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    OpenPayerBilling CodesPoisoning by, adverse effects of and underdosing of drugs, medicaments and biological substancesICD-10-CM t46-poisoning-cardiovascular-agents
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    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Agents Primarily Affecting The Cardiovascular System: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group T46 includes diagnoses for poisoning by, adverse effects of, and underdosing of agents that primarily affect the cardiovascular system, covering events related to antihypertensives, antiarrhythmics, vasodilators, and related cardiovascular drugs. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as medication overdoses, drug-induced cardiovascular complications, adverse reactions to prescribed cardiovascular agents, and subtherapeutic dosing causing clinical deterioration. Accurate coding within the ICD-10-CM T46 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM T46: Poisoning By, Adverse Effect Of And Underdosing Of Agents Primarily Affecting The Cardiovascular System Overview

    The ICD-10-CM T46 group represents diagnoses for poisoning, adverse effects, and underdosing of medications that primarily affect the cardiovascular system, such as antihypertensives, antiarrhythmics, and vasodilators. These codes capture events where cardiovascular-targeted agents cause harmful reactions, are taken in error, or are insufficiently dosed leading to clinical consequences. Accurate coding matters for reimbursement because it documents the clinical complexity and justifies the level of care and services provided.

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    When to Use

    Use a code from this group when a patient experiences clinical harm or complications due to overdose, adverse reaction, or insufficient dosing of a cardiovascular-targeted medication. Select the specific T46 code that matches the medication class and the encounter context, and include external cause or encounter codes as required by coding guidelines.

    ICD-10-CM Codes

    198 rows

    ICD-10-CM CodeDescription
    T46.0X1APoisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional), initial encounter
    T46.0X1DPoisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional), subsequent encounter
    T46.0X1SPoisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional), sequela
    T46.0X2APoisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter
    T46.0X2DPoisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, subsequent encounter
    T46.0X2SPoisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, sequela
    T46.0X3APoisoning by cardiac-stimulant glycosides and drugs of similar action, assault, initial encounter
    T46.0X3DPoisoning by cardiac-stimulant glycosides and drugs of similar action, assault, subsequent encounter
    T46.0X3SPoisoning by cardiac-stimulant glycosides and drugs of similar action, assault, sequela
    T46.0X4APoisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined, initial encounter
    T46.0X4DPoisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined, subsequent encounter
    T46.0X4SPoisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined, sequela
    T46.0X5AAdverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter
    T46.0X5DAdverse effect of cardiac-stimulant glycosides and drugs of similar action, subsequent encounter
    T46.0X5SAdverse effect of cardiac-stimulant glycosides and drugs of similar action, sequela
    T46.0X6AUnderdosing of cardiac-stimulant glycosides and drugs of similar action, initial encounter
    T46.0X6DUnderdosing of cardiac-stimulant glycosides and drugs of similar action, subsequent encounter
    T46.0X6SUnderdosing of cardiac-stimulant glycosides and drugs of similar action, sequela
    T46.1X1APoisoning by calcium-channel blockers, accidental (unintentional), initial encounter
    T46.1X1DPoisoning by calcium-channel blockers, accidental (unintentional), subsequent encounter

    Showing 1–20 of 198

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    DRG Codes

    9 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    917Poisoning and Toxic Effects of Drugs with MCC
    918Poisoning and Toxic Effects of Drugs without MCC
    922Other Injury, Poisoning and Toxic Effect Diagnoses with MCC
    923Other Injury, Poisoning and Toxic Effect Diagnoses without MCC
    949Aftercare with CC/MCC
    950Aftercare without CC/MCC
    951Other Factors Influencing Health Status

    Typical Clinical Scenarios

    • An elderly patient on chronic oral beta-blocker therapy develops symptomatic bradycardia and hypotension after accidentally taking an extra dose; they present to the emergency department with dizziness, syncope, and a slow pulse requiring IV fluids and temporary atropine. A poisoning/adverse effect code is assigned to capture the harmful physiological effect of an intended cardiovascular agent taken in excess. Typical codes: T46.0X1A, T46.0X1D
    • A middle-aged patient with congestive heart failure has recurrent episodes of subtherapeutic anticoagulation due to inconsistent dosing and poor medication adherence, resulting in progressive leg swelling and a recent transient ischemic attack; they are seen in clinic for medication reconciliation and dose counseling. An underdosing code is used to document the clinical consequence of insufficient therapeutic effect from an agent primarily affecting the cardiovascular system. Typical codes: T46.3X6A, T46.3X6D
    • A young adult intentionally overdoses on a calcium channel blocker and is brought to the ED unconscious with hypotension, altered mental status, and widened QRS; hospital admission includes gastric decontamination, vasopressor support, and cardiac monitoring for toxicity. An adverse-effect/poisoning code designates the acute toxic exposure to a cardiovascular agent requiring emergent treatment. Typical codes: T46.1X2A, T46.1X2D

    Related Codes

    T36-POISONING-BY-SYSTEMIC-ANTIBIOTICS

    ICD-10-CM Code For Poisoning By, Adverse Effect Of And Underdosing Of Systemic Antibiotics: Group Overview

    T37-OTHER-SYSTEMIC-ANTI-INFECTIVES

    ICD-10-CM Code For Poisoning By Other Systemic Anti Infectives And Antiparasitics: Group Overview

    T38-HORMONE-POISONING-AND-UNDERDOSING

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Hormones And Their Synthetic Substitutes And Antagonists Not Elsewhere Classified: Group Overview

    T39-NONOPIOID-ANALGESIC-POISONING

    ICD-10-CM Code For Poisoning By Nonopioid Analgesics Antipyretics And Antirheumatics: Group Overview

    T40-POISONING-BY-NARCOTICS-AND-HALLUCINOGENS

    ICD-10-CM Code For Poisoning By Narcotics And Psychodysleptics: Group Overview

    T41-ANESTHETICS-AND-THERAPEUTIC-GASES

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Anesthetics And Therapeutic Gases: Group Overview

    T42-ANTIEPILEPTIC-SEDATIVE-HYPNOTIC-ANTIPARKINSONISM-DRUGS

    ICD-10-CM Code For Poisoning By Antiepileptic Sedative Hypnotic And Antiparkinsonism Drugs: Group Overview

    T43-POISONING-AND-ADVERSE-EFFECTS-PSYCHOTROPIC

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Psychotropic Drugs Not Elsewhere Classified: Group Overview

    T44-AUTONOMIC-NERVOUS-SYSTEM-DRUG-EVENTS

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Drugs Primarily Affecting The Autonomic Nervous System: Group Overview

    T45-PRIMARILY-SYSTEMIC-AND-HEMATOLOGICAL-AGENTS

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Primarily Systemic And Hematological Agents Not Elsewhere Classified: Group Overview

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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