CM CodeDescription
    C95.00Acute leukemia of unspecified cell type not having achieved remission
    C95.01Acute leukemia of unspecified cell type, in remission
    C95.02Acute leukemia of unspecified cell type, in relapse
    C95.10Chronic leukemia of unspecified cell type not having achieved remission
    C95.11Chronic leukemia of unspecified cell type, in remission
    C95.12Chronic leukemia of unspecified cell type, in relapse
    C95.90Leukemia, unspecified not having achieved remission
    C95.91Leukemia, unspecified, in remission
    C95.92Leukemia, unspecified, in relapse

    DRG Codes

    16 rows

    DRG CodeDescription
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    834Acute Leukemia with MCC
    835Acute Leukemia with CC
    836Acute Leukemia without CC/MCC
    837Chemotherapy with Acute Leukemia as Secondary Diagnosis or with High Dose Chemotherapy Agent with MCC
    838Chemotherapy with Acute Leukemia as Secondary Diagnosis with CC or High Dose Chemotherapy Agent
    839Chemotherapy with Acute Leukemia as Secondary Diagnosis without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC
    850Acute Leukemia with Other Procedures

    Typical Clinical Scenarios

    • An adult presents to the emergency department with rapidly progressive fever, profound fatigue, diffuse bruising, and new onset petechiae. Peripheral blood smear and flow cytometry demonstrate circulating blasts without clear lineage-specific markers, and cytogenetics are pending; because the leukemia cannot be classified to a specific cell lineage at presentation, an unspecified-cell leukemia code is assigned for acute care and initial treatment planning. Typical codes: C95.00, C95.02
    • A middle-aged patient with a history of leukocytosis treated intermittently in hematology clinic returns for routine follow-up after receiving chemotherapy; bone marrow biopsy shows persistent residual disease but lineage-defining studies are inconclusive, so an unspecified-cell leukemia code is used to document ongoing disease status and guide surveillance. Typical codes: C95.10, C95.12
    • An elderly patient hospitalized for sepsis is found to have anemia, thrombocytopenia, and leukemic blasts on admission labs; the admitting team documents leukemia as a comorbidity without definitive lineage assignment due to the acuity and limited initial testing, prompting use of an unspecified-cell leukemia code to reflect the active malignant hematologic condition impacting inpatient management. Typical codes: C95.90, C95.92

    Related Codes

    C81-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Hodgkin Lymphoma: Group Overview

    C82-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Follicular Lymphoma: Group Overview

    C83-NON-FOLLICULAR-LYMPHOMA

    ICD-10-CM Code For Non-Follicular Lymphoma: Group Overview

    C84-MATURE-T-NK-CELL-LYMPHOMAS

    ICD-10-CM Code For Mature T/NK-Cell Lymphomas: Group Overview

    C85-OTHER-SPECIFIED-AND-UNSPECIFIED-NON-HODGKIN-LYMPHOMA

    ICD-10-CM Code For Other Specified And Unspecified Types Of Non Hodgkin Lymphoma: Group Overview

    C86-OTHER-SPECIFIED-T-NK-CELL-LYMPHOMA

    ICD-10-CM Code For Other Specified Types Of T NK Cell Lymphoma: Group Overview

    C88-MALIGNANT-IMMUNOPROLIFERATIVE-DISEASES

    ICD-10-CM Code For Malignant Immunoproliferative Diseases And Certain Other B-Cell Lymphomas: Group Overview

    C90-MULTIPLE-MYELOMA-AND-PLASMA-CELL-NEOPLASMS

    ICD-10-CM Code For Multiple Myeloma And Malignant Plasma Cell Neoplasms: Group Overview

    C91-LYMPHOID-LEUKEMIA

    ICD-10-CM Code For Lymphoid Leukemia: Group Overview

    C92-MYELOID-LEUKEMIA

    ICD-10-CM Code For Myeloid Leukemia: Group Overview

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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