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    OpenPayerBilling CodesPoisoning by, adverse effects of and underdosing of drugs, medicaments and biological substancesICD-10-CM t44-autonomic-nervous-system-drug-events
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    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Drugs Primarily Affecting The Autonomic Nervous System: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group T44 includes poisoning by, adverse effects of, and underdosing of drugs that primarily affect the autonomic nervous system, such as sympathomimetics, parasympathomimetics, and autonomic-blocking agents. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving toxic exposure, medication side effects, or insufficient dosing that alter autonomic function and may impact multiple organ systems. Accurate coding within the ICD-10-CM T44 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM T44: Poisoning By, Adverse Effect Of And Underdosing Of Drugs Primarily Affecting The Autonomic Nervous System Overview

    This group represents diagnoses related to poisoning, adverse effects, and underdosing of medications that primarily affect the autonomic nervous system, including agents that alter sympathetic or parasympathetic function. These conditions can affect cardiovascular, gastrointestinal, genitourinary, and respiratory control mediated by autonomic pathways. Accurate coding matters because it supports appropriate claim adjudication and reflects the clinical complexity and resource use associated with autonomic drug events.

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    When to Use

    Use a code from this group when a patient presents with signs or complications due to toxic exposure to, adverse reactions from, or insufficient dosing of drugs affecting autonomic control. Assign codes that reflect the intent and circumstance (e.g., poisoning, adverse effect, or underdosing) and document any associated systemic effects or sequelae.

    ICD-10-CM Codes

    198 rows

    ICD-10-CM CodeDescription
    T44.0X1APoisoning by anticholinesterase agents, accidental (unintentional), initial encounter
    T44.0X1DPoisoning by anticholinesterase agents, accidental (unintentional), subsequent encounter
    T44.0X1SPoisoning by anticholinesterase agents, accidental (unintentional), sequela
    T44.0X2APoisoning by anticholinesterase agents, intentional self-harm, initial encounter
    T44.0X2DPoisoning by anticholinesterase agents, intentional self-harm, subsequent encounter
    T44.0X2SPoisoning by anticholinesterase agents, intentional self-harm, sequela
    T44.0X3APoisoning by anticholinesterase agents, assault, initial encounter
    T44.0X3DPoisoning by anticholinesterase agents, assault, subsequent encounter
    T44.0X3SPoisoning by anticholinesterase agents, assault, sequela
    T44.0X4APoisoning by anticholinesterase agents, undetermined, initial encounter
    T44.0X4DPoisoning by anticholinesterase agents, undetermined, subsequent encounter
    T44.0X4SPoisoning by anticholinesterase agents, undetermined, sequela
    T44.0X5AAdverse effect of anticholinesterase agents, initial encounter
    T44.0X5DAdverse effect of anticholinesterase agents, subsequent encounter
    T44.0X5SAdverse effect of anticholinesterase agents, sequela
    T44.0X6AUnderdosing of anticholinesterase agents, initial encounter
    T44.0X6DUnderdosing of anticholinesterase agents, subsequent encounter
    T44.0X6SUnderdosing of anticholinesterase agents, sequela
    T44.1X1APoisoning by other parasympathomimetics [cholinergics], accidental (unintentional), initial encounter
    T44.1X1DPoisoning by other parasympathomimetics [cholinergics], accidental (unintentional), subsequent encounter

    Showing 1–20 of 198

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    DRG Codes

    9 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    917Poisoning and Toxic Effects of Drugs with MCC
    918Poisoning and Toxic Effects of Drugs without MCC
    922Other Injury, Poisoning and Toxic Effect Diagnoses with MCC
    923Other Injury, Poisoning and Toxic Effect Diagnoses without MCC
    949Aftercare with CC/MCC
    950Aftercare without CC/MCC
    951Other Factors Influencing Health Status

    Typical Clinical Scenarios

    • An adult patient presents to the emergency department with acute bradycardia, hypotension, excessive salivation, and miosis after accidentally ingesting a large quantity of a prescribed beta-blocker that also has significant anticholinergic activity; the presentation is consistent with an acute overdose requiring stabilization and possible antidote therapy. A poisoning code from this group is assigned to indicate the toxic effect of the autonomic nervous system–acting drug and the encounter for initial emergency care. Typical codes: T44.3X1A, T44.3X1D
    • An older patient with Parkinson disease is seen in clinic for progressive orthostatic hypotension and marked constipation after chronic high-dose therapy with a peripheral autonomic agent; symptoms are attributed to adverse effects of the medication and dosing is being adjusted. A code from this group is used to document an adverse effect of a drug primarily affecting the autonomic nervous system during an outpatient follow-up visit. Typical codes: T44.2X5A, T44.2X5D
    • A hospitalized postoperative patient develops inadequate control of heart rate and blood pressure after a nursing documentation review reveals the patient missed multiple scheduled doses of their home autonomic-acting antihypertensive medication, leading to withdrawal-related tachycardia and hypertension requiring monitoring. A code from this group is assigned to capture underdosing (omission) of the autonomic drug as a contributing factor to the patient’s clinical deterioration. Typical codes: T44.1X6A, T44.1X6D

    Related Codes

    T36-POISONING-BY-SYSTEMIC-ANTIBIOTICS

    ICD-10-CM Code For Poisoning By, Adverse Effect Of And Underdosing Of Systemic Antibiotics: Group Overview

    T37-OTHER-SYSTEMIC-ANTI-INFECTIVES

    ICD-10-CM Code For Poisoning By Other Systemic Anti Infectives And Antiparasitics: Group Overview

    T38-HORMONE-POISONING-AND-UNDERDOSING

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Hormones And Their Synthetic Substitutes And Antagonists Not Elsewhere Classified: Group Overview

    T39-NONOPIOID-ANALGESIC-POISONING

    ICD-10-CM Code For Poisoning By Nonopioid Analgesics Antipyretics And Antirheumatics: Group Overview

    T40-POISONING-BY-NARCOTICS-AND-HALLUCINOGENS

    ICD-10-CM Code For Poisoning By Narcotics And Psychodysleptics: Group Overview

    T41-ANESTHETICS-AND-THERAPEUTIC-GASES

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Anesthetics And Therapeutic Gases: Group Overview

    T42-ANTIEPILEPTIC-SEDATIVE-HYPNOTIC-ANTIPARKINSONISM-DRUGS

    ICD-10-CM Code For Poisoning By Antiepileptic Sedative Hypnotic And Antiparkinsonism Drugs: Group Overview

    T43-POISONING-AND-ADVERSE-EFFECTS-PSYCHOTROPIC

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Psychotropic Drugs Not Elsewhere Classified: Group Overview

    T45-PRIMARILY-SYSTEMIC-AND-HEMATOLOGICAL-AGENTS

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Primarily Systemic And Hematological Agents Not Elsewhere Classified: Group Overview

    T46-POISONING-CARDIOVASCULAR-AGENTS

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Agents Primarily Affecting The Cardiovascular System: Group Overview

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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