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    OpenPayerBilling CodesPoisoning by, adverse effects of and underdosing of drugs, medicaments and biological substancesICD-10-CM t43-poisoning-and-adverse-effects-psychotropic
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    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Psychotropic Drugs Not Elsewhere Classified: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group T43 includes poisoning by, adverse effects of, and underdosing of psychotropic drugs not classified elsewhere, covering manifestations from toxic reactions to insufficient therapeutic dosing of psychiatric agents. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as drug overdose, medication-related adverse reactions, and subtherapeutic dosing that affect mental status, behavior, or neurologic function. Accurate coding within the ICD-10-CM T43 group supports proper claim adjudication and complete clinical documentation and appropriate reimbursement.

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    ICD-10-CM T43: Poisoning By, Adverse Effect Of And Underdosing Of Psychotropic Drugs, Not Elsewhere Classified Overview

    This group of diagnoses represents poisoning, adverse effects, and underdosing related to psychotropic medications that do not fall into more specific categories. It targets the effects of psychiatric and neurologic agents on the nervous system and mental status. Accurate coding ensures the clinical picture of medication-related harm or inadequate therapy is captured and supports appropriate reimbursement and care continuity.

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    When to Use

    Use a code from this group when a patient presents with clinical effects attributable to poisoning by or adverse reactions to psychotropic medications that lack a more specific code. Also apply these codes when documented underdosing of psychotropic drugs results in clinically relevant insufficient therapeutic effect.

    ICD-10-CM Codes

    354 rows

    ICD-10-CM CodeDescription
    T43.011APoisoning by tricyclic antidepressants, accidental (unintentional), initial encounter
    T43.011DPoisoning by tricyclic antidepressants, accidental (unintentional), subsequent encounter
    T43.011SPoisoning by tricyclic antidepressants, accidental (unintentional), sequela
    T43.012APoisoning by tricyclic antidepressants, intentional self-harm, initial encounter
    T43.012DPoisoning by tricyclic antidepressants, intentional self-harm, subsequent encounter
    T43.012SPoisoning by tricyclic antidepressants, intentional self-harm, sequela
    T43.013APoisoning by tricyclic antidepressants, assault, initial encounter
    T43.013DPoisoning by tricyclic antidepressants, assault, subsequent encounter
    T43.013SPoisoning by tricyclic antidepressants, assault, sequela
    T43.014APoisoning by tricyclic antidepressants, undetermined, initial encounter
    T43.014DPoisoning by tricyclic antidepressants, undetermined, subsequent encounter
    T43.014SPoisoning by tricyclic antidepressants, undetermined, sequela
    T43.015AAdverse effect of tricyclic antidepressants, initial encounter
    T43.015DAdverse effect of tricyclic antidepressants, subsequent encounter
    T43.015SAdverse effect of tricyclic antidepressants, sequela
    T43.016AUnderdosing of tricyclic antidepressants, initial encounter
    T43.016DUnderdosing of tricyclic antidepressants, subsequent encounter
    T43.016SUnderdosing of tricyclic antidepressants, sequela
    T43.021APoisoning by tetracyclic antidepressants, accidental (unintentional), initial encounter
    T43.021DPoisoning by tetracyclic antidepressants, accidental (unintentional), subsequent encounter

    Showing 1–20 of 354

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    DRG Codes

    9 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    917Poisoning and Toxic Effects of Drugs with MCC
    918Poisoning and Toxic Effects of Drugs without MCC
    922Other Injury, Poisoning and Toxic Effect Diagnoses with MCC
    923Other Injury, Poisoning and Toxic Effect Diagnoses without MCC
    949Aftercare with CC/MCC
    950Aftercare without CC/MCC
    951Other Factors Influencing Health Status

    Typical Clinical Scenarios

    • An adult patient presents to the emergency department after intentionally ingesting an excessive amount of his prescribed tricyclic antidepressant in a suicide attempt, with altered mental status, hypotension, and arrhythmia on ECG. Emergency stabilization and toxicology evaluation confirm acute poisoning by a psychotropic antidepressant, so an initial encounter poisoning code from the group is assigned to capture the overdose and need for emergency care. Typical codes: T43.011A, T43.012A
    • An elderly outpatient on chronic antipsychotic therapy develops progressive extrapyramidal symptoms and is seen in clinic for medication management after missed doses and subtherapeutic levels are documented; the clinician documents underdosing of the psychotropic agent leading to symptom worsening. A code indicating underdosing in this drug class is used to reflect therapeutic failure due to insufficient medication dosing during the outpatient visit. Typical codes: T43.1X5A, T43.1X6A
    • A hospitalized patient receiving a mood-stabilizing psychotropic medication develops a serious adverse drug reaction (e.g., severe neutropenia) attributed to the medication during the admission, requiring drug discontinuation and additional treatment. A code for adverse effect of the psychotropic medication is assigned to capture the iatrogenic complication as part of the inpatient stay. Typical codes: T43.021A, T43.022A

    Related Codes

    T36-POISONING-BY-SYSTEMIC-ANTIBIOTICS

    ICD-10-CM Code For Poisoning By, Adverse Effect Of And Underdosing Of Systemic Antibiotics: Group Overview

    T37-OTHER-SYSTEMIC-ANTI-INFECTIVES

    ICD-10-CM Code For Poisoning By Other Systemic Anti Infectives And Antiparasitics: Group Overview

    T38-HORMONE-POISONING-AND-UNDERDOSING

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Hormones And Their Synthetic Substitutes And Antagonists Not Elsewhere Classified: Group Overview

    T39-NONOPIOID-ANALGESIC-POISONING

    ICD-10-CM Code For Poisoning By Nonopioid Analgesics Antipyretics And Antirheumatics: Group Overview

    T40-POISONING-BY-NARCOTICS-AND-HALLUCINOGENS

    ICD-10-CM Code For Poisoning By Narcotics And Psychodysleptics: Group Overview

    T41-ANESTHETICS-AND-THERAPEUTIC-GASES

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Anesthetics And Therapeutic Gases: Group Overview

    T42-ANTIEPILEPTIC-SEDATIVE-HYPNOTIC-ANTIPARKINSONISM-DRUGS

    ICD-10-CM Code For Poisoning By Antiepileptic Sedative Hypnotic And Antiparkinsonism Drugs: Group Overview

    T44-AUTONOMIC-NERVOUS-SYSTEM-DRUG-EVENTS

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Drugs Primarily Affecting The Autonomic Nervous System: Group Overview

    T45-PRIMARILY-SYSTEMIC-AND-HEMATOLOGICAL-AGENTS

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Primarily Systemic And Hematological Agents Not Elsewhere Classified: Group Overview

    T46-POISONING-CARDIOVASCULAR-AGENTS

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Agents Primarily Affecting The Cardiovascular System: Group Overview

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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