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    OpenPayerBilling CodesPoisoning by, adverse effects of and underdosing of drugs, medicaments and biological substancesICD-10-CM t45-primarily-systemic-and-hematological-agents
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    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Primarily Systemic And Hematological Agents Not Elsewhere Classified: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group T45 includes poisoning by, adverse effects of, and underdosing of primarily systemic and hematological agents not classified elsewhere, covering medication toxicity, adverse reactions, and insufficient dosing of systemic hematologic drugs. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as accidental or intentional overdoses, documented adverse effects from therapeutic use, and clinically significant underdosing that affects patient management or outcomes. Accurate coding within the ICD-10-CM T45 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM T45: Poisoning By, Adverse Effect Of And Underdosing Of Primarily Systemic And Hematological Agents, Not Elsewhere Classified Overview

    This group includes codes for poisoning, adverse effects, and underdosing of primarily systemic and hematologic agents that are not classified elsewhere. These diagnoses target systemic medications affecting blood and related systemic therapies. Accurate coding ensures clinical events are captured and supports appropriate reimbursement and claims adjudication.

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    When to Use

    Use a code from this group when a clinical record documents poisoning, an adverse effect, or underdosing involving primarily systemic or hematological agents that do not have a more specific code elsewhere. Select the appropriate sixth or seventh character as required to indicate the encounter type, intent, or sequela when applicable.

    ICD-10-CM Codes

    270 rows

    ICD-10-CM CodeDescription
    T45.0X1APoisoning by antiallergic and antiemetic drugs, accidental (unintentional), initial encounter
    T45.0X1DPoisoning by antiallergic and antiemetic drugs, accidental (unintentional), subsequent encounter
    T45.0X1SPoisoning by antiallergic and antiemetic drugs, accidental (unintentional), sequela
    T45.0X2APoisoning by antiallergic and antiemetic drugs, intentional self-harm, initial encounter
    T45.0X2DPoisoning by antiallergic and antiemetic drugs, intentional self-harm, subsequent encounter
    T45.0X2SPoisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela
    T45.0X3APoisoning by antiallergic and antiemetic drugs, assault, initial encounter
    T45.0X3DPoisoning by antiallergic and antiemetic drugs, assault, subsequent encounter
    T45.0X3SPoisoning by antiallergic and antiemetic drugs, assault, sequela
    T45.0X4APoisoning by antiallergic and antiemetic drugs, undetermined, initial encounter
    T45.0X4DPoisoning by antiallergic and antiemetic drugs, undetermined, subsequent encounter
    T45.0X4SPoisoning by antiallergic and antiemetic drugs, undetermined, sequela
    T45.0X5AAdverse effect of antiallergic and antiemetic drugs, initial encounter
    T45.0X5DAdverse effect of antiallergic and antiemetic drugs, subsequent encounter
    T45.0X5SAdverse effect of antiallergic and antiemetic drugs, sequela
    T45.0X6AUnderdosing of antiallergic and antiemetic drugs, initial encounter
    T45.0X6DUnderdosing of antiallergic and antiemetic drugs, subsequent encounter
    T45.0X6SUnderdosing of antiallergic and antiemetic drugs, sequela
    T45.1X1APoisoning by antineoplastic and immunosuppressive drugs, accidental (unintentional), initial encounter
    T45.1X1DPoisoning by antineoplastic and immunosuppressive drugs, accidental (unintentional), subsequent encounter

    Showing 1–20 of 270

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    DRG Codes

    9 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    917Poisoning and Toxic Effects of Drugs with MCC
    918Poisoning and Toxic Effects of Drugs without MCC
    922Other Injury, Poisoning and Toxic Effect Diagnoses with MCC
    923Other Injury, Poisoning and Toxic Effect Diagnoses without MCC
    949Aftercare with CC/MCC
    950Aftercare without CC/MCC
    951Other Factors Influencing Health Status

    Typical Clinical Scenarios

    • An elderly patient on long-term warfarin therapy presents to the emergency department with acute onset of large-volume melena and hypotension after a recent dose increase; laboratory tests show an elevated INR consistent with over-anticoagulation. This is an acute poisoning/adverse effect from an anticoagulant agent leading to significant bleeding that requires urgent evaluation and reversal measures; a code from this group is assigned to capture the adverse effect of the systemic anticoagulant. Typical codes: T45.515A, T45.515D
    • An outpatient with end-stage renal disease reports progressive weakness and pallor over weeks after multiple missed doses of prescribed erythropoiesis-stimulating agents; the clinician documents underdosing of the hematological agent resulting in symptomatic worsening of anemia and a medication management problem. This represents an ongoing underdosing event of a systemic hematological drug causing clinical deterioration and is coded to reflect underdosing rather than toxicity. Typical codes: T45.6X6A, T45.6X6D
    • A middle-aged patient receiving chemotherapy develops neutropenic fever and severe bone marrow suppression attributed to an adverse reaction to a systemic antineoplastic agent; hospital admission is required for infection management and supportive care. Because the presentation is a complication from a systemic cytotoxic drug causing hematologic toxicity, an adverse effect code from this group is used to document the drug-related cause of the complication. Typical codes: T45.1X5A, T45.1X5D

    Related Codes

    T36-POISONING-BY-SYSTEMIC-ANTIBIOTICS

    ICD-10-CM Code For Poisoning By, Adverse Effect Of And Underdosing Of Systemic Antibiotics: Group Overview

    T37-OTHER-SYSTEMIC-ANTI-INFECTIVES

    ICD-10-CM Code For Poisoning By Other Systemic Anti Infectives And Antiparasitics: Group Overview

    T38-HORMONE-POISONING-AND-UNDERDOSING

    ICD-10-CM Code For Poisoning By Adverse Effect And Underdosing Of Hormones And Their Synthetic Substitutes And Antagonists Not Elsewhere Classified: Group Overview

    T39-NONOPIOID-ANALGESIC-POISONING

    ICD-10-CM Code For Poisoning By Nonopioid Analgesics Antipyretics And Antirheumatics: Group Overview

    T40-POISONING-BY-NARCOTICS-AND-HALLUCINOGENS

    ICD-10-CM Code For Poisoning By Narcotics And Psychodysleptics: Group Overview

    T41-ANESTHETICS-AND-THERAPEUTIC-GASES

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Anesthetics And Therapeutic Gases: Group Overview

    T42-ANTIEPILEPTIC-SEDATIVE-HYPNOTIC-ANTIPARKINSONISM-DRUGS

    ICD-10-CM Code For Poisoning By Antiepileptic Sedative Hypnotic And Antiparkinsonism Drugs: Group Overview

    T43-POISONING-AND-ADVERSE-EFFECTS-PSYCHOTROPIC

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Psychotropic Drugs Not Elsewhere Classified: Group Overview

    T44-AUTONOMIC-NERVOUS-SYSTEM-DRUG-EVENTS

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Drugs Primarily Affecting The Autonomic Nervous System: Group Overview

    T46-POISONING-CARDIOVASCULAR-AGENTS

    ICD-10-CM Code For Poisoning By Adverse Effect Of And Underdosing Of Agents Primarily Affecting The Cardiovascular System: Group Overview

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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